The studies of immunohistochemistry, histochemisu3r and electron microscopy in 50 patients with retinoblastoma were carried out. Our results show that retinoblastoma origin from primitive retinal neuronal cells that can differentiate into nmture neuron (including retinal photoreeeptor) and glial cells.The glial component in the retinoblastoma is mainly reactive glial proliferation.There is a good prognosis in the patients with retinoblastoma in which there are a lot of differiation areas and glial proliferation. （Chin J Ocul Fundus Dis,1993,9:193-197）
Objective To study the global and histological changes of myopia and explore its pathogenic mechanism. Methods Chicks were reared with monocular suture of eyelid. When myopia had been confirmed by optometry, eyeballs were removed and subjected subsequently to measurement and light and electron microscopies. Results Three dimensions in the eyeballs of suture group were all enlarged markedly and the mean diopter was -15.00D. Under the light microscope, rod outer segment elongated and connected With PREC in suture group. With micrometer measure, cartilaginous sclera thickened and retina became thinner. Under electron microscope, rod outer segment elongated and membrane disc was intact. In the cytoplasm of RPEC, the phagosomes containing fractions of the membrane disc of outer segment were remarkably decreased. Conclusion Early form deprivation may affect the drop of membrane disc and cause eyeball enlargement; thus, myopia forms. (Chin J Ocul Fundus Dis,1999,15:20-23)