Objective To evaluate the trends, dominant diseases and clinical outcomes of the global interventional therapy for tumors based on evidence, so as to provide references for standard access of interventional technology. Methods Such databases as PubMed, EMbase, Web of Science, The Cochrane Library, CBM, CNKI and VIP were electronically and comprehensively searched for relevant clinical or fundamental studies about interventional therapy for tumors from inception to September, 2012. Two reviewers independently screened literature according to the inclusion and exclusion criteria and extracted data. Then, descriptive analysis was performed using SPSS 13.0 and Microsoft Excel 2003 software. Results Totally, 4 544 studies were included, consisting of 4 136 (91.0%) clinical studies and 408 (9.0%) fundamental studies. These clinical studies including 155 systematic reviews (SRs), 338 randomized controlled trials (RCTs), 1 191 clinical controlled trials (CCTs), and 2 451 case series or case reports (CSs/CRs). Transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) were the most clinically frequenly-used interventional technologies for tumors, accounting for 32.6% and 17.1% of the total, respectively. Hepatocellular carcinoma (HCC) was the dominant tumor, which was mentioned in 99 SRs (57.6%), 198 RCTs (58.6%), 824 CCTs (69.1%) and 1 191 CSs/CRs (48.6%), following by colorectal liver metastases (CLM). Radiofrequency ablation (RFA) treating HCC resulted in a higher rate of 3-year survival (12 SRs/Meta-analyses) and lower recurrence (10 SRs/Meta-analyses) compared with percutaneous ethanol injection (PEI). Compared with hepatic resection (HR), RFA treating HCC resulted in lower rates of 3-year (11 SRs/Meta-analyses) and 5-year survival (9 SRs/Meta-analyses), and no significant difference was found in 1-year survival between the two groups (17 SRs/Meta-analyses). Preoperative TACE before HR or liver transplantation could not improve the survival for patients with advanced HCC (6 SRs/Meta-analyses), but postoperative TACE might prolong the 1-and 3-year survival (3 SRs/Meta-analyses). TACE combined with other interventional therapy (i.e., RFA, PEI) could also prolong the survival of HCC patients. For the treatment of uterine leiomyoma, uterine artery embolization (UAE) resulted in less hospital duration or operative time, and it caused a higher re-intervention rate, compared with surgery, but it lacked long-term outcomes. Conclusion Interventional therapy is an optional and promising technology for patients with tumors. We should well-consider currently available best clinical evidence as well as local medical facilities or skill level when applying them to clinical practice, so as to perform relevant interventional techniques with scientific, rational and standardized methods.
Objective To investigate the hot topics of research on evidence-based medicine in 2002. Method To search MEDLINE for papers on evidence-based medicine published in 2002, identify high-frequency subject headings related to research on evidence-based medicine, and cluster the high-frequency subject headings according to rates they appeared in common papers. Results 545 papers, 1 554 subject headings, 30 high-frequency subject headings on evidence-based medicine, and nine clustering categories of high-frequency subject headings were identified through search. Conclusions Both high-frequency subject headings and their clustering categories suggested that “evidence-based practice guidelines and their innovation”, “evidence-based health research and health policy”, “methodology on systematic reviews and randomized clinical trials”, “method of evidence-based decision making and its application in various subjects”, were the hot topics of evidence-based medicine. They provided useful references for Chinese medical professionals to practice evidence-based medicine.
Objective To reveal the worldwide research status and hot topics of sleep apnea syndrome ( SAS) . Methods Articles were searched from Web of Science ( SCI) , Essential Science Indicator ( 2000 to 2010) database using sleep apnea syndrome or apnea as keywords. Retrieved documents were analyzed using the database with its own statistical functions and histcite software ( version 8.12. 16) .Results Since 1992 the international scientific papers on the SAS study showed a gradual upward trend.The United States is a world leader in this field. Recent research has focused on vascular endothelial barrier function and repair, oxidative stress, inflammation, cognitive function, special populations such as the elderlyor children patients with SAS. Conclusion Clinical researchers have paid more attention to SAS than before, but there are still many important issues unresolved.
