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"张宝仁" 21 results
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Abstract: Prosthetic valve endocarditis(PVE) is a catastrophic complication of cardiac valve replacement, associated with high mortality rates. In the past nearly five decades, the microbiology, pathophysiology, clinical features, and therapeutic options in PVE have changed a lot, and there are new insight into the pathogenesis of PVE. The current comprehensive review will address various issues involved in the diagnosis and management of this complication.
Release date：2016-08-30 06:13
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Objective To summarize the experiences of surgical treatment for periprosthetic leakage(PPL). Methods A total of 63 patients with PPL (mitral PPL in 34, aortic PPL in 29), age 41±12 years, underwent reoperation with prosthetic valve replacement from Dec. 1980 to Dec. 2005 in this department. Patient characteristics, operative profiles and follow-up data were described and analyzed in detail. Results The perioperative complications occurred in 11 patients (17.5%), five of whom died (the overall hospital mortality: 7.9%). Fifty-five patients were in close follow-up and three of them lost in that period, five patients died in late. Fifty patients long-term survivals were in New York Heart Association class Ⅰ-Ⅱ and follow-up evaluation by echocardiography showed no evidence of recurrence or residual PPL and PPL-related complications. Conclusion More attention should be paid to the study on etiology, pathophysiology, diagnostic methods, and clinical classification of PPL. For patients with PPL, reoperation with prosthetic valve replacement is considerably effective and can obtain an acceptable longterm results.
Release date：2016-08-30 06:15
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目的分析胸主动脉夹层术后复发的原因,总结其外科治疗经验。方法回顾分析4例主动脉夹层术后复发患者行手术治疗的临床资料,其中行Bentall手术2例,胸主动脉置换术2例。结果全组无手术死亡,术后并发呼吸及肾功能不全1例,声音嘶哑1例。结论胸主动脉夹层术后再发与原发病、血压控制不良、第1次手术适应证的选择有关,急性DeBakeyI、II型患者应行急诊手术治疗。
Release date：2016-08-30 06:25
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Objective To study effects of mitral valve replacement(MVR) on the old with mitral valve diseases(MVD). Methods The documents of 265 cases undergoing MVR were reviewed, who aged 60 years old or over between June 1991 and June 2003. Demographices, clinical preoperative conditions, indications to surgery, early postoperative course and long-term outcome were collected via hospital documents and outpatient follow-up. Many risk factors were analysed. Results Follow-up rate amounted to 93.7%(236/252). The mortality was 4.9% (13/265) within 30 days. Heart failure and renal failure were the main cause of death. Compared with younger patients(lt;60 years old), long-term survival rate was lower in the old, 5-year 87.52% vs 96.84%, 10-year 81.23% vs 94.87%. There were 15 late deaths(0.17% case/M), most of whom died of heart failure, cancers and lung infections. Risk factors for MVR in the old included New York Heart Association class Ⅳ, diabetes, and lung incompetence. Conclusions The patients with MVD over 60 years old tended to present high postoperatively mortality and morbidity.
Release date：2016-08-30 06:28
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目的 建立猪慢性心肌缺血模型,评价腺病毒载体的转染效率和持续时间. 方法 应用磷酸钙沉淀法制备携带大肠杆菌LacZ基因复制缺陷的重组腺病毒(Ad.LacZ),将健康家猪8条随机分为实验组和对照组,每组4条.两组猪均经左前外侧开胸,于冠状动脉左回旋支(LCX)放置Ameroid环, 28天后二次开胸,实验组:在缺血心肌部位每点直接注射Ad.LacZ 100μl,1010噬斑形成单位,共10点;对照组:在缺血心肌部位每点注射磷酸盐缓冲液(PBS)100μl,共10点.于注射后3天、7天和28天对缺血心肌进行染色和病理观察. 结果 冠状动脉造影证实LCX完全闭塞,心肌有缺血和小面积心肌梗死;实验组注射Ad.LacZ后第3天、7天和28天X-gal染色有阳性细胞,以7天时明显,对照组无阳性细胞. 结论 应用Ameroid环可成功建立猪慢性心肌缺血模型,腺病毒载体转染缺血心肌基因表达可持续4周.
Release date：2016-08-30 06:32
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目的 探讨先天性主动脉瓣二叶化畸形的诊断、适宜手术时机、围术期处理以及手术疗效. 方法 60例患者被施行心瓣膜置换术,行主动脉瓣机械瓣置换术56例,行自体心包瓣置换术4例;同时行主动脉窦瘤破裂修补术2例,胸主动脉瘤修补术2例,动脉导管未闭缝扎术3例,室间隔缺损修补术5例,冠状动脉旁路移植术3例.其中伴感染性心内膜炎25例. 结果 术后早期死亡5例,死亡率为8.3%.随访49例,平均随访时间5.4年,5年生存率为84.3%. 结论 先天性主动脉瓣二叶化畸形以男性居多,左、右二叶型较前、后型常见,可致主动脉瓣关闭不全和/或狭窄,以关闭不全多见(75%).出现充血性心力衰竭、心绞痛、晕厥、感染性心内膜炎时应尽早行手术治疗,症状不明显的患者应定期复查超声心动图,主动脉瓣置换术是常用的手术方法.
