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find Author "成传访" 2 results
  • 癫痫遗传学分析的临床教学实践探讨

    癫痫是一种由多种原因引起的慢性神经系统疾病,遗传因素在癫痫中的作用日益显著。随着精准医学的快速发展,目前已发现近3 000个基因与癫痫相关,癫痫的遗传学分析在临床诊断和个体化精准治疗中亦日益受到重视,因此提高癫痫专科医生遗传学理论知识、基因变异解读技能以及精准诊疗水平势在必行。本文旨在探讨如何在临床教学实践中进行癫痫遗传学分析教学,我们采取多模式教学方法,包括遗传学理论知识学习、基于案例的学习(case-based learning,CBL)示范教学、一对一教学、病例实操教学、小组讨论教学及临床见习教学,以培养适应精准医学快速发展的高素质创新型医学人才。

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  • Correlation between Serum Bilirubin and Recurrent Coronary Events in Patients after Coronary Artery Stent Implantation

    ObjectiveTo investigate the factors related to recurrent coronary events in patients after coronary artery stent implantation. MethodsWe retrospectively studied the patients performing coronary angiography (CAG) who were admitted to the Department of Cardiology of the Second Affiliated Hospital of Guangzhou Medical University between January 2012 and June 2013. All of the enrolled patients had received CAG in our hospital, with complete coronary angiogram and clinical data. The patients were divided into two groups according to the coronary angiogram and clinical data: coronary event group and non-coronary event group. SPSS 16.0 software was employed for statistical analysis, and multivariate analysis was performed using binary logistic regression model to analyze the risk factors. ResultsA total of 115 patients were included, of which 50 patients had recurrent coronary events. Both the serum total bilirubin and unconjugated bilirubin in patients with coronary events were significantly lower compared with the patients without coronary events at baseline and at the time of CAG reexamination (P < 0.05 or P < 0.01). The serum total bilirubin at baseline and the serum total bilirubin and unconjugated bilirubin at the time of CAG reexamination were significantly lower in patients with revasculization due to the progression of coronary artery lesions compared with the patients without coronary events (P < 0.05 or P < 0.01). The serum unconjugated bilirubin in patients with in-stent restenosis were significantly lower compared with the patients without coronary events at baseline and at the time of CAG reexamination (P < 0.05). The results of logistic regression analysis showed that multi-vessel coronary artery disease (two-vessel coronary artery disease: OR=10.094, 95%CI 2.498 to 40.798, P=0.001; three-vessel coronary artery disease: OR=16.047, 95%CI 4.121 to 62.481, P=0.000) and low serum unconjugated bilirubin (OR=0.873, 95%CI 0.773 to 0.987, P=0.03) were independent risk factors of recurrent coronary events. ConclusionMulti-vessel coronary artery disease and low serum unconjugated bilirubin are independent risk factors of recurrent coronary events in patients after coronary artery stent implantation.

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