Epithelial membrane protein (EMP) 2 is one of the seven proteins in the EMP gene family and is a tissue-specific transmembrane protein. Recent studies have shown that it exhibits different expression patterns in different tumor tissues and exhibits differentiated manifestations in the invasion and metastasis of different tumors, such as promoting or inhibiting them. Based on these characteristics, progress has been made in the field of anti EMP2 therapy, such as the development of monoclonal antibodies, which may bring new avenues for cancer treatment. Based on this, this article reviews the research progress of EMP2 in tumor invasion and metastasis, in order to provide ideas for determining new tumor targets.
In the process of solid tumor transformation, the expression of claudins is often dysregulated. Claudins are involved in almost all aspects of tumor biology and steps of tumor development, suggesting that they have the potential to be diagnostics, and prognostic biomarkers and therapeutic targets. Current studies have found that Claudin18.2 is overexpressed in gastric cancer, pancreatic cancer, ovarian cancer and other diseases. Targeted anti-tumor therapy based on Claudin 18.2 has become a research hotspot recently. Therefore, this article reviews the basic structural characteristics of Claudin18.2, its expression in various malignant solid tumors, the progress of research and application, and prospect.
ObjectiveTo study the survival rate and death cause of patients with polymyositis (PM) and dermatomyositis (DM). MethodsBased on the Bohan and Peter diagnosis standard, DM (n=52) and PM (n=98) hospitalized patients between January 1, 2008 and January 1, 2013 were chosen to be followed up to January 2013, or to their death. Sex, age, disease entities, course of the disease, muscle creatine enzyme, interstitial lung disease, connective tissue diseases, lung infection, cardiac involvement, respiratory muscle paralysis, JO-1 antibody, hypoalbuminemia, tumor, and long-term hormone and immune inhibitor treatment were the influencing factors of death. ResultsThirty-eight patients died during the follow-up period, and the 1-, 3- and 5-year survival rate were 87.7%, 74.5% and 55.9% respectively. Cox regression analysis showed that interstitial pneumonia (RR=12.119, P=0.001), heart disease (RR=2.935, P=0.020) and tumor (RR=3.735, P=0.048) were the unfavorable factors of death, while long-term hormones (RR=0.329, P=0.024) and persistent immunosuppressant therapy (RR=0.148, P=0.022) were protective factors. ConclusionThe five-year survival rate of patients with PM/DM is still low, and pulmonary interstitial disease, tumor, cardiac involvement, and pulmonary infection are the major dead causes, while long-team immunosuppression and hormone therapy can decrease the PM/DM mortality.
ObjectiveTo explore the impact of different tracts on the effectiveness and safety of percutaneous nephrolithotomy (PCNL) on complete staghorn calculus.MethodsPatients with complete staghorn calculus who underwent single channel PCNL by the same surgeon in West China Hospital of Sichuan University from October 2009 to August 2019 were included. The removing time, the rate of immediate stone removal, the average extubating time, and the incidences of postoperate complications such as fever and bleeding were analyzed statistically.ResultsA total of 379 patients were included. There were 146 cases in the upper tract group, 170 cases in the lower tract group and 63 cases in the middle tract group. Compared with the upper and middle tract groups, the lower tract group had shorter stone removing time [(50.34±18.52) vs. (53.41±22.75) vs. (41.79±17.45) min, P<0.001], shorter average extubating time [(5.53±1.83) vs. (6.17±1.44) vs. (4.96±1.91) d, P=0.007]. The rate of immediate stone removal was higher in the the upper tract group (40.56% vs. 32.79% vs. 34.71% ), but there was no statistical difference among the three groups (P=0.447). There was no significant difference among the three groups in the fever incidence (25.44% vs. 24.24% vs. 26.85%, P=0.938) or bleeding incidence (3.54% vs. 3.03% vs. 4.03%, P=1.000). In addition, there were 8 cases of pleural injury in the upper tract group.ConclusionsCompared with the lower and middle tract, PCNL with upper tract has a higher rate of removing stones for complete staghorn calculus, but there was no significant difference among the three groups. The incidences of bleeding and fever after surgery are similar in the three groups, but the risk of pleural injury may be increased in the upper tract group.
【摘要】 目的 采用高分辨率超声测定类风湿关节炎（rheumatoid arthritis，RA）患者颈动脉内中膜厚度和是否有斑块以及是否存在动脉硬化。 方法 分析2009年4月—2010年9月间150例RA患者的一般情况、发病情况、疾病活动性评分（DAS28评分），及实验室指标如:血沉（ESR）、C反应蛋白（CRP）、抗环瓜氨酸抗体（ACCP）、类风湿因子（RF）、总胆固醇、三酰甘油、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1 （ApoA1）、载脂蛋白B（ApoB）、脂蛋白a及血尿酸的测定。采用颈动脉彩色多普勒超声测定RA患者与正常对照组120例颈动脉内中膜值及是否有斑块。 结果 150例RA患者20例出现动脉硬化，120例健康人群中3例出现动脉硬化，RA颈动脉内硬化危险因素单因素分析中，病程、DAS28评分、ApoA1、ApoB、HDL-C及尿酸与RA动脉硬化有关，而年龄、性别、ESR、CRP、RF、ACCP等与RA发生动脉硬化无关；RA动脉硬化多因素回归分析示:病程、尿酸及高密度脂蛋白是RA发生动脉硬化的危险因素。 结论 颈动脉内中膜测定对RA动脉硬化具有一定临床价值。【Abstract】 Objective To detect the carotid artery intima-media thickness and the existence of carotid plague and arteriosclerosis by high-resolution ultrasonography in patients with rheumatoid arthritis (RA). Methods A total of 150 RA patients treated in our hospital between April 2009 and September 2010 were included in this study. Their general condition, onset of the disease and disease activity score (DAS28 scoring) were analyzed. Laboratory indexes like erythrocyte sedimentation rate (ESR), C reactive protein (CRP), Anti-cyclic citrullinated peptide (ACCP) antibody, rheumatoid factor (RF), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), lipoprotein(a) (Lp(a)), and uric acid (UA) were measured. Carotid color ultrasonography was used to detect the carotid intima-media thickness and the existence of carotid plague in 150 patients with RA and 120 patients in the control group. Results Twenty out of the 150 RA patients and three out of the 120 controls manifested arteriosclerosis. Single factor analysis showed a correlation between arteriosclerosis in RA patients and course of disease, DAS28 scoring, Apo A, Apo B, HDL-C, and UA, and no correlation between arteriosclerosis and age, gender, ESR, CRP, RF, and ACCP. Multivariate regression analysis showed that the course of disease, UA and HDL-C are independent risk factors for arteriosclerosis in RA patients. Conclusion Analysis of the carotid intima-media has a certain clinical value in predicting arteriosclerosis in RA patients.
The study aimed to evaluate the safety and function of poly(lactic-acid-co-ε-caprolactone) (PLCL)/fibrinogen nanofibers (P/F-Ns), and provide theoretical basis for the clinical application. The surface morphology, mechanical properties, the hydrophilicity and the fibrinogen content of P/F-Ns were tested by scanning electron microscope, the material testing machine, the contact angle meter and the microplate reader, respectively. The cell adhesion, proliferation and ligament remodeling genes expression of Hig-82 cells on P/F-Ns were conducted through cell counting kit-8 (CCK-8) and real-time quantitative PCR analyses, respectively. The results showed that with the increase of the fibrinogen content, the pore sizes and hydrophilicity of three P/F-Ns increased, but the mechanical properties decreased. Cell adhesion and proliferation tests showed that P/F-N-2 held the best ability to promote cell adhesion and proliferation. The ligament remodeling genes expressions of Hig-82 cells on P/F-N-1, P/F-N-2 and P/F-N-3 were all up-regulated compared to P/F-N-0 on days 3 and 7. All the three P/F-Ns containing fibrinogen (P/F-N-1, P/F-N-2 and P/F-N-3) had better biocompatibility compared to P/F-N-0, and could be efficiently applied to the reconstruction of anterior cruciate ligament.