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find Author "徐磊" 14 results
  • Application of Myocardial Contrast Echocardiography in Evaluation of Viable Myocardium

    Progress in the treatment of acute myocardial infarction (AMI), chronic coronary artery disease and their immediate complications has led to an increasing number of surviving patients with residual left ventricular dysfunction. It has been shown that viable myocardium in post-AMI patients and chronic heart failure patients plays an important role in predicting their prognosis and making clinical decisions. Viable myocardium refers to myocardium with reversible contractile dysfunction that occurs in coronary ischemia or after ischemia-reperfusion, but still has contractile reserve. Myocardial microvascular integrity is in correspondence with myocardial viability. Myocardial contrast echocardiography can evaluate the microvascular integrity of myocardial dysfunctional areas in patients with AMI or chronic coronary artery disease, detect viable myocardium, predict the potential for functional recovery in dysfunctional areas following reperfusion, and provide clinicians with valuable information for individualized treatment.

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
  • Expression of hepatocyte growth factor receptor in human epiretinal membranes and RPE cells

    Objective To investigate the expression of hepatocyte growth factor receptor (HGFR) in epiretinal membranes (ERM) of eyes with proliferative vitreoretinopathy (PVR) and cultured retinal pigent epithelium (RPE) cells. Methods Fifteen human epiretinal membranes were obtained from eyes undergone vitrectomy for rhegmatogenous retinal detachment complicated with PVR and observed by immunohistochemical examination to study the expression of HGFR. Using the immunohistochemical technique to evaluate the expression of HGFR in cultured RPE cells. Results In 6 membranes of PVR-grade C, HGFR were expressed in 5/6, and 7 cases were detected in 9 membranes of PVR-grade D.RPE cells express readily detectable levels of HGFR. Conclusion The findings indicate that HGF might be involved in the formation of epiretinal membranes in PVR. (Chin J Ocul Fundus Dis, 2002, 18: 221-223)

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
  • Mental Fatigue Electroencephalogram Signals Analysis Based on Singular System

    In the present paper, the contribution of the largest principal component and the number of principal component needed for accumulative contribution 95% are selected as indices of electroencephalogram (EEG) in mental fatigue state in order to investigate the relationship between these parameters and mental fatigue. The experimental results showed that the contribution of the largest principal component of EEG signals increased in the prefrontal, frontal and central areas, while the number of principal component needed for accumulative contribution decreased by 95% with the increasing mental fatigue level. The parameters of singular system of EEG signals can be regarded as useful features for the estimation of mental fatigue and have larger application value in the study of mental fatigue.

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  • APPLICATION OF BUTTERFLY SHAPED LOCKING COMPRESSIO PLATE IN COOMPLEX DISTAL RADIUS FRACTURES

    ObjectiveTo investigate the effectiveness of butterfly shaped locking compression plate for the treatment of complex distal radius fractures. MethodsBetween June 2011 and January 2013, 20 cases of complex distal radius fractures were treated with butterfly shaped locking compression plate fixation. There were 11 males and 9 females with an average age of 54 years (range, 25-75 years). Injury was caused by falling in 10 cases, by traffic accident in 7 cases, and by falling from height in 3 cases. All of fractures were closed. According to AO classification system, there were 8 cases of type C1, 8 cases of type C2, and 4 cases of type C3. Of them, 9 cases had radial styloid process fracture, 4 cases had sigmoid notch fracture, and 7 cases had both radial styloid process fracture and sigmoid notch fracture. The mean interval between injury and operation was 5.2 days (range, 3-15 days). ResultsAll incisions healed by first intention; no complications of infection and necrosis occurred. All cases were followed up 14 months on average (range, 10-22 months). All factures healed after 9.3 weeks on average (range, 6-11 weeks). No complications such as displacement of fracture, joint surface subsidence, shortening of the radius, and carpal tunnel syndrome were found during follow-up. At last follow-up, the mean palmar tilt angle was 10.2°(range, 7-15°), and the mean ulnar deviation angle was 21.8°(range, 17-24°). The mean range of motion of the wrist was 45.3°(range, 35-68°) in dorsal extension, 53.5°(range, 40-78°) in palmar flexion, 19.8°(range, 12-27°) in radial inclination, 26.6°(range, 18-31°) in ulnar inclination, 70.2°(range, 45-90°) in pronation, and 68.4°(range, 25-88°) in supination. According to the Dienst scoring system, the results were excellent in 8 cases, good in 10 cases, and fair in 2 cases, and the excellent and good rate was 90%. ConclusionTreatment of complex distal radius fractures with butterfly shaped locking compression plate can reconstruct normal anatomic structures, especially for radial styloid process and sigmoid notch fractures, and it can get good functional recovery of the wrist and the distal radioulnar joint.

