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find Author "文倩" 2 results
  • 水凝胶冰敷贴辅助治疗经桡动脉穿刺行冠状动脉造影术后患者的临床应用

    目的探讨水凝胶冰敷贴辅助治疗缓解经桡动脉穿刺行冠状动脉造影术后患者肢体肿胀及疼痛的疗效。 方法2013年6月-2014年10月将540例经桡动脉穿刺行冠状动脉造影术后的患者采用简单随机化分组的方法分为对照组、试验1组和试验2组,每组180例。3组患者术后均使用压迫止血器压迫止血。对照组:单纯压迫止血;试验1组:除单纯压迫止血外,立即使用水凝胶冰敷贴外敷穿刺侧腕部;试验2组:压迫止血后穿刺侧腕部及手掌发生肿胀时,再使用水凝胶冰敷贴。观察止血过程中,3组患者肢体疼痛、肿胀程度及消退情况。 结果3组术前和术后6 h血氧饱和度无明显差异,患者末梢循环良好。对照组、试验1组、试验2组术前与术后穿刺侧掌围差值分别为(3.50±0.12)、(1.80±0.23)、(1.60±0.40)cm,试验1组与试验2组均较对照组减少,差异有统计学意义(P<0.05),试验2组与试验1组差异无统计学意义(P>0.05)。对照组、试验1组、试验2组术后1 h穿刺疼痛评分分别为(3.22±0.52)、(2.13±0.35)、(2.62±0.56)分,术后6 h穿刺疼痛评分分别为(4.51±0.38)、(2.31±0.41)、(2.45±0.26)分,试验1组与试验2组术后1 h和6 h评分均低于对照组,差异有统计学意义(P<0.05);试验2组与试验1组比较,术后1 h疼痛评分差异有统计学意义(P<0.05),术后6 h疼痛评分差异无统计学意义(P>0.05)。 结论水凝胶冰敷贴能减轻患者行冠状动脉造影术后因压迫止血导致的肢体肿胀程度及疼痛程度,有明显的辅助治疗作用。

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
  • Research progress of CXC chemokine ligand 12-CXC chemokine receptor 4 / atypical chemokine receptor 3 axis on the mechanism of coronary heart disease

    CXC chemokine ligand 12 (CXCL12) is a kind of small molecular polypeptide substance that can move cells towards specific parts. It is widely distributed in heart, skeletal muscle, liver, brain and so on. Current studies believe that CXCL12 plays a role in the formation and progression of cardiovascular diseases by binding to CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3), but the mechanism is not very clear, and even some contrary experimental results appear. This review mainly discusses the role of CXCL12-CXCR4/ACKR3 axis in atherosclerosis, myocardial infarction, and myocardial remodeling, in order to explore the inflammatory mechanism in the development of coronary heart disease and provide a basis for further research of clinical drugs.

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