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find Keyword "宫颈" 88 results
  • Diagnostic Value of TERC Gene on High-Grade Squamous Intraepithelial Lesion of the Cervix: A Meta-Analysis

    Objective To systematically evaluate the diagnostic value of TERC gene on high-grade squamous intraepithelial lesion (HGSIL) of the cervix. Methods Such databases as PubMed, EMbase, and The Cochrane Library were searched by March 31, 2012. According to the inclusion and exclusion criteria, the literature was screened and the data were extracted. The quality was evaluated in accordance with the quality assessment tool for diagnostic accuracy studies (QUADAS) and the meta-analysis was conducted by using Meta-Disc 1.4 software. Result A total of 12 studies involving 7 894 cases were included. The results of meta-analysis showed that the sensitivity, specificity and diagnostic odds ratios of TERC gene on HGSIL of cervix were 0.81 (95%CI 0.80 to 0.82), 0.83 (95%CI 0.82 to 0.84), 17.37 (95%CI 8.77 to 34.41), respectively. Conclusions The diagnostic value of TERC gene were medium in diagnosing HGSIL of the cervix alone, and it can be used as an optional method in clinical diagnosis.

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  • ltrasoundguided Interstitial Implant Brachytherapy for Moderately Advanced and Advanced Cervical Carcinoma

    摘要:目的:探讨超声引导下组织间插植内照射治疗中晚期宫颈癌的意义和效果。方法:回顾性分析32例中晚期宫颈癌患者,采用超声引导下肿瘤组织间插植内照射+外照射。结果:有23例肿瘤脱落,宫颈原形出现,其余7例肿瘤缩小50%以上,持续时间均≥1个月,另有2例肿块缩小<50%,即CR为719%,PR为218%,NC为63%,PD为0%。结论:超声引导下插植内照射是一种治疗中晚期宫颈癌的安全有效的近距离放疗技术。Abstract: Objective: To evaluate the efficacies of interstitial implant brachytherapy by ultrasoundguided for moderately advanced and advanced cervical carcinoma. Methods: Thirytwo patients with cervical cancer ⅡbⅣ who received interstitial implant brachytherapy by ultrasoundguided and routine irradiation. Results: 719% cases achieved complete remission (CR), 219% cases partial remission (PR), 63% cases no change(NC),0% case progressed disease(PD). Conclusion: Interstitial implant brachytherapy by ultrasoundguided is an effective method for cervical tumor.

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 多层螺旋CT在宫颈癌诊断及分期中的价值

    摘要:多层螺旋CT在宫颈癌的诊断、分期以及对手术切除的选择、术后监测、预后判断等方面具有重要的临床价值,尤其对进展期宫颈癌,应作为其临床分期的重要常规检查方法之一。尽管多层螺旋CT在显示早期宫颈癌原发灶方面的优势尚有限,但对于评价进展期宫颈癌优势突出,即可显示盆侧壁、输尿管、膀胱和直肠等侵犯,淋巴结肿大、盆腔外转移及治疗后有否肿瘤复发等,可为临床提供重要影像学信息。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 手术加综合治疗与同步放化疗治疗ⅡB期宫颈癌的比较

    摘要:目的:对比手术为主的综合治疗及同步放化疗治疗ⅡB期宫颈癌的疗效和并发症。方法:选择2001年1月至2008年4月收治的ⅡB期宫颈鳞癌患者147例,分为以手术为主的综合治疗组(72例,术前予紫杉醇为主的化疗,根治性手术后或需补充放疗)和同步放化疗组(75例,予顺铂为主的化疗,同步给予放疗),对两组患者的疗效及并发症发生情况进行对比分析。结果:手术组化疗有效率为73.6%,同步放化疗组有效率为70.6%,其5年生存率分别为81.9%和78.6%,手术组的并发症主要为血液毒性术后尿潴留和淋巴囊肿的发生,经对症处理短时间内痊愈。同步放化疗组的并发症主要为骨髓抑制和放射性直肠炎、膀胱炎、阴道挛缩,前者可痊愈,后者严重者甚至穿孔。结论:手术为主的综合治疗ⅡB期宫颈癌可明显提高患者有效率、5年生存率及生活质量。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • Clinical Analysis of 13 Patients with Cervical Cancer Associated with Pregnancy

