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find Author "曾妮" 5 results
  • 准分子激光原位角膜磨镶术相关并发症的处理及预防

    【摘要】 准分子激光原位角膜磨镶术目前已成为角膜屈光手术的主流手术,其术后视力恢复较快,不适感较轻。由于手术需要用显微板层角膜刀切开掀起角膜瓣,及激光消融角膜床,因此,术中、术后可能发生一些相关的手术并发症,虽然这些并发症发生率较低,但如果处理不当,可影响患者最佳视力,现就其相关并发症的原因、处理及预防做一综述。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • Current status of intraductal papillary mucinous neoplasms of pancreas in imaging

    ObjectiveTo summarize the current status of imaging in intraductal papillary mucinous neoplasms of the pancreas (IPMN).MethodThe related literatures of imaging about IPMN of the pancreas were searched in the PubMed, CNKI, VIP, and Wanfang Data databases, etc.ResultsA variety of imaging techniques could be used to diagnosis IPMN of the pancreas, including CT, MRI, EUS, and PET-CT. The CT and MRI had great performances to diagnose and differential diagnosis of benign and malignant IPMN of the pancreas. The MRI with new targeted nanoparticle contrast agents could be used to diagnosis the early IPMN of the pancreas. The EUS was very good at detecting the wall nodules in the IPMN of the pancreas. Compared with the CT and MRI, the ability of EUS to grade IPMN of the pancreas was uncertain. The PET-CT was of high performance for the differential diagnosis between the benign and malignant IPMN of the pancreas.ConclusionsVarious imaging technologies have their own advantages in diagnosing IPMN of pancreas. MRI is currently the optimal choice when condition is permit.

    Release date:2020-03-30 08:25 Export PDF Favorites Scan
  • Prevention and control strategies for carbapenem-resistant organism in medical institutions in China: a meta-analysis

    Objective To evaluate the efficiency of prevention and control strategies of carbapenem-resistant organism (CRO) in medical institutions in China using meta-analysis method. Methods PubMed, Embase, Medline (Ovid), Web of Science, China National Knowledge Infrastructure, Chongqing VIP and Wanfang Database were systematically searched for studies on CRO prevention and control in Chinese medical institutions from the establishment of databases to 2023 for meta-analysis. Results A total of 21 studies were included, consisting of 3 randomized controlled studies and 18 non-randomized controlled studies. The meta-analysis results showed that compared with standard prevention and control measures, strengthened intervention measures (including active screening, information-based transparent supervision mode, comprehensive intervention, and bundled prevention and control strategies) could effectively reduce the CRO infection rate [relative risk (RR)=0.40, 95% confidence interval (CI) (0.25, 0.65), P<0.05]. Proactive screening could effectively reduce the CRO infection rate [RR=0.52, 95%CI (0.30, 0.91), P<0.05] and carbapenem-resistant Enterobacteriaceae (CRE) infection rate [RR=0.47, 95%CI (0.24, 0.93), P<0.05]. Information-based transparent supervision could reduce the CRE infection rate by improving compliance with standard prevention and control measures [RR=0.42, 95%CI (0.28, 0.62), P<0.05]. Conclusions Compared with standard prevention and control measures, strengthened intervention measures can effectively reduce the risk of in-hospital transmission and infection of CRO. In clinical practice, bundled comprehensive intervention can be combined with information-based transparent supervision, and if necessary, proactive screening of CRO in high-risk populations should be carried out.

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  • Preparation and applications of the polymeric micelle/hydrogel nanocomposites as biomaterials

    Polymeric hydrogels have been widely researched as drug delivery systems, wound dressings and tissue engineering scaffolds due to their unique properties such as good biocompatibility, shaping ability and similar properties to extracellular matrix. However, further development of conventional hydrogels for biomedical applications is still limited by their poor mechanical properties and self-healing properties. Currently, nanocomposite hydrogels with excellent properties and customized functions can be obtained by introducing nanoparticles into their network, and different types of nanoparticles, including carbon-based, polymer-based, inorganic-based and metal-based nanoparticle, are commonly used. Nanocomposite hydrogels incorporated with polymeric micelles can not only enhance the mechanical properties, self-healing properties and chemical properties of hydrogels, but also improve the in vivo stability of micelles. