west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "孙祺" 3 results
  • Analysis of transcriptomic differences of duodenal neuroendocrine tumor accompanied by liver and lymph node metastases

    ObjectiveTo explore the key genes and potential molecular mechanisms of liver and lymph node metastases relevant to duodenal neuroendocrine tumors (DNET). MethodsThe tissues of paracancerous duodenal epithelial, primary lesion, liver metastasis lesion, and lymph node metastasis lesion of a rare DNET accompanied by liver and lymph node metastases were sequenced and analyzed. The differentially expressed genes (DEGs) were screened for different tissues and the functional enrichment analysis was performed. ResultsThe tissues of paracancerous duodenal epithelial was used as the control, a total of 2 053 DEGs expressed only in the liver metastases lesion tissues and 742 DEGs expressed only in the lymph node metastases lesion tissues were screened out, and the top 5 genes expressed in the liver metastases lesion tissues were ORM1, C4BPA, AHSG, C9, and LBP, which in the lymph node metastases lesion tissues were ABHD12B, AC100850.1, HOXC9, AC083967.1, and HOXC8. Kyoto Encyclopedia of Genes and Genomes enrichment analysis found that the DEGs were mainly enriched in the phosphatidylinosiol 3 kinase / protein kinase B pathway, mitogen-activated protein kinase pathway, human papillomavirus infection, etc. ConclusionMultiple DEGs and pathways in metastatic lesions are found in this patient with DNET accompanied by liver metastasis and lymph node metastasis, which provides a new direction for treatment and prophylaxis of DNET.

    Release date: Export PDF Favorites Scan
  • 局部进展期中低位直肠癌新辅助治疗对淋巴结检出数目的影响及预后分析

    目的分析接受新辅助治疗的局部进展期中低位直肠癌患者在根治性切除术中可能影响淋巴结检出数目的因素,并分析淋巴结检出数目对预后的影响。方法回顾性分析2016年3月至2021年12月期间西安交通大学第一附属医院收治且接受新辅助治疗联合根治性手术的局部进展期中低位直肠癌患者的临床病理资料,采用线性回归模型筛选影响淋巴结检出数目的因素,Kaplan-Meier法绘制生存曲线。结果共收集到81例局部进展期中低位直肠癌根治性切除术患者,淋巴结检出数目(12.11±5.54)枚/例;检出淋巴结平均数目 <12枚者42例、≥12枚者39例。多因素线性回归模型分析结果显示,男性患者和联合新辅助放疗可降低检出淋巴结数目的概率(分别为:t=–3.17,P=0.002;t=–2.44,P=0.017)。以检出淋巴结平均数目12枚为截点分析 <12枚和 ≥12枚患者的Kaplan-Meier法绘制的生存曲线,经log-rank检验发现,检出淋巴结平均数目 <12枚和 ≥12枚患者的总生存和无病生存曲线比较差异均无统计学意义(分别为:χ2=0.107,P=0.743;χ2=0.027,P=0.870)。对64例临床区域淋巴结阳性患者将淋巴结检出数目平均6~13枚分别以 <6枚/≥6枚、……和 <13枚/≥13枚作为分组截点进行分层分析的结果显示,以平均7枚和8枚淋巴结检出数目作为分组截点的2组患者的累积总生存情况比较差异有统计学意义(χ2=3.977,P=0.046;χ2=3.977,P=0.046),即检出淋巴结平均数目至少7枚或8枚者的总生存情况更好。结论本研究的数据分析结果提示,男性患者和联合了新辅助放疗的患者对术后获检淋巴结数目会有一定的影响;从总体患者的生存分析看,未发现检出淋巴结数目与总生存和复发有关,但在临床区域淋巴结阳性的患者中发现,至少检出7枚或8枚淋巴结可以改善患者的预后。

    Release date: Export PDF Favorites Scan
  • Analysis of surgical treatment of traumatic duodenal injury

    Objective To investigate the surgical treatment and outcomes for duodenal injury in blunt abdominal trauma. Methods Clinical data of patients with traumatic duodenal injury who underwent surgical treatment in the First Affiliated Hospital of Xi’an Jiaotong University between December 2014 and August 2023 were retrospectively collected. The injury causes, diagnostic methods, surgical treatment methods, curative effect, and complications of patients were analyzed. Results A total of 8 patients were included. Among them, there were 7 males and 1 female. The age ranged from 17 to 66 years old, with an average of (44.4±19.3) years old. There were 5 cases of traffic accident injury, 2 cases of crush injury, and 1 case of falling injury. There was 1 case of duodenal bulb injury, 3 cases of descending part injury, 3 cases of horizontal part injury and 1 case of both descending and horizontal injuries. According to the scale of American Association for the Surgery of Trauma for duodenal trauma, there were 5 cases of grade Ⅱ injury, 2 cases of grade Ⅲ injury, and 1 case of grade Ⅳ injury. All patients underwent CT scan, of which 2 cases were directly diagnosed with duodenal injuries by CT, and the remaining cases diagnosed by intraoperative exploration. All patients underwent surgical treatment, including 4 cases of pancreaticoduodenectomy, 2 cases of duodenal repair and gastrojejunostomy, 1 case of duodenal repair plus jejunostomy, and 1 case of superior mesenteric vein repair, pancreatic necrotic tissue removal, and abdominal catheterization for smooth drainage. One patient developed duodenal fistula on the ninth day after surgery and received secondary surgery, 1 died of multiple organ failure during the resuscitation phase after damage control surgery, 3 developed intra-abdominal infection and cured by anti-infective treatment. Conclusions Early clinical manifestations of traumatic duodenal injuries are atypical, and imaging findings might not be clear. For trauma patients suspected of having duodenal injury, rigorous vital sign monitoring is necessary. Once vital signs stabilize, exploratory surgery should be actively considered to identify the location of the injury and perform appropriate surgical procedures. Adequate postoperative enteric decompression and drainage should be ensured.

    Release date: Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content