    目的:探讨妊娠相关性宫颈癌的早期诊断、治疗和预后。方法:结合文献回顾分析我院2000年至2007年收治的13例妊娠相关性宫颈癌的诊治经过和预后。结果:妊娠相关性宫颈癌分化程度低,癌灶体积大,早期盆腔淋巴结转移率高,产褥期宫颈癌预后差。结论:宫颈细胞学检查应列为首次产检常规项目;妊娠期宫颈原位癌在密切随诊前提下可暂不予处理,待分娩后6~8周活检确认病变性质后,再采取相应治疗措施;新辅助化疗同样可为晚期别的妊娠相关性宫颈癌争取手术时机。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • The Expression of EphA2 in Cervical Cancer and the Relationship of Prognostic for Patients

    探讨宫颈癌中EphA2的表达及其临床意义。方法:应用免疫组织化学方法检测10例慢性宫颈炎、25例宫颈上皮内瘤样变(CIN)、50例宫颈癌(鳞癌41例、腺癌9例)中EphA2的蛋白表达。并对50例宫颈癌患者进行8~46月随访,分析EphA2在宫颈癌中的表达与患者预后的关系。结果:慢性宫颈炎、CIN、宫颈癌组织中EphA2蛋白阳性表达的差异有统计学意义(P<0.05)。EphA2蛋白在宫颈癌中的表达与患者年龄、FIGO分期、病理类型无关,与病理分级、有无淋巴结转移有密切相关性,且EphA2蛋白表达越强,患者生存率越低。结论:EphA2与宫颈癌的侵袭、转移密切相关,可望作为判断宫颈癌患者预后的参考指标。

    Release date:2016-09-08 10:14 Export PDF Favorites Scan
  • Safety and Efficacy of Laparoscopic Nerve-Sparing Radical Hysterectomy in the Treatment of Early Cervical Cancer: A Meta-Analysis

    Objective To assess the efficacy and safety of laparoscopic nerve-sparing radical hysterectomy (LNSRH) in treatment of early cervical cancer. Methods Such databases as CBM (1960 to September 2011), CENTRAL (1966 to September 2011), MEDLINE (1966 to September 2011), The Cochrane Library, EMbase (1974 to September 2011) and CNKI (1994 to September 2011) were searched on computer, and relevant magazines were also searched manually. Data were extracted and the quality was assessed after including studies according to exclusive criteria, then meta-analysis was conducted using RevMan 5.1 software. Results Total 7 studies involving 506 cases were selected, of which 255 cases were in the LNSRH group and the other 251 cases were in the laparoscopic radical hysterectomy (LRH) group. There were no differences between the two groups in age, body mass index, clinical stage, pathological type and histological grade. The results of meta-analysis showed that: a) The operative time of LNSRH was longer than LRH, with significant difference (P=0.02). But there was no significant difference in intraoperative bleeding between the two groups (P=0.69); b) The length of dissected parametrium of LNSRH was shorter than LRH with significant difference (P=0.02). But there was no significant difference in the length of dissected vagina (P=0.69); and c) The functional recovery of the bladder in the LNSRH group was better than LRH (Plt;0.000 01). Conclusion LNSRH is safe and feasible in effectively alleviating the postoperative dysfunction of the bladder in early cervical cancer as well as in improving the quality of life for patients. It is regarded as a new model of operation. Because it has just been put into practice within a short time, and there is lack of multi-center, large-sample, prospective controlled studies at present, so its radical effectiveness, long-term recurrence rate, survival rate, etc. have not yet been confirmed. More high quality studies are needed to provide important data of comparison between LNSRH and LRH.

    Release date:2016-09-07 10:59 Export PDF Favorites Scan
  • Analysis on Therapeutic Effects and Influencing Factors of Focused Ultrasound in 7027 Patients with Cervicitis Related Diseases

    Objective To explore the effectiveness, safety and applicability of focused ultrasound (FU) in rural patients with cervicitis-related diseases. Methods Patients with cervicitis-related diseases (n=8 352) from 80 township health centers of 9 counties in Chongqing were enrolled in this multicenter clinical study, and they were treated with CZF Model of FU for one time and then were visited in the following 3 months. According to the category 4 scoring method and the curative index, the effectiveness, safety and applicability in 7027 cases (1 156 mild cases, 5 312 moderate cases, 559 severe cases) with complete records were analyzed. The influencing factors were also analyzed with logistic regression analysis. Results A total of 6 413 cases (91.26%) were treated within 5 minutes. After 3-month follow-up, the total effective rate was 99.59%, and 5 012 cases (71.32%) were cured. Just little or medium amount of vaginal bleeding occurred in 656 cases (9.34%) after treatment, while only 12 cases (0.17%) had bleeding in the similar amount tomenstruation, which were relieved by hemostasis and anti-inflammatory treatment. Conclusion As a promising new therapy, focused ultrasound therapy for treating cervicitis-related diseases is safe and effective, with little postoperative bleeding and short-term of vaginal effusion, so it is suitable to be popularized in rural areas.