OBJECTIVE: To comprehend the progress of tissue engineering research and speculate its developmental trends. METHODS: MEDLINE search was conducted to retrieve the papers published between 1987 to 1999 under the main headings of tissue engineering. Years, nationalities, languages, journals, authors and heading frequencies of 314 papers were analyzed by bibliometrics. RESULTS: Since 1990, the number of tissue engineering research literatures had doubled, and papers between 1998 and 1999 made up 57.96% of the total papers. All papers came from 15 nations, in 6 languages and 140 journals; 64.97% came from United States and 25.79% from England, Netherlands and Germany; 93.95% was in English; 42.04% was published on 15 journals. Vacanti JP and 19 other authors presented 5 to 24 papers. Heading frequencies were cytology 22.89%, transplantation 13.30%, scaffolds and extracellular matrixes 11.72%, implanting 10.60%, polymers 8.91%, potential applications 8.91%, artificial substitutes 6.88%, tissue culture 6.70% and biogenetics 4.96%. CONCLUSION: Tissue engineering literatures mainly come from United States, England, Netherlands and Germany. English is the major language. J Biomed Mater Res and 14 other journals are important journals about tissue engineering research. Vacanti JP and 19 other authors are prolific authors. Cytology, transplantation, scaffolds and extracellular matrixes and implanting are hot topics and key points on tissue engineering research.
Objective To learn the hotspots of study in ischemic optic neuropathy (ION). Methods Literature on ION published in January 2000 to July 2012 was identified in Pubmed database. MeSH terms that frequently appeared were identified and co-word analysis was carried out by cluster analysis. Then a network was drawn using social network analysis. Results A total of 1045 papers were included. The United States, England, Germany, France and Netherlands together accounted for 71.53% (748) of the articles. There were 28 high-frequency MeSH terms and hot topics clustered into four fields. The appearance frequency of MeSH showed that most research focused on: (1)postoperative or arteritic ION; (2)epidemiology, pathology and diagnosis of ION; (3)pathophysiology and therapy of ION; (4) chemically induced ION. Conclusion The international main research focus of ION includes four fields, which may provide reference or scholars both in scientific research and clinical research.
Objective To analyze and reveal the domestic and abroad studies on polypoidal choroidal vasculopathy (PCV) by bibliometric. Methods Foreign articles were searched from American Institute of Scientific Information online database of web of science (WOS) database, Chinese articles were searched from China National Knowledge Infrastructure (CNKI) database. The age distribution, national and regional, funding agency and citation of the PCV literatures published before December 31 2012 were analyzed by software Bibexcel and SPSS 17.0. Results Totally 696 literatures were analyzed, including 440 foreign literatures and 256 Chinese literatures. The numbers of foreign literatures were gradually increased since 2000, significantly after 2007, reached the maximum at 2011. The literatures were mainly in English, the number of the literatures of China ranked 4th of all countries. The National Natural Science Foundation of China ranked No.5 of funding agency. Citations gradually increased since 2000, increased significantly after 2008; there were 30 highfrequency subjects, and hot topics were clustered into 5 categories: treatment of PCV, genetics studies of PCV, detection, diagnosis and epidemiology of PCV, relationships between PCV and macular degeneration, related cytokine of PCV. Chinese literatures increased since 2000, significantly after 2006, and reached the maximum at 2010; there were 15 literatures supported by National Natural Science Foundation of China; Citation of Chinese literatures gradually increased since 2001, and reached the maximum at 2012. There were 30 highfrequency subjects, and hot topics were clustered into 5 categories: genetics and cytokine studies of PCV, detection and diagnosis of PCV, treatment of PCV, PCV and macular diseases, PCV and vitreous hemorrhage. Conclusions Literatures of PCV were gradually increased since 2000, abroad and domestic literatures of PCV reached maximum at 2011 and 2010 respectively. The abroad research of PCV focuses on 5 categories: treatment of PCV, genetics studies of PCV, detection, diagnosis and epidemiology of PCV, relationships between PCV and macular degeneration, related cytokine of PCV. The domestic research focuses on genetics and cytokine studies of PCV, detection and diagnosis of PCV, treatment of PCV, PCV and macular diseases, PCV and vitreous hemorrhage.
