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find Author "张蔷" 3 results
  • Clinical Significance of Serum A-FABP in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

    Objective To investigate the relationship between adipocyte fatty acid binding protein ( A-FABP) and obstructive sleep apnea hypopnea syndrome ( OSAHS) . Methods A total of 120 patients were recruited and underwent polysomnography. The groups were allocated according severity of OSAHS and obesity. Plasma A-FABP ( ng/mL) levels were measured by ELISA. The associations between A-FABP and AHI, BMI, LSaO2 , MSaO2 , neck collar, waist /hip ratio, insulin resistance index were analyzed. Results Plasma A-FAPB levels were significantly higher in the OSAHS group than in the non-OSAHS group of same weight, independent of age and gender. In the non-OSAHS group and the severe OSAHS group, plasma A-FABP levels of obesity persons were significantly higher than those without obesity, independent of age and gender. Plasma A-FAPB level was positively correlated with AHI, BMI, insulin resistance index, neck collar, SLT90% , and waist/hip ratio, but negatevely correlated with LSaO2 and MSaO2 in the OSAHS group. In the non-OSAHS group, plasma A-FAPB level was positively correlated with BMI and insulin resistance index. Conclusions Plasma A-FABP level is higher in patients with severe OSAHS. Plasma A-FABP level is positively correlated with BMI and insulin resistance index both in OSAHS and non-OSAHS patients.

    Release date:2016-08-30 11:56 Export PDF Favorites Scan
  • 聚丙烯网状补片加强缝合辅助修复人工全膝关节置换术髌腱断裂三例

    目的总结聚丙烯网状补片加强缝合辅助修复 3 例人工全膝关节置换术(total knee arthroplasty,TKA)髌腱断裂的远期疗效。方法2007 年 8 月—2009 年 7 月,3 例类风湿性关节炎患者于 TKA 术中或术后发生髌腱断裂。其中男 1 例,女 2 例;年龄分别为 58、63、69 岁。2 例有类固醇长期使用史。经 Krackow 法缝合(1 例)或自体肌腱重建(2 例)后,采用聚丙烯网状补片加强固定。记录并比较患者重建术后伸膝迟滞、股四头肌肌力、膝关节活动度和膝关节学会评分系统(KSS)评分。结果术后患者分别获随访 10.4、11.0、6.5 年。随访期间无感染和假体松动发生。末次随访时,TKA 术中髌腱断裂患者膝关节 KSS 评分达 90 分,未见伸膝迟滞;术后髌腱断裂患者膝关节 KSS 评分达 90、85 分,残留伸膝迟滞 5°、10°。结论TKA 髌腱断裂后选择聚丙烯网状补片加强缝合辅助修复,患者远期膝关节功能良好,但应用例数有限,其确切疗效仍需扩大病例数量进一步验证。

    Release date:2020-09-28 02:45 Export PDF Favorites Scan
  • Effects of Cardioselective Beta-Blockers on Respiratory Function in COPD Patients:A Meta-Analysis

    Objective To evaluate the effects of cardioselective beta-blockers on respiratory function in patients with chronic obstructive pulmonary disease ( COPD) . Methods We used computer to search the Cochrane Controlled Trials Register database, Medline, Netherlands EMBASE/Excerpta Medica,EBSCO database, China Academic Journal and the Chinese Biomedical Literature Database, as well as respiratory magazines and conference abstracts, without language restrictions. The information was retrieved until December 2011. We collected all the randomized, blinded, controlled clinical trails ( RCTs ) of cardioselective beta-blockers on respiratory function in patients with COPD. Then two evaluators evaluated the quality of RCTs according to the Cochrane Review Manual 4. 2 independently. Meta-analysis was performed using statistical software Stata 11. 0. X2 test was used to analyze their heterogeneity. Standardizedmean difference ( SMD) was used to describe continuous variables. Relative risk degree ( RR) was used to describe categorical variables, and 95% CI was used to describe treatment effect. Results 22 trails met the selection criteria. Meta-analysis showed no change of FEV1 in COPD patients after taking single dose of cardioselective beta-blockers [ SMD - 0. 367, 95% CI( - 0. 786, 0. 052) ] and no respiratory symptoms aggravation [ RR1. 000, 95% CI( 0. 848, 1. 179) ] . Meta-analysis also showed no change of FEV1 in COPD patients who received long-term cardioselective beta-blockers treatment [ SMD - 0. 236, 95% CI( - 0. 523,0.051) ] , and no respiratory symptoms aggravation [ RR 1. 000, 95% CI ( 0. 830, 1. 205) ] . Inhaled beta-2 agonists showed no effect on FEV1 in COPD patients after either long-term administration [ SMD - 0. 200,95% CI( - 0. 586, 0. 187) ] or single dose administration of cardioselective beta-blockers [ SMD - 0. 078,95% CI( - 0. 654, 0. 497) ] . Conclusion Cardioselective beta-blockers, given to patients with COPD in conditions such as heart failure, coronary artery disease and hypertension in the identified studies did not produce adverse respiratory effects.

    Release date:2016-09-13 03:50 Export PDF Favorites Scan
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