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find Keyword "放射性肺损伤" 3 results
  • Influencing Factors for Acute Radiation Pneumonitis in Non-operative Esophageal Cancer after Radiotherapy

    ObjectiveTo analyze the clinical and dosimetric impacts on radiation pneumonitis (RP), and provides data for radiotherapy planning. MethodsWe reviewed 59 non-operative esophageal cancer patients who underwent radiotherapy from October 2010 to November 2012 to identify the correlation between the clinical and dosimetric parameters with acute radiation pneumonitis (ARP) and severe acute radiation pneumonitis (SARP) by t-Test, Chi-Square Test and logistic regression analysis. ResultsAmong the 59 patients, 33 (55.9%) developed ARP, in whom 9 (15.3%) developed SARP. Univariate analysis showed that lung infection during radiotherapy, mean lung dose (MLD), and dosimetric parameters are significantly correlated with RP. Multivariate analysis revealed lung infection during radiotherapy, MLD≥13 Gy, and V30≥13% were significantly correlated with the increasing risk RP. ConclusionLung infection during radiotherapy, MLD, and V30 are the influencing factors of RP, which should be seriously considered when formulating radiotherapy plan to avoid RP.

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  • Therapeutic Effect on Radioative Lung Injury by Different Doses of Tanshinone ⅡA Microemulsion

    ObjectiveTo investigate the therapeutic effects of different doses of tanshinone ⅡA microemulsion on radioactive lung injury. MethodsSeventy-two Wistar rats were randomly divided into a healthy control group,a model group,a liposome microemulsion treatment group,a tanshinone ⅡA microemulsion high-dose group,a tanshinone ⅡA microemulsion middle-dose group,and a tanshinone ⅡA microemulsion low-dose group.Radiation-induced lung injury model was established by irradiation of radiotherapy instrument.In addition to the control group,other groups received 6MV X radiation with one dosage of 22Gy.Four rats in each group were sacrificed on 7th,14th,and 28th day,respectively.Lung tissues were sampled to analyze the pathological changes by HE staining and the Smad7 mRNA expression by RT-PCR.The level of glutathione(GSH)in peripheral blood was determined by ultraviolet spectrophotometric method. ResultsIn the model group and four treatment groups,lung tissue biopsy showed the pathological changes gradually from pulmonary alveolitis to fibrosis.The level of Smad7 mRNA in lung tissue and GSH in peripheral blood were higher in the high-dose group,the middle-dose group and the low-dose group than those in the model group at all time points(P<0.05),and were highest in the high-dose group.There was no significant differences in the level of Smad7 mRNA in lung tissue and GSH in peripheral blood between the liposome microemulsion treatment group and the middle-dose group. ConclusionTanshinone ⅡA microemulsion has treatment effect on lung injury in a dose dependent manner.

    Release date:2016-10-12 10:17 Export PDF Favorites Scan
  • 尼达尼布治疗放射性肺损伤一例并文献复习

    目的探讨放射性肺损伤的发病机制、临床表现、影像学特点、可能的治疗手段及预后。方法分析 1 例确诊为肺鳞癌合并放射性肺损伤并接受尼达尼布治疗患者的临床资料,结合相关文献复习,总结其临床特点、治疗过程及预后。结果本例为 72 岁男性肺鳞癌患者,经同步放化疗和放射性粒子植入术后并发放射性肺损伤,主要症状为活动后气促,胸部 CT 表现为双肺磨玻璃影和网格影,右下肺显著。经尼达尼布规范化治疗 4 个月后,临床症状以及影像学都明显缓解,随访 1 年,病情持续稳定,未见明显不良反应。文献复习发现,放射性肺损伤患者临床上多表现为干咳、发热及呼吸困难,重症患者可危及生命,影像学多表现为放射靶区的片状影,多以肺实变伴支气管充气征为主。最常用的治疗药物为糖皮质激素,也有少部分患者对激素治疗反应不佳,新的治疗手段仍在探索之中。结论放射性肺损伤是恶性肿瘤患者放疗过程中较常见的并发症,但目前治疗手段有限,尼达尼布作为一种新型的小分子靶向药,可能对放射性肺损伤具有一定的修复作用。

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