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  • 尺骨远端钩形锁定钢板治疗尺骨远端不稳定骨折

    目的探讨应用尺骨远端钩形锁定钢板(locking compression plate-distal ulna hook plate, LCP-DUHP)治疗尺骨远端不稳定骨折的临床效果。 方法2013年1月-2014年7月,采用切开复位、LCP-DUHP内固定治疗13例尺骨远端不稳定骨折。男8例,女5例;年龄21~72岁,平均45岁。单纯尺骨远端骨折7例,均为直接暴力致伤,其中开放性损伤3例(GastiloⅡ型1例、Ⅲ型2例);桡骨远端合并尺骨远端骨折6例,均为摔伤。尺骨远端骨折均累及下尺桡关节水平,根据改良Q分型标准:Q2型7例,Q3型3例,Q4型2例,Q5型1例。受伤至内固定手术时间为3~14 d,平均7.69 d。 结果术后患者切口均Ⅰ期愈合。12例患者获随访,随访时间12~24个月,平均19.7个月。X线片检查示,除1例开放性尺桡骨远端粉碎性骨折未达解剖复位标准外,其余患者骨折均达解剖复位。所有骨折均愈合,愈合时间为10~20周,平均12.6周。末次随访时,臂-肩-手功能障碍评分(DASH)为0~36分,平均10.33分。 结论应用LCP-DUHP治疗尺骨远端不稳定骨折,可以提供稳定的固定效果,操作简便,但需注意其放置的安全范围。

    Release date:2016-10-02 04:55 Export PDF Favorites Scan
  • Factors influencing pulmonary complications after liver transplantation and the construction of a predictive model

    Objective To investigate the factors influencing the occurrence of postoperative pulmonary complications (PPCs) in liver transplant recipients and to construct Nomogram model to identify high-risk patients. Methods The clinical data of 189 recipients who underwent liver transplantation at the General Hospital of Eastern Theater Command from November 1, 2019 to November 1, 2022 were retrospective collected, and divided into PPCs group (n=61) and non-PPCs group (n=128) based on the occurrence of PPCs. Univariate and multivariate logistic regression analyses were used to determine the risk factors for PPCs, and the predictive effect of the Nomogram model was evaluated by receiver operator characteristic curve (ROC) and calibration curve. Results Sixty-one of 189 liver transplant patients developed PPCs, with an incidence of 32.28%. Univariate analysis results showed that PPCs were significantly associated with age, smoking, Child-Pugh score, combined chronic obstructive pulmonary disease (COPD), combined diabetes mellitus, prognostic nutritional index (PNI), time to surgery, amount of bleeding during surgery, and whether or not to diuretic intraoperatively (P<0.05). Multivariate logistic regression analysis showed that age [OR=1.092, 95%CI (1.034, 1.153), P=0.002], Child-Pugh score [OR=1.575, 95%CI (1.215, 2.041), P=0.001], combined COPD [OR=4.578, 95%CI (1.832, 11.442), P=0.001], combined diabetes mellitus [OR=2.548, 95%CI (1.024, 6.342), P=0.044], preoperative platelet count (PLT) [OR=1.076, 95%CI (1.017, 1.138), P=0.011], and operative time [OR=1.061, 95%CI (1.012, 1.113), P=0.014] were independent risk factors for PPCs. The prediction model for PPCs which constructed by using the above six independent risk factors in Nomogram had an area under the ROC curve of 0.806. Hosmer and Lemeshow goodness of fit test (P=0.129), calibration curve, and decision curve analysis showed good agreement with Nomogram model. Conclusion The Nomogram model constructed based on age, Child-Pugh score, combined COPD, combined diabetes mellitus, preoperative PLT, and time of surgery can better identify patients at high risk of developing PPCs after liver transplantation.

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  • Influential Factors for Graft Patency after Coronary Artery Bypass Grafting

    Abstract: Objective To evaluate graft patency at one year after coronary artery bypass grafting (CABG) and analyze the risk factors of graft occlusion. Methods We prospectively included 71 consecutive patients with coronary heart disease who underwent CABG in First Affiliated Hospital of Harbin Medical University from June to December 2010. There were 37 males and 34 females with their average age of 59.8±7.7 years. All the patients underwent CABG performed by the same surgeon, and received standard drug therapy after surgery. At 1 year after CABG, 256-slice multislice computed tomography (MSCT) angiography was performed to evaluate graft patency. All the patients were divided into two groups according to their graft patency during follow-up, including 16 patients in the occluded graft group and 55 patients in patent graft group. Preoperative, intra-operative and postoperative variables were collected. Univiariate analysis and logistic regress analysis were performed to analyze risk factors of graft occlusion. Results The graft patency was 91.0% (172/189) at 1 year after CABG. Univiariate analysis showed that pre-operative cholesterol (t=-2.389,P=0.017), diffused coronary artery disease (χ2=4.449,P=0.042), diameter of target vessels (t=5.064,P=0.000), non-adherence to prescribed antiplatelet medications (χ2=10.175,P=0.008) were potential risk factors of graft occlusion after CABG. Logistic regress analysis showed that diameter of target vessels [RR=0.014,95% CI (0.001,0.229),P=0.003] and non-adherence to prescribed antiplatelet medications [RR=13.375,95% CI (1.075,175.536),P=0.044] were significant risk factors for graft occlusion. Conclusion The graft patency is satisfactory at 1 year after CABG. Graft patency after CABG is closely related to the stenosis degree of target vessels and adherence to prescribed antiplatelet medications after surgery.

