目的观察盐酸沙格雷酯治疗血栓闭塞性脉管炎的近期疗效。 方法回顾性分析笔者所在医院2009年7月至2012年7月期间采用盐酸沙格雷酯治疗的28例血栓闭塞性脉管炎患者的临床资料，比较服药前后患者间歇性跛行距离、静息痛评分、冷感评分及溃疡面积的差异。 结果用药4周后，患者的无痛跛行距离〔（287±32）m比（167±28）m〕和最长跛行距离〔（315±40）m比（187±34）m〕延长，静息痛得分（1分比2分）和冷感得分（1分比2分）降低，溃疡面积缩小〔（6.18±3.28）cm2比（10.06±4.25）cm2〕，差异均具有统计学意义（P<0.05）。 结论盐酸沙格雷酯能改善血栓闭塞性脉管炎的缺血症状。
Objective To explore the clinical experience on treatment of thromboangitis obliterans (TAO) by embolectomy. Methods Fourteen of 121 patients with TAO treated in our hospital from March 2000 to March 2010 were included in this study. Total 14 limbs consisted of 2 upper extremities and 12 lower extremities. Among these cases, 8 cases underwent embolectomy and 6 cases received embolectomy combined the stem cell transplantation. Results Of 14 cases of TAO patients, 11 cases were successfully treated by surgery and 3 cases failed. After successful operation, patient’s pain disappeared and anklebrachial index improved obviously. Seven patients treated successfully by surgery were followed up from 5 months to 8.5 years (mean 4 years), in whom the intermittent claudication and rest pain disappeared in 4 cases, and disease deteriorated in 2 cases who always smoked, and one case had intermittent claudication who stopped smoking. For 3 cases patients failed to operation, one lost followup, one had to receive a below knee amputation due to keep smoking after operation, and one case who stopped smoking underwent alleviative symptoms for 3 years. Conclusion Embolectomy is a safe and effective technique for treating TAO.