Release date：2016-08-30 06:32
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目的 为了提高同期施行冠状动脉旁路移植术(CABG)与心瓣膜手术的疗效,降低死亡率,总结手术及围术期处理的经验. 方法 24例患者中,二尖瓣病变11例,主动脉瓣病变3例,二尖瓣、主动脉瓣双瓣膜病变10例.1支冠状动脉病变1例,2支11例,3支6例,另6例为心瓣膜手术中发现左冠状动脉开口有阻塞,急症行CABG.全组行二尖瓣成形术 2例,二尖瓣置换术 9例,主动脉瓣置换术3例,二尖瓣、主动脉瓣双瓣膜置换术10例;移植1支血管7例,2支11例,3支6例. 结果 术后早期(30天内)死亡2例,分别死于低心排血量综合征和多器官功能衰竭.随访22例,随访时间8个月～7年,晚期死亡1例,其余21例心功能明显改善,心功能(NYHA分级)Ⅰ级15例,Ⅱ级5例,Ⅲ级1例,心绞痛消失7例. 结论 冠状动脉粥样硬化性心脏病和心脏瓣膜疾病并存时,应同期施行CABG和心瓣膜手术,彻底纠正心脏病变.术中加强心肌保护,尽量缩短心肌缺血时间;术后妥善处理心、肾等器官功能衰竭,是提高手术疗效的重要措施.
Release date：2016-08-30 06:31
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目的 总结升主动脉和弓部动脉瘤手术治疗经验,以期进一步提高手术疗效. 方法 自2000年7月至2002年5月应用深低温停循环(DHCA)和上腔静脉逆行脑灌注(RCP)技术手术治疗升主动脉和弓部动脉瘤20例,其中急症手术5例.施行全弓置换术2例,全弓置换和象鼻手术3例,半弓置换术15例.同期行Bentall手术8例,升主动脉置换术或同时行主动脉瓣置换术12例,冠状动脉旁路移植术1例. 结果 术后早期死亡1例,短时间浅昏迷1例,呼吸功能不全2例,肾功能不全2例,无晚期死亡. 结论 DHCA和RCP技术是手术治疗升主动脉和弓部瘤的安全、有效方法,急性A型夹层动脉瘤的手术方式取决于内膜破裂口的位置;正确掌握DHCA和RCP技术、手术方式和手术技术、围术期处理是提高手术疗效的关键因素.
Release date：2016-08-30 06:30
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目的 为了提高手术疗效,总结埃布斯坦综合征(Ebstein syndrome)合并预激综合征的手术治疗经验. 方法 11例患者均有埃布斯坦综合征及严重三尖瓣关闭不全,合并A型预激综合征4例,B型 7例.术中电生理标测显示11例中有12条附加旁道,右心室游离壁6例,左心室游离壁3例,后间隔1例,后间隔和右心室游离壁双旁道1例.所有患者的房室附加旁道均在体外循环下被成功地手术切割;埃布斯坦综合征按Danielson方法行成形术9例,三尖瓣置换术2例. 结果 全组11例无手术后早、晚期死亡;术后随访4个月～6年,平均随访3.4±1.3年,无预激综合征复发,2例有轻度三尖瓣关闭不全.心功能Ⅰ级9例,Ⅱ级2例. 结论 手术治疗埃布斯坦综合征合并预激综合征,可同时纠正埃布斯坦综合征伴三尖瓣关闭不全和预激综合征,治疗效果良好.
Release date：2016-08-30 06:32
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目的 探讨左心房粘液瘤的诊断和治疗经验,以提高手术疗效. 方法 回顾性分析自1995年10月至2001年10月收治57例左心房粘液瘤病例,术前均经彩色超声心动图确诊,均在体外循环下行粘液瘤摘除术,同期行二尖瓣成形术5例,二尖瓣机械瓣置换术2例,三尖瓣成形术37例,房间隔缺损修补术2例,隔膜型主动脉瓣下狭窄环切开术1例. 结果 无围术期及手术死亡,随访1个月～6年,2例复发再次手术,捶⒙?.5%. 结论 左心房粘液瘤一经确诊应尽快手术,手术效果满意,复发率低;彩色超声心动图对诊断及术后随访有重要作用,应注意术后随访.
Release date：2016-08-30 06:32
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