    Release date:2016-09-07 10:59 Export PDF Favorites Scan
  • Diagnostic Accuracy of Liquid-Based Cytology versus Conventional Cytology for Cervical Neoplasia: A Systematic Review of Randomized Controlled Trials

    Objective To evaluate the diagnostic accuracy of liquid-based cytology versus conventional cytology for cervical neoplasia. Methods Such databases as PubMed, Embase, The Cochrane Library, Cochrane Central Register of Controlled Trials, CNKI and CBM were searched to collect the random control trials (RCTs) about evaluating the diagnostic accuracy of liquid-based cytology versus conventional cytology for cervical neoplasia published before June, 2010. According to the inclusive and exclusive criteria, two assessors independently screened the studies, extracted the data, assessed the quality and conducted meta-analysis by using RevMan 5.0 and Metadisc 1.4 softwares. Results A total of five RCTS were eligible. With the ASCUS regarded as the abnormal critical value, there were significant differences between liquid-based cytology and conventional cytology in specificity for CIN 3+ (RR=0.97, 95%CI 0.97 to 0.97, Plt;0.000 01) and CIN 2+ of high risk population (RR=1.01, 95%CI 1.01 to 1.01, Plt;0.000 01), but no significant differences were found in other outcomes. Conclusion Based on the current evidence of evidence-based medicine, the liquid-based cytology is of neither more specificity nor more sensitivity for detecting high grade CIN than the convention cytology in the regular screening program, but it seems to be of more specificity in high risk group.

    Release date:2016-09-07 11:01 Export PDF Favorites Scan
  • Clinical Effect of Nerve Sparing Radical Hysterectomy for Cervical Cancer: A Systematic Review

    Objective To evaluate the clinical effect and safety of nerve sparing radical hysterectomy(NSRH) for cervical cancer compared with radical hysterectomy (RH). Methods We searched the Cochrane Library (Issue 2, 2010), MEDLINE (1960 to March, 2010), EMbase (1960 to March, 2010), CBM (1960 to March, 2010), VIP (1960 to March, 2010) and CNKI (1960 to March, 2010), and hand searched related literatures. With a defined search strategy, both randomized controlled trials and controlled clinical trials of comparing NSRH with RH for cervical cancer were identified. Data were extracted and evaluated by two reviewers independently. The quality of the included trials was evaluated by Cochrane’s evaluation criterion. Meta-analysis was conducted with the Cochrane collaboration’s RevMan 4.2.2 software. Results Nine controlled clinical trials involving 742 patients were identified. The meta-analysis showed that: a) There was statistical significance in postoperative recovery of bladder function between two groups; compared with RH, NSRH was much better in aspects of the recovery time of post void residual urine volume (PVR) (WMD= – 5.80, 95%CI – 6.22 to – 5.37), the bladder dysfunction morbidity (RR=0.43, 95%CI (0.26 to 0.75), and the urodynamic study; b) The operation time of NSRH was longer than that of RH with a significant difference (WMD=37.23, 95%CI 12.84 to 61.61); c) There was no significant difference between two groups in bleeding amount (WMD=19.66, 95%CI – 51.57 to 90.90); d) There was no significant difference between two groups in both survival rate and recurrent rate (RR=0.79, 95%CI 0.17 to 3.58); e) There was no significant difference between two groups in resection extension and pathologic outcome, such as, infiltration around uterus and vessels; f) One trail showed a significant difference between two groups that NSRH seldom led to anorectal and sexual dysfunction. Conclusions Compared with RH, NSRH can quickly improve the postoperative recovery of bladder, anorectal and sexual functions, but haven’t larger quantity of operative bleeding, larger resection extension, lower survival rates and higher recurrence rates except longer operation time. NSRH can improve the quality of postoperative life and is safe. However, the trails available for this systematic review were limited, as well as non-randomized controlled trails. Some outcomes were only included by one trail. So there is no confirmed conclusion about these. The prospective randomized controlled trials are required for further investigation.

    Release date:2016-09-07 11:12 Export PDF Favorites Scan
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