ObjectiveTo analyze the clinical and dosimetric impacts on radiation pneumonitis (RP), and provides data for radiotherapy planning. MethodsWe reviewed 59 non-operative esophageal cancer patients who underwent radiotherapy from October 2010 to November 2012 to identify the correlation between the clinical and dosimetric parameters with acute radiation pneumonitis (ARP) and severe acute radiation pneumonitis (SARP) by t-Test, Chi-Square Test and logistic regression analysis. ResultsAmong the 59 patients, 33 (55.9%) developed ARP, in whom 9 (15.3%) developed SARP. Univariate analysis showed that lung infection during radiotherapy, mean lung dose (MLD), and dosimetric parameters are significantly correlated with RP. Multivariate analysis revealed lung infection during radiotherapy, MLD≥13 Gy, and V30≥13% were significantly correlated with the increasing risk RP. ConclusionLung infection during radiotherapy, MLD, and V30 are the influencing factors of RP, which should be seriously considered when formulating radiotherapy plan to avoid RP.
ObjectiveTo investigate the therapeutic effects of different doses of tanshinone ⅡA microemulsion on radioactive lung injury. MethodsSeventy-two Wistar rats were randomly divided into a healthy control group,a model group,a liposome microemulsion treatment group,a tanshinone ⅡA microemulsion high-dose group,a tanshinone ⅡA microemulsion middle-dose group,and a tanshinone ⅡA microemulsion low-dose group.Radiation-induced lung injury model was established by irradiation of radiotherapy instrument.In addition to the control group,other groups received 6MV X radiation with one dosage of 22Gy.Four rats in each group were sacrificed on 7th,14th,and 28th day,respectively.Lung tissues were sampled to analyze the pathological changes by HE staining and the Smad7 mRNA expression by RT-PCR.The level of glutathione(GSH)in peripheral blood was determined by ultraviolet spectrophotometric method. ResultsIn the model group and four treatment groups,lung tissue biopsy showed the pathological changes gradually from pulmonary alveolitis to fibrosis.The level of Smad7 mRNA in lung tissue and GSH in peripheral blood were higher in the high-dose group,the middle-dose group and the low-dose group than those in the model group at all time points(P<0.05),and were highest in the high-dose group.There was no significant differences in the level of Smad7 mRNA in lung tissue and GSH in peripheral blood between the liposome microemulsion treatment group and the middle-dose group. ConclusionTanshinone ⅡA microemulsion has treatment effect on lung injury in a dose dependent manner.