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find Author "张海波" 40 results
  • 低温保护时心肌快速冷挛缩的研究进展

    心肌低温保护时快速冷挛缩(rapid cooling contracture,RCC)现象近来日益受到人们重视。快速冷挛缩现象是指快速制冷诱发的非去极化的心肌挛缩。其机制可能与心肌细胞内温度依赖性Ca2+快速升高有关。降温过程中,肌浆网内存Ca2+迅速释放,并与肌钙蛋白相结合,引起蛋白构象发生变化,通过粗、细肌丝相对滑行而产生心肌收缩。快速冷挛缩的危害为能量的消耗、冠状血管阻抗增大、心脏功能降低、Ca2+超负荷等方面,尤其对于未成熟心肌危害更大。目前有些学者提出用心肌温保护和预防Ca2+超负荷等方法来避免其危害的发生。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • Chinese expert consensus on surgical treatment of congenital heart disease (11): Coarctation of the aorta and interrupted aortic arch

    Coarctation of the aorta and interrupted aortic arch are congenital anomalies affecting the aortic arch. Because of the poor natural prognosis, many patients will need early surgical repair or even emergency surgery. With the improvement of the surgical techniques, cardiopulmonary bypass techniques and perioperative intensive care, surgical mortality has now dramatically decreased. However, aortic arch restenosis, left ventricular outflow tract obstruction and long-term hypertension are problems that may be still encountered during the follow-up period. By reviewing large amounts of literature and discussing among experts, we achieved a consensus on many aspects of the management strategy. We hope this consensus will help Chinese colleagues further improve the overall surgical outcomes of coarctation of aorta and interrupted aortic arch.

    Release date:2020-12-07 01:26 Export PDF Favorites Scan
  • 第四届安贞心脏瓣膜介入治疗新技术高峰论坛暨心脏全瓣膜介入技术Workshop培训工坊会议纪要

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  • The Partial Application of Complete Flexible Artifical Ring in Mitral Valve Repair

    Objective To summarize the experience and results of mitral annuloplasty with modified partial flexible artificial ring. Methods Two hundred and fifteennine patients were underwent partial flexible ring annuloplasty after mitral valve plasty surgery in our hospital from an. 1998 to Aug.2006. The etiology included rheumatic (16 cases), infective endocarditis of mitral (16 cases), ischemic (13 cases), ongenital (40 cases) and degeneration (174 cases). Echocardiogram test were performed in the perioperative periods to monitor the lefe atrium (LA), left ventricular enddiastolic dimension (LVEDD), left ventricular endsystolic dimension (LVESD), left ventricular ejection fraction(LVEF), left ventricular fractional shortening (LVFS) and mitral regurgitation grades. The perioperative mortality, morbidity, reoperation rate were recorded during the followup. Results Aortic cross clamping time was 74±30 min and cardiopulmonary bypass time was 105±37min. The perioperative survival rate was 96.5% (250/259) and free from complications rate was 93.4% (242/259). No left ventricular out flow tract obstruction and coronary artery stenosis were occurred in this group. The 60 months survival rate was 938% (243/259) and 5 years nonreoperation rate was 96.1%(249/259). The perioperative echocardiogram results showed the LVEDD decreased from 62.60±10.19mm to 52.88±8.67mm and the LVEF increased from 57.91% to 61.00%(Plt;0.05). During the followup the mitral regurgitation grades were improved significantly (Plt;0.05),there were 188 cases of trifle mitral regurgitation (72.6%), 62 cases of mild mitral regurgitation (23.9%), 8 cases of moderate mitral regurgitation(3.1%) and 1 case of serious mitral regurgitation(0.4%). Conclusion This simplified mitral annuloplasty technique is an easy handling and effective treatment for the mitral repair.

