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find Author "张茹珂" 2 results
  • 白细胞介素-33在自身免疫性疾病发病机制中的作用研究进展

    自身免疫性疾病(AID)是由自身免疫应答引起的慢性炎症性疾病,该类疾病大多数原因不明,可能与遗传、感染及环境等因素有关。白细胞介素-33(IL-33)作为一种炎性细胞因子,通过IL-33/ST2信号通路调节免疫应答,从而参与疾病的发生和发展。AID的病程一般较长并反复迁延,临床治疗困难。研究IL-33与AID之间的关系,为AID致病机理的研究、疾病的诊断和治疗提供新的方向。

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  • The Study of Laboratory Tests and Clinical Characteristics of Systemic Lupus Erythematosus Subtype Based on a SLE Family

    ObjectiveSystemic lupus erythematosus (SLE) patients from a SLE family with homogeneity can provide experimental basis for individualized diagnosis and treatment by studying the characteristics of laboratory tests and symptoms. MethodsLaboratory tests were analyzed for three SLE patients in the family, and set up the screen model by three laboratory tests (anitnuclear antibody positive, rheumatoid factor positive and IgE positive, ANA+RF+IgE+). All SLE cases were screened from latest four years as SLE subtype patients (named "similar family SLE patients"), then the family laboratory tests and clinical characteristics were analyzed. ResultsA total of 55 patients (6.27%) were screened as similar family SLE patients from individual SLE patients according to model from 877 cases. The laboratory tests of similar family SLE patients including creatinine, WBC, CRP were significant lower than other SLE patients (P < 0.05), but significant higher for the IgG, positive rate of anti-SSA and anti-SSB (P < 0.05), and the alopecia and skin rashes were more common in similar family SLE patients than other SLE patients. ConclusionsThe ANA+RF+IgE+ SLE patients are of lower inflammatory state and kidney involvement; Clinical symptom is priority to alopecia and skin rashes.

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
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