Objective To learn the bibliometric characteristics of Chinese ophthalmological papers indexed in SCI database from 2007 to 2011.Methods All the ophthalmological papers published in the source journals indexed in the SCI database from 2007 to 2011 were retrieved. The papers of first authors were manually selected for bibliometric analysis.Results The ophthalmological papers published by Chinese scholars as the first author were 478, 482, 698, 791, and 1049 from 2007 to 2011 (total 3498). The five institutions that published papers in the most were Sun Yat-sen University, Capital University of Medical Sciences, Fudan University, Hong Kong Chinese University and Shanghai Jiaotong University. The papers were distributed in 625 journals. The top five journals the papers were published in were Molecular Vision (332), International Journal of Ophthalmology (268), Investigative Ophthalmology amp; Visual Science (206), Chinese Medical Journal (109), and Graefeprime;s Archive for Clinical and Experimental Ophthalmology (104). The 3498 papers were cited 12 030 times, 3.44 times per paper. The rate of non-cited articles for 5 year,3 year and 2 year periods were 12.55%, 24.21% and 38.43% respectively. Conclusions Chinese ophthalmological papers indexed in SCI database have gradually increased. Chinese ophthalmological papers mainly originate in the affiliated hospital of universities and colleges. There are four ophthalmologic professional periodicals included in the top five in the quantity of articles.
Objective To analyze the international hotspots of study in age-related macular degeneration (AMD) in recent years. Methods Articles related to AMD that appeared during period January 2002-December 2010 from Pubmed database were quantitatively analyzed by software of BICOMS. PASW 18.0 statistical software used to cluster high frequency keywords of published articles. Clustering relationships of high frequency hot topics were identified. Results A total of 8529 AMD related articles were retrieved. The number of published articles in 2009 was 2.45 times greater than that of published articles in 2002. Six thousand five hundred and fourteen AMD related articles were published in the United States, England and Germany, which accounted for 76.37% of worldwide total. Fifty-two high frequency keywords were analyzed. They were clustered into 6 categories, which were identified as physiological/genetics, etiology and prevention and control, pathology and tomography and other diagnostic techniques, surgical therapy, drug therapy and photochemical therapy, and drug/laser therapy. Conclusions Recently, more attention has been paid to AMD, and the published AMD related articles has rapidly increased. The United States and European countries occupy the dominant position for the number of published AMD related articles. The international main research focus included 6 fields: basic research in AMD, etiology, pathology and diagnostic techniques, AMD prevention and control, surgery/drugs/laser and photochemical treatment of AMD.
Objective To investigate how many hospitals can perform vitrectomy and its relationship to economic development in China.Methods Bibliometric data of retina-vitreous literatures were searched from the China National Knowledge Infrastructure (CNKI) academic databases. We used pars plana vitrectomy (PPV) as a keyword and defined address as mainland China, limited years to 1993 -2009. From those data we analyzed which hospital performed PPV. We also communicated with some hospitals by phone, email to confirm if they were performing PPV. Gross domestic product (GDP), population data and economic development ranking were extracted from the China Statistical Yearbook 2009 (National Bureau of Statistics of China). PPV carry-out rate, PPV-hospital shares and their relationships with the GDP in each regional municipality were analyzed.Results All together this study retrieved 4632 articles meet our requirements. There were 340 hospitals carrying out PPV in mainland China, located in 22 provinces, five autonomous regions and four metropolitan municipalities. The top five provinces with higher PPV carryout rate were Shandong (93,75%), Zhejiang (90,00%), Hebei province (90.00%), Jiangsu (83.33%) and Guangdong (75.00%). There was significant difference in per capita share of PPVhospitals between different cities (chi;2=181,153，P=0,000) and in the PPV carry-out rate between different cities (chi;2=749.217，P=0.000). There were 210 private eye hospitals in China,62 hospitals (18.23%) of them could perform PPV included 39 hospitals located in regionallevel cities. The coefficient correlation between PPV and GDP of different provinces was 0.842 (P=0.000). Conclusions Vitrectomy is widely performed in mainland China, but geographical distribution of PPV-performing hospitals is uneven. PPV performance is closely related with regional economic development,and private hospitals play certain roles in promoting the application of vitrectomy.