    Release date:2016-08-30 06:08 Export PDF Favorites Scan
  • 一期手术纠治主肺动脉窗及伴发畸形

    目的 总结一期手术纠治主-肺动脉窗及伴发畸形的临床经验,以提高手术疗效。 方法 我科共收治26例主-肺动脉窗患者,男14例,女12例;年龄1.4±1.6岁;体重7.8±3.8kg。其中单纯主-肺动脉窗8例,合并主动脉弓中断、右肺动脉异常起源于主动脉、法洛四联症、房间隔缺损、室间隔缺损、二尖瓣反流和气管狭窄等18例。25例患者一期手术经主动脉切口补片关闭瘘口纠治主-肺动脉窗,同时纠治伴发的畸形;1例放弃治疗。 结果 全组无手术死亡。2例伴主动脉弓中断、动脉导管未闭和右肺动脉起源于升主动脉的新生儿术后3d延迟关胸;1例术后出血,3h后再次开胸止血。术后随访22例,随访时间1个月~4年。所有患者无明显的主动脉瓣上狭窄和肺动脉分支狭窄,2例残留轻度二尖瓣反流,1例残留轻至中度二尖瓣反流。 结论 主-肺动脉窗患者早期易发生肺动脉高压,一经诊断应立即手术。手术方式首选修补主肺动脉窗及一期纠治伴发畸形。尽管主-肺动脉窗可合并各种心内外畸形,但早期手术纠治可获得较好的中长期疗效。

    Release date:2016-08-30 06:09 Export PDF Favorites Scan
  • Surgical Treatment of Sinus Venosus Atrial Septai Defect

    Objective To summarize the experiences of surgical treatment of sinus venosus atrial septal defect (SVASD). Methods There were 32 patients of SVASD, all of them were associated with totally or partially right anomalous pulmonary venous connection. There were 25 cases of superior SVASD, 22 cases underwent double-patch procedure, 3 cases underwent Warden procedure. In 7 cases of inferier SVASD, 3 cases of Scimitar syndrome underwent ASD repair by pericardial patch and at the same time the anomalous pulmonary vein was divided and reimplanted to the posterior wall of left atrium, 4 cases of them underwent single-patch ASD repair. Results The surgical results were satisfying and no patient died, 28 patients were in sinus rhythm and echocardiography showed neither obstruction of caval vein and right pulmonary vein nor residual interatrial shunt. Conclusion SVASD mostly associated with right anomalous pulmonary venous connection according to its special anatomic structure. Preserving the function of sinus node and avoiding of obstruction of caval vein should be routinely considered when superior SVASD was repaired. The heart function of Scimitar syndrome should be followed-up for a long time for it usually associated with right lung hypoplasia.

    Release date:2016-08-30 06:18 Export PDF Favorites Scan
  • Single Stage Repair of Interrupted Aortic Arch with Associated Cardiac Anomalies

    Abstract:Objective To summarize the experiences of single stage repair of interrupted aortic arch (IAA) associated with cardiac anomalies. Methods From Jan. 2000 to Dec. 2005, 48 patients admited in hospital and 35 patients were operated, the mean age at operation was 1.1 years. The associated anomalies included 23 cases of ventricular septal defect, 2 cases of transposition of great arteries, 3 cases of aortopulmonary window with aortic origin of right pulmonary artery, 2 cases of truncus arteriosus, 2 cases of double outlet right ventricle, 2 cases of stenotic fifth arch and 1 case of aberrant origin of right subclavian artery with mild hypoplastic decending aorta. Among them, 34 patients underwent single stage repair and 1 kid underwent palliative correction. Results There were 4 surgical deaths. The sequelae included one diaphragm paralysis and one 3rd degree of atrioventricular block. Only 5 kids recurred mild stenosis of aortic arch anastomosis and 2 death occurred during 3 months to 4 years of follow-up. Conclusion Though early surgical mortality for primary single stage repair is now relatively low, if appropriate interventions has been accomplished during perioperative period, but outcomes of IAA remain of concern, especially in patients with associated lesions.

