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find Author "安宁" 7 results
  • 丙氨酸转氨酶的研究现状与进展

    丙氨酸转氨酶(ALT)作为一种临床重要的生化指标,在人体具有两种同工酶,即ALT1和ALT2。ALT1主要表达与肝脏、肌肉、消化道、脂肪和心脏,而ALT2主要则表达于肝脏、肌肉、脑和脂肪组织。通常认为血清中ALT是通过肝脏细胞不断的自我更新过程中或通过坏死的肝细胞释放出来,后来发现ALT还可以是由肝细胞膜出芽破裂的方式释放。在大多急慢性坏死性肝脏疾病中,血清ALT是升高的。但在一些非肝脏疾病,如肌肉或者肠道损伤的情况下也有可能引起血清ALT升高。同时ALT作为一种重要的代谢酶,在糖、脂、氨基酸的代谢中也起着重要的作用。ALT在机体无氧运动的条件下参与丙氨酸葡萄糖循环而维持血糖的稳态。

    Release date:2016-09-08 09:45 Export PDF Favorites Scan
  • Treatment of Different Types of Biliary Duct Injury in Laparoscopic Cholecystectomy

    目的 总结腹腔镜胆囊切除术(LC)胆管损伤的特点和处理经验,以提高治愈率。方法 回顾性分析81例LC术中胆管损伤的临床资料。结果 49例肝总管刺破伤,及时于腹腔镜下缝合8例,中转开腹修补33例,术后发现再开腹修补8例; 12例胆总管横断伤,术中发现10例中转开腹行胆总管端端吻合术、T管支撑引流,术后发现2例先行腹腔引流,3个月后再行胆肠吻合; 8例胆总管部分夹闭者,行剖腹取钛夹、T管支撑胆管引流半年; 10例肝总管及胆总管缺损和2例肝总管缺损伴左、右肝管部分夹闭者,均先行引流,3个月后再行肝门胆管空肠吻合术。全组病例经上述治疗后均痊愈出院。结论 不同类型的胆管损伤应采用不同的方式在不同的时间进行相应处理可获良好疗效。

    Release date:2016-09-08 11:07 Export PDF Favorites Scan
  • Clinical Efficacy of Laparoscopic Minimally-invasive Surgery for Gallbladder Stone

    ObjectiveTo investigate and compare the advantages and disadvantages of laparoscopic cholecystolithotomy and laparoscopic cholecystectomy for patients with gallbladder stone. MethodsThe eligible patients with gallbladder stones hospitalized in our department between January 2007 and December 2011 were included, and all of them received either laparoscopic cholecystolithotomy (observation group) or laparoscopic cholecystectomy (control group) minimally-invasive surgery. The operation time, bleeding volume, enterokinesia recovery time, hospital stay, post-operative complication and follow-up results were compared between the two groups. ResultsA total of 148 patients were included, with 68 patients in the observation group and 80 patients in the control group. In this cohort, the success rate of surgery for the observation group and the control group was 100.0% (68/68) and 98.8% (79/80), respectively; and the success rate of complete stone removal was 100% for both two groups. B-ultrasound examination after 2 weeks of treatment showed that gallbladder wall was normal and gallbladder contraction rate was more than 30% for all patients with laparoscopic cholecystolithotomy. The operation time was (49.6±5.2) minutes for the observation group and (50.5±6.2) minutes for the control group, and bleeding volume was (9.5±1.4) mL for the observation group and (50.2±8.1) mL for the control group; the difference in bleeding volume was significant between the two groups (P<0.05). The difference in enterokinesia recovery time[(33.9±2.2) and (34.4±2.6) minutes] or hospital stay[(3.4±1.0) and (3.6±1.2) days] between the observation group and the control group was not significant (both P >0.05). The post-operative complications of bleeding, bile leakage and wound infection were not observed in both two groups, and all patients were followed up for 6 to 12 months with no stone recurrence; and only 2.7% of patients (1/37) had stone recurrence after 3-year follow-up. ConclusionBoth laparoscopic cholecystolithotomy and laparoscopic cholecystectomy procedures are safe and efficient. However, laparoscopic cholecystolithotomy not only reserves gallbladder but also has superiority of less bleeding volume.

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  • VERTICAL TRAPEZIUS MYOCUTANEOUS FLAP FOR REPAIRING SOFT TISSUE DEFECT AFTER HEAD AND NECK TUMOR RESECTION

