Objective To investigate the efficacy of basic fibroblast growth factor (bFGF) combined with topical oxygen therapy for deep II degree burn wounds, by comparing the effects of bFGF combined with topical oxygen therapy and bFGF with routine therapy. Methods From February 2004 to July 2009, 85 patients with deep II degree burn wounds (117 wounds) were enrolled and divided into 4 groups randomly according to different treatments. There was no significant difference in sex, age, disease course, wound size, and wound treatment size among 4 groups (P gt; 0.05). In group A, 18 patients (28 wounds) were treated routinely; in group B, 23 patients (30 wounds) were treated with routine methods and topical oxygen therapy; in group C, 19 patients (25 wounds) were treated with routine methods and bFGF therapy; and in group D, 25 patients (34 wounds) were treated with routine methods and bFGF/topical oxygen therapy. Topical oxygen therapy was administered to the wound for 90 minutes per day for 3 weeks. The bFGF therapy was appl ied everyday (150 U/ cm2) for 3 weeks. Results All cases were followed up 6-12 months (9 months on average). The wound heal ing times in groups A, B, C, and D were (27.3 ± 6.6), (24.2 ± 5.8), (22.2 ± 6.8), and (18.2 ± 4.8) days, respectively; showing significant difference between group A and group D (P lt; 0.05). The wound heal ing rates in groups A, B, C, and Dwere 67.8% ± 12.1%, 85.1% ± 7.5%, 89.2% ± 8.3%, and 96.1% ± 5.6%, respectively; showing significant differences between group A and groups B, C, D (P lt; 0.05). The therapic effective rates in groups A, B, C, and D were 75%, 90%, 92%, and 100%, respectively; showing significant difference between group A and group D (P lt; 0.05). The Vancouver scar scale scoring of group D 6 months after treatment was better than that of group A (P lt; 0.05). Conclusion The bFGF combined with topical oxygen therapy can enhance deep II degree burn wound heal ing. Furthermore, the therapy method is simple and convenient.
目的 观察可调节负压引流技术联合局部氧疗治疗腹部切口感染创面的临床效果。 方法 对2009年5月－2012年9月28例腹部切口感染创面患者使用可调节负压引流技术联合局部氧疗治疗，创口内填入负压吸附垫，持续输氧0.5～1 L/min，可调节负压采用连续工作模式，使密闭创面保持60～120 mm Hg（1 mm Hg=0.133 kPa）的负压状态，3～7 d更换负压吸附垫和引流管。 结果 28例切口创面感染得到控制。8例经一次治疗创面愈合，15例经2～4次治疗创面愈合，2例行Ⅱ期缝合，3例患者对贴膜过敏，治疗一次后改为换药治疗。28例患者创面愈合时间4～28 d，平均14 d，随访1～18个月无切口裂开，7例有凹陷瘢痕，余瘢痕平整。 结论 可调节负压引流技术联合局部氧疗治疗腹部切口感染创面，具有操作简便、安全可靠、疗效明显的优点，可加快创面愈合，缩短住院时间，提高切口的愈合质量，减轻患者痛苦及医务人员的工作量。