    Release date:2016-08-30 06:23 Export PDF Favorites Scan
  • Cryopreserved Homograft Pericardium Patch in Staged Repair of Tetralogy of Fallot

    Objective To compare the difference of effect while using homograft pericardium patch and Gore- tex patch in staged repair of tetralogy of Fallot(TOF) to enlarge the right ventricular outflow tract (RVOT). Methods Twenty-eight patients with TOF who underwent the staged complete repair were divided into 2 groups according to the date of surgery. Gore-rex group, 13 cases, their RVOT were enlarged with Gore-tex patches. Cryopreserved homograft pericardium patch group, 15 cases, their RVOT were enlarged with cryopreserved homograft pericardium patches. Clinical results and follow-up results were compared. Results There were 1 operative death in Gore-tex patch group (7. 7%), and 1 early postoperative death in cryopreserved homograft pericardium patch group (6. 7%). Hemostasia time, the pericardial cavity drainage volume in cryopreserved homograft pericardium patch group were less than those in Gore-tex patch group (P〈0. 01). All patients were followed-up for 0.8-4.5years. The residual obstruction rate at RVOT level in Gore-tex patch group was higher than that in cryopreserved homograft pericardium patch group by echocardiography (P〈0.01). No calcification shadow was found on the chest X-ray. Conclusion Homograft pericardium is the tissue with high density and intensity, its elasticity and compliance are good. Using homograft pericardium patch may be helpful to decrease the residual obstruction of RVOT after operation. It can be adapted as a repairing material in heart surgery.

    Release date:2016-08-30 06:26 Export PDF Favorites Scan
  • L-精氨酸对乳猪深低温停循环脑代谢与结构的影响

    目的 通过深低温停循环(DHCA)转流模型,研究左旋精氨酸(L-arg)在低温缺血时对脑代谢和结构的影响. 方法 采用上海种白猪,3~4周龄,随机均分成4组: L-arg组,左旋硝基精氨酸甲酯(L-NAME)组, L-arg+L-NAME组和对照组,每组10只.按临床方法行心肺转流术,于转流前、降温末、复温末和转流结束等分别测定颈内静脉一氧化氮(NO)、脑皮质三磷酸腺苷(ATP)和颈内静脉乳酸含量.并行脑组织学和超微结构观察. 结果 降温末L-NAME组和对照组NO含量较其它两组明显下降(Plt;0.01).复温末,除L-NAME组外,其余3组均恢复至转流前水平(Plt;0.01),L-arg组NO水平在复温末较转流前高(Plt;0.01). 转流开始后大脑皮质ATP即有明显下降,L-arg组下降幅度最小,且在复温末已接近转流前水平;L-NAME组下降幅度最大(Plt;0.01). 转流开始后颈内静脉乳酸含量即升高,L-arg组和L-arg+L-NAME组上升幅度较小;降温末和转流结束乳酸含量较其它两组低(Plt;0.01). 大脑皮质组织学和超微结构检查显示,大脑皮质细胞结构变化L-arg组和L-arg+L-NAME组较对照组和L-NAME组轻. 结论 深低温停循环手术时,应用L-arg具有较好的脑保护作用,而L-NAME有脑损害作用.L-arg可部分逆转DHCA时L-NAME对脑组织的损害作用.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • 膜式氧合器在胎羊体外循环中的运用

    目的 为了改进胎羊体外循环技术,探讨膜式氧合器在胎羊体外循环中的应用. 方法 将健康怀孕山羊8只,采用Dideco 901膜式氧合器和滚轴泵建立胎羊体外循环,常温(37℃)转流60分钟,氧合器内充低氧混合气体(8% O2和92% N2),监测胎羊的血压、心率、血气、血清乳酸和胎盘血管阻力. 结果 胎羊体外循环中动脉氧分压(PO2)和二氧化碳分压(PCO2)维持在宫内生理水平,胎羊心搏有力,血压正常.但胎羊pH值缓慢下降(P<0.05),血清乳酸值明显增高(P<0.01),胎盘血管阻力显著上升(P<0.01).停体外循环后胎羊出现低氧、高碳酸血症和酸中毒. 结论 胎羊体外循环影响胎盘功能,膜式氧合器可以代替胎盘气体交换功能,体外循环中胎羊生理低水平PO2是否适合其需要值得探讨.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
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