    Objective To introduce the experience of the cl inical appl ication of vertical trapezius myocutaneous flap in repairing soft tissue defects after head and neck tumor resection. Methods Between June 2008 and February 2010, 12 cases of soft tissue defect caused by head and neck tumor resection were repaired with vertical trapezius myocutaneous flap.There were 9 males and 3 females with an age range from 32 to 76 years (median, 54 years). Twelve cases including 2 cases of basal cell carcinoma of orbital skin, 2 cases of squamous cell carcinoma of the parotid gland, 2 cases of submandibular gland mal ignant mixed tumor, 2 cases of metastatic lymph nodes of nasopharyngea carcinoma after radiotherapy, 1 case of squamous cell carcinoma of tongue, and 3 cases of squamous cell carcinoma of occipital skin, and all were classified as TNM stages T3 or T4. The area of soft tissue defect ranged from 13 cm × 6 cm to 25 cm × 13 cm. The vertical trapezius myocutaneous flap ranged from 14 cm × 7 cm to 26 cm × 14 cm and was transfered to repair defect tissue in the homolateral wounds after tumor resection and neck dissection homochronously. The donor sites were sutured directly. Results All incisions healed primarily without infection. Eleven flaps survived except 1 flap with edge necrosis, which was cured after dressing change. Subcutaneous hematocele and effusion occurred in 2 cases on the back after tube was removed at 7 days postoperatively, and they were cured by sucted and pressured dressing. Eleven patients were followed up 1-3 years (mean, 2 years). Nine cases had no tumor recurrence and the flaps had statisfactory appearance; the abduction function of shoulder joint were normal. One case of orbit basal cell carcinoma occurred 3 months after operation and 1 case of nasopharyngeal carcinoma died of brain metastasis 12 months after operation. Conclusion It is an easy and simple therapy to repair head and neck soft tissue defect using the vertical trapezius myocutaneous flap, which can meet the needs of repairing tissue defect of head and neck.

    Release date:2016-08-31 05:44 Export PDF Favorites Scan
  • Quality Assessement on the Studies of Traditional Chinese Medicine for Coronary Heart Disease Angina

    Objective To assess the quality of randomised controlled trials on traditional Chinese medicine (TCM) for coronary heart disease (CHD) angina published from 1977 to 2002. Method We did electronic search in Medline, Embase and hand searched 83 journals of traditional Chinese medicine (the earliest published in 1977 and the latest in June 2002). We assessed the quality of obstained studies. Results Four hundred and forty articles met the criteria,of which 33 (7.5%) described randomization. None of them mentioned allocation concealment; 94.77% (417 studies) mentioned diagnosis criteria; only one mentioned the calculation basement of sample size; 84.09% (370 studies) mentioned comparability of baseline. Fifty three studies (12.05%) noted double-blind; 28 studies used single blind. Twenty-five studies used double-blind. Drop-outs were described in 7 cases without intention-to-treat (ITT); 159 studies applied statistical methods properly, while 4 did not. Ten studies never mentioned statistical methods; 73.18% (322 studies) used forms to express their results. Conclusions Till now, the quantity and quality of RCTs of traditional Chinese medicine for coronary heart disease angina were inadequate. Some well designed scientific methods were not adequately applied.

    Release date:2016-09-07 02:27 Export PDF Favorites Scan
  • Silk Ligation Neck of Cystic Duct and Cystic Artery in Laparoscopic Cholecystectomy

    目的探讨腹腔镜胆囊切除术(LC)术中用丝线结扎胆囊颈管和胆囊动脉的方法及临床效果。方法在13 159例LC 手术中,97%(12 745/13 159)不使用钛夹而采用普通丝线结扎胆囊颈管和胆囊动脉。结果占总病例73.0%的单纯性结石性胆囊炎、胆囊息肉和胆囊炎病例,平均手术时间21 min。急性胆囊炎、胆囊结石的病例,平均手术时间52 min。全部病例无一例因此方法处理胆囊颈管和胆囊动脉而发生术后胆漏、出血等并发症,恢复较快,术后3~5 d出院,患者体内无金属异物存在,无相应不良影响。结论丝线结扎胆囊颈管和胆囊动脉,操作简单,结扎可靠,缩短手术时间,减少术中损伤肝外胆管和邻近器官,降低术中风险,避免金属异物留置体内引起的不良影响,拓宽手术指征,更适用胆囊急性炎症期、胆囊颈管增粗的病例,其治愈率较高,并发症少。

    Release date:2016-09-08 11:53 Export PDF Favorites Scan
  • A comparative study on the value of stereo-electroencephalography and subdural cortical electrodes monitoring in preoperative evaluation of epileptogenic zone: stereo-electroencephalography with less complication of hemorrhage and infection

    ObjectiveThe purpose of this study was to compare the value of SEEG and subdural cortical electrodes monitoring in preoperative evaluation of epileptogenic zone. MethodsFeatures of patients using SEEG (48 cases) and subdural cortical electrodes monitoring (52 cases) to evaluate the epileptogenic zone were collected from June 2011 to June 2015. And the evaluation results, surgical effects and complications were compared. ResultsThere was no significant difference between SEEG and subdural cortical electrodes monitoring in identifying the epileptogenic zone or taking epileptic surgery, but SEEG could monitor multifocal and bilateral epileptogenic zone. And there was no significant difference in postoperative seizure control and intelligence improvement (P > 0.05). The total complication rate of SEEG was lower than subdural cortical electrodes monitoring, especially in hemorrhage and infection (P < 0.05). ConclusionsThere was no difference among SEEG and subdural cortical electrodes monitoring in surgical results, but SEEG with less hemorrhagic and infectious risks. SEEG is a safe and effective intracranial monitoring method, which can be widely used.

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