    Release date:2016-08-30 05:51 Export PDF Favorites Scan
  • ARTICULAR EXTERNAL FIXATION FOR CHRONIC DORSAL INSTABILITY OF DISTAL RADIOULNAR JOINT

    ObjectiveTo discuss the clinical result of extrinsic radioulnar tether combined with anchoring nail fixation for treating chronic dorsal instability of the distal radioulnar joint (DRUJ). MethodsBetween July 2011 and December 2012, 6 patients with chronic dorsal instability of the DRUJ were treated with extrinsic radioulnar tether combined with anchoring nail fixation. There were 1 male and 5 females with the average age of 27.3 years (range, 22-35 years). All of 6 patients had a wrist trauma history. The average disease duration was 4.8 years (range, 6 months to 15 years). Radiographs were taken postoperatively to observe the anchoring nail loosening. The stress test and forearm rotation test were used to evaluate the function of DRUJ. The complications, the grip power, range of motion, and visual analogue scale (VAS) scores were recorded at last follow-up. And the joint function was evaluated by disability of arm, shoulder, and hand (DASH) score. ResultsPrimary healing of incision was obtained in all cases, without any complications such as infection and ulnar neck fracture. All 6 patients were followed up 6-24 months (mean, 13.7 months). Stability was achieved in all patients. Radiographs showed that the joint space was widened and dislocation of the ulnar head was improved at 3 and 6 months after operation. The results of the stress test and forearm rotation test were negative. At last follow-up, the grip power, DASH score, VAS score, and range of motion of the wrist were significantly improved when compared with preoperative ones (P<0.05). ConclusionExtrinsic radioulnar tether combined with anchoring nail fixation is an easy method of surgical revision to treat chronic dorsal instability of DRUJ, which can maintain the stability and protect the blood supply of triangular fibrocartilage complex.

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  • Repair of thumb defects with modified radial dorsal fasciocutaneous flap of thumb

    ObjectiveTo investigate the operative method of repairing soft tissue defect of the thumb with modified radial dorsal fasciocutaneous flap and its effectiveness.MethodsBetween June 2015 and December 2016, 15 patients with volar or dorsal defects of the thumb were treated with modified radial dorsal fasciocutaneous flaps which distal pedicles were cut off. Of 15 cases, 11 were male and 4 were female, aged 35-70 years (mean, 46 years). The causes of injury included crush injury in 12 cases and avulsion injury in 3 cases. Because all patients had volar or dorsal defects of the thumb which were accompanied by tendon or bone exposure, they had no condition or desire to replant. There were 12 cases of volar defect of thumb and 3 cases of dorsal defect. The area of defects ranged from 2.0 cm×1.2 cm to 3.0 cm×2.5 cm. The time between injury and operation was 16 hours to 2 days (mean, 30.4 hours). The radial dorsal fascio-cutaneous flaps of 2.3 cm×1.5 cm to 3.3 cm×2.8 cm in size were adopted to repair defects. The donor sites were directly sutured.ResultsAll flaps survived, and no severe swelling or tension blister occurred. The donor sites and wounds healed by first intention. All patients were followed up 3-12 months (mean, 6 months). The color and texture of the grafted flaps were similar to those of normal skin, with no bloated appearance. According to total active motion standard at last follow-up, the finger function was excellent in 8 cases and good in 7 cases.ConclusionModified radial dorsal fasciocutaneous flap of the thumb is a reliable flap with easy dissection and less trauma in repair of soft tissue defects of the thumbs, and satisfactory clinical outcome can be obtained.

    Release date:2017-07-13 11:11 Export PDF Favorites Scan
  • Clinical analysis of adverse drug reactions related to coronavirus disease 2019

    Objective To analyze the clinical characteristics of adverse drug reaction (ADR) caused by 3 kinds of coronavirus disease 2019 drugs, and provide a reference for clinical safe medication. MethodsA total of 33 patients with coronavirus disease 2019 admitted to Xiangtan Central Hospital from January 20 to March 5, 2020 were selected as the research objects. The clinical data of patients with ADR during the antiviral process were analyzed retrospectively. The patients’ gender, age, type of medication, combination medication, organs or systems involved, and clinical manifestations were summarized and analyzed. Results A total of 33 patients were enrolled. A total of 21 cases of ADR were reported. The incidence of ADR is higher in patients older than 60 years (80.0%). The most common clinical manifestations are digestive tract symptoms (66.7%). The incidence of ADR is highest in the combination of lopinavir/ritonavir+arbidol+ribavirin (100.0%), followed by the combination of lopinavir/ritonavir+arbidol (85.7%). Abidol and ribavirin each caused 1 case of severe ADR. Conclusion For patients with coronavirus disease 2019, the combination of two or more antiviral drugs should be avoided, and pharmaceutical monitoring should be strengthened for elderly, severe/critical and allergic patients.

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