west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "徐翔" 3 results
  • Effect of DC-CIK Cells' Biotherapy in Comprehensive Therapy of Esophagus Cancer: A Randomized Controlled Trial

    ObjectiveTo investigate the short-term curative efficacy of DC-CIK in comprehensive therapy of esophagus cancer. MethodsWe randomly allocated 52 patients with esophagus cancer who had preoperatively confirmed by CT on stage Ⅱ-Ⅲ B into an observation group and a control group with 26 patients in each group. There were 14 male and 12 female patients in the observation group at median age of 60 years (range:49-67 years). There were 16 male and 10 female patients in the control group with median age of 62 years (range:48-65 years).The control group received postoperative chemotherapy, and the observation group received postoperative chemotherapy combined with DC-CIK biotherapy. The combination of paclitaxel and cisplatin for four cycles was choosen as the chemotherapy regimen. Patients in the observation group were treated with DC-CIK biotherapy for 2 weeks after operation. At the fifth week they received the first cycle of chemotherapy. There was a course of biotherapy between two cycles of chemotherapy. The clinical efficacy, lymphocyte subtypes, and intracellular cytokines in peripheral blood of the patients, performance status (KPS) and adverse reactions were compared. ResultsAll patients completed the therapy regimen successfully. In the observation group, the ratios of CD3+, CD4+, CD4+/CD8+, CD56+, and CD19+ increased, and the ratio of CD8+ decreased with significant differences (P<0.05).The biotherapy significantly increased interleukin 2 (IL-2), IL-12, interferon gamma (IFN-γ) and tumor necrosis fator (TNF)-α level (P<0.05). However, in the control group, there was no significant difference between post and pre-therapy in the levels of lymphocytes and cytokines. The effective rate of KPS was 76.92% in the observation group and 46.15% in the control group with a significant difference (P=0.023). No other adverse reactions except 3 patients with fever in the observation group were found. ConclusionThe short-term curative efficacy of DC-CIK in comprehensive therapy of esophagus cancer is distinct. DC-CIK biotherapy can improve patients' immune functions and elevate their life quality, so it is likely to be an effective adoptive immunotherapy for esophagus cancer.

    Release date:2016-10-02 04:56 Export PDF Favorites Scan
  • Analysis, Prevention and Treatment of Complications of 165 Patients with Thoracoscopic Esophagectomy

    Objective To evaluate the characteristics and reasons of complications in the patients with thoracoscopic esophagectomy. Methods We retrospectively analyzed the clinical data of 165 patients with thoracoscopic esophagectomy in our hospital from January 2013 through January 2015. There were 102 males and 63 females at average age of 67.9±8.3 years. Results The operation time was 275.3±50.2 min. The intraoperative blood loss was 230.0±110.5 ml. The number of lymph node dissection was 18.1±6.5. The volume of drainage in thoracic cavity was 750±550 ml on the third day after operation. Thoracoscopic esophagectomy surgeries were successful except that 13 patients (7.8%) converted to open operation including 6 patients (4.2%) with severe pleural adhesion, 2 patients (1.2%) with hemorrhage, 2 patients (1.2%) with arrhythmia, and 3 patients (1.8%) with abnormal oxygenation. There were 17 patients (10.8%) were with intraoperative complications including 2 patients (1.2%) with arrhythmia, 3 patients (1.8%) with abnormal oxygenation, 7 patients (4.2%) with hemorrhage caused by vascular injury, 4 patients (2.4%) with thoracic duct injury, 1 patient (0.6%) with recurrent laryngeal nerve injury. Moreover, 46 patients (27.8%) experienced postoperative complications including 23 patients (13.9%) with pulmonary infection, 6 patients (3.6%) with hoarseness, 4 patients (2.4%) with anastomotic leakage, 3 patients (1.8%) with incision infection, 2 patients (1.2%) with tracheoesophageal fistula, and 2 patients (1.2%) with pneumothorax. Unexpectedly, five patients underwent re-operation due to chylothorax (n=3, 1.8%) and hemorrhage (n=2, 1.2%). One patient (0.06%) died of acute pulmonary embolism. Conclusion Serious adhesion in abdominal cavity, abnormal of lung and heart. And bleeding are the main reasons caused transferring open thoracic surgery operation in patients with thoracoscopic esophagectomy. Lung infection, hoarseness, and anastomotic leakage of neck are the most common postoperative complications. And acute pulmonary embolism is the main cause of postoperative death. Proper precautions to decrease the morbidity of complication are necessary.

    Release date: Export PDF Favorites Scan
  • 纳米炭染色结直肠癌淋巴结分站对比研究

    目的探究纳米炭染色对结直肠癌淋巴结示踪的规律以及对转移淋巴结检出的影响。方法回顾性收集2022年4月至2023年9月期间于重庆医科大学附属第一医院胃肠外科接受腹腔镜结直肠癌根治性手术及术前行肿瘤纳米炭标记的92例患者的标本。新鲜标本淋巴结按第一站、第二站及第三站分检,各站又分为染色组和未染色组。比较各组间及组内不同站不同染色程度淋巴结的差异。结果共纳入92例患者,共分检出淋巴结2 859枚,其中转移淋巴结66枚(2.3%),未转移2 793枚(97.7%);黑染淋巴结2 167枚(75.8%),未染色692枚(24.2%)。淋巴结染色率从第一到第三站逐渐递增(P<0.017);第一站和第二站转移淋巴结的染色率比同站所有淋巴结染色率低(χ2=23.959,P<0.001;χ2=7.187,P=0.007),但在第三站中差异无统计学意义(χ2=1.155,P=0.283);第一站和第二站染色淋巴结转移率小于未染色淋巴结(χ2=26.224,P<0.001;χ2=7.520,P=0.006),但第三站中差异无统计学意义(χ2=1.232,P=0.267)。结论纳米炭淋巴结示踪效果随着淋巴回流逐渐增强。在第一站和第二站,其对于转移淋巴结的显示缺乏特异性,手术及分检过程中应更关注未染色淋巴结。在第三站淋巴结中,能够更有效地示踪转移淋巴结,可按染色淋巴结进行针对性地淋巴结清扫。

    Release date: Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content