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find Keyword "曲安奈德/治疗应用" 31 results
  • 玻璃体腔注射曲安奈德联合激光光凝治疗糖尿病黄斑水肿疗效观察

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • Intravitreal triamcinolone acetonide injection combined of macular laser grid photocoagulation and macular laser grid photocoagulation only for treatment of diabetic macular edema: a meta-analysis

    Objective To evaluate the efficacy and safety of intravitreal triamcinolone acetonide combined of macular laser grid photocoagulation (IVTA/MLG) versus macular laser grid (MLG) photocoagulation only for treatment of diabetic macular edema. Methods A computerized search was conducted in the Cochrane Library, Embase Library, Pubmed, Chinese Biomedical Database, Chinese Journal Full-text Database and Chinese Science and Technology Periodicals Database. Randomized controlled trials (RCT) on IVTA/MLG and MLG only for treatment of diabetic macular edema were selected. After the data extraction, quality of RCT was assessed. The meta analysis was performed by RevMan 5.1.The outcome measures included best-corrected visual acuity (BCVA) and the central foveal thickness (CMT). Results In total, six RCT that fulfilled the eligibility criteria were included in the metaanalysis involving 166 eyes in MLG group and 165 eyes in IVTA/MLG group. The results suggested that there was no significant differences in BCVA (Z=1.27,P=0.20), but differences were statistically significant comparing CMT (Z=2.41,P=0.02), incidence of ocular hypertension and cataract (Z=3.62,P<0.01) between MLG and IVTA/MLG groups at the six month follow-up. Conclusions There is no significant advantage of IVTA/MLG as compared with MLG,but it could reduce CMT. However, a high-quality, large sample RCT should be further investigated.

    Release date:2016-09-02 05:26 Export PDF Favorites Scan
  • Using cryotherapy and intravitreal triamcinolone injection to treat Coats' disease with exudative retinal detachment

      Objective To evaluate the effects of retinal cryotherapy and intravitreal triamcinolone injection to treat Coatsprime; disease with exudative retinal detachment.Methods This was a prospective consecutive case study, and 21 patients (21 eyes) with Coatsprime; disease accompanied by exudative retinal detachment were enrolled. There were 19 males and two females patients, aged from two to 18 years. Fifteen eyes had partial retinal detachment (stage 3A) and six eyes had total retinal detachment (stage 3B). All patients underwent cryocoagulation and intravitreal triamcinolone injection. Three eyes underwent sclerotomy to drain subretinal fluid. Four eyes underwent further treatment by photocoagulation or cryotherapy for the residual abnormal blood vessels after the surgery. The follow-up ranged from three to 15 months with an average of seven months. Visual acuity, intraocular pressure, eye position and eye movements, slit lamp microscope, indirect ophthalmoscope and color fundus imaging were followed up. The last followup time was considered as the judgment time for the therapeutic effects. Results Six eyes had increased intraocular pressure after the surgery, which was controlled by local drug treatment. At the end of follow-up, 19 eyes had reattached retina, one eye had partial retinal detachment and one eye had total retinal detachment. The vision improved in three eyes,unchanged in 14 eyes, and decreased in two eyes. Other complications included strabismus (one eye) and cataract (four eyes). Conclusion The combined treatment of cryotherapy and intravitreal triamcinolone injection is an effective therapy for the Coatsprime; disease with exudative retinal detachment, as retina reattaches and visual function is saved in most patients after this treatment.

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
  • 曲安奈德玻璃体腔注射和球后注射治疗兔眼葡萄膜炎疗效对比观察

    Release date:2016-09-02 05:41 Export PDF Favorites Scan
  • 曲安奈德球周注射联合激光光凝治疗糖尿病视网膜病变黄斑水肿

    Release date:2016-09-02 05:42 Export PDF Favorites Scan
  • Intravitreal triamcinolone injection combined with or without macular grid laser photocoagulation to treat macular edema

    Objective To compare the efficacy of intravitreal triamcinolone(IVTA) injection and IVTA combined with macular laser grid photocoagulation(MLGP)to treat macular edema.Methods Consecutive 89 patients (109 eyes)diagnosed with macular edema by examinations of ocular fundus and optical coherence tomography (OCT).The visual acuity was hand moving-0.8 (0.19plusmn;0.13);the intraocular pressure(IOP)ranged from 7 mm Hg to 21 mm Hg(1 mm Hg=0.133 kPa)and the average IOP was 13.78 mm Hg.All the patients received OCT and microperimetry examinations,the central macular thickness was (570plusmn;182)mu;m;the average light sensitivity was (5.07plusmn;3.94) dB and the fixation percentage was 70.67% within 4 deg;area around the macular fovea. All the patients received IVTA treatment,39 patients(48 eyes)further received MLGP 1 month later (IVTAMLGP group). The remaining 50 patients (61 eyes) without MLGP treatment was the IVTA group. Best corrected visual acuity (BCVA),IOP,lens,OCT and microprimetry examinations before and after IVTA (1,3,6,12 months) were followed and analyzed.Results On the 12th months,the BCVA in IVTAMLGP and IVTA group was (0.41plusmn;0.20)、(0.24plusmn;0.19)respectively (P<0.05);the central macular thickness was (309plusmn;187) and (487plusmn;206) mu;m respectively(P<0.05);the mean light sensitivity of 4deg; central macular was (8.24plusmn;4.64)and(6.30plusmn;3.22)dB respectively(P<0.05);the fixation percentage was(87.01plusmn;19.70)% and(78.85plusmn;20.41)% respectively (P<0.05). During the followup recurrent macular edema was noticed in 28 eyes of IVTA group and 8 eyes of IVTAMLGP group.Conclusions IVTA combined with MLG was more effective than IVTA to cure macular edema.

    Release date:2016-09-02 05:42 Export PDF Favorites Scan
  • Photodynamic therapy combined with intravitreous injection with triamcinolone a cetonide for choroidal neovascularization

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 玻璃体内注射曲安奈德的问题与并发症

    玻璃体内注射曲安奈德(TA)一方面是利用其较强而持久的抗炎和抗新生血管作用,治疗多种与炎症过程相关的眼底疾病,主要包括多种原因所致的黄斑水肿,严重葡萄膜炎,眼内新生血管等;另一方面是利用其白色结晶的附着作用辅助玻璃体切割手术中识别玻璃体,或利用其抗炎作用硅油内注射减轻手术后炎症反应或增生性病变的发生。临床应用中也逐渐发现TA玻璃体内注射存在一些问题。首先是疗效的局限性,表现为作用不能持久,水肿易复发等;其次是药物有关的并发症,包括暂时性高眼压或继发性开角型青光眼,诱发或加重白内障,感染性或非感染性眼内炎等。眼内炎等并发症还可能误诊误治。现对玻璃体内注射TA的局限性和并发症等问题进行综述,以期对国内开展这方面工作提供借鉴。 (中华眼底病杂志,2005,21:267-270)

    Release date:2016-09-02 05:52 Export PDF Favorites Scan
  • Effect of triamcinolone acetonide on the activation and barrier function of human retinal pigment epithelium

    ObjectiveTo observe the effect of triamcinolone acetonide(TA) on activation and barrier function of human retinal pigment epithelium (RPE).MethodsARPE-19 cells were cultured in 96well tissue culture plate. Four weeks later, TA with different concentration (0.02 and 0.05 mg/ml)was added to the cells and culture for 3 or 7 days. The activation of ARPE-19 cells was assessed by methyl thiazolyl tetrazolium (MTT). ARPE-19 cells were cultured on polyester microporous filters for 4 weeks, and the transepithelial resistance (TER) was recorded. TA (0.02 and 0.05 mg/ml) was added to the culture fluid respectively, and after cultured for 1 week TER was measured again. The RPE permeability was detected by enzymelinked immunosorbent assay (ELISA) with horse radish peroxidase as the tracer. ResultsIn the culture fluid with 002 mg/ml TA cultured for 3 or 7 days, the average survival rate of ARPE-19 cells was 93.70% and 90.63% respectively, without statistic difference compared with the control (P=0.147, 0.091). While in the 0.05 mg/ml TA group after cultured for the same duration, the activation of ARPE-19 cells decreased significantly compared with the control (with the average survival rate of 87.75% and 88.98%; P=0.025, 0.043). One week after cultured with TA, TER decreased significantly while permeability improved obviously in the 2 TA groups compared to the control (Plt;0.001; 0.001lt;Plt;0.05).ConclusionTA may decrease the activation of and destroy the barrier function of ARPE-19 cells. (Chin J Ocul Fundus Dis, 2005,21:237-239)

    Release date:2016-09-02 05:52 Export PDF Favorites Scan
  • Effect of intravitreous injection with triamcinolone acetonide on retina

    ObjectiveTo investigate the effect of triamcinolone acetonide (TA) with different dosage and excipient on retina.MethodsThirty-two purebred New Zealand white rabbits randomly divided into 4 groups underwent intravitreous injection with TA. Group 1:4 mg TA without excipient; group 2:25 mg TA without excipient; group 3:4 mg TA with excipient; group 4:25 mg TA with excipient. Electroretinography (ERG) was performed on each rabbit before intravitreal injection, 1 week, 1 and 2 months after the injection. All the animals were killed and the eyeballs were extirpated 2 months after the injection, and pathological examinations including light and electron microscopy were performed.ResultsNo significant difference was found in the latent period of ERG at the points of time before and after the injection in all the groups, but the amplitudes of ERG waves was lower in groups containing excipient than that before the treatment (Plt; 0.01). The results of light and electron microscopy showed damages of tissue or structures of retina in various degrees in groups containing excipient.ConclusionIntravitreous injection of TA with the dosage of ≤25 mg without excipient does no harm to the retinal configuration and function, and excipient may lead to the change of retinal configuration and function.(Chin J Ocul Fundus Dis, 2005,21:229-232)

    Release date:2016-09-02 05:52 Export PDF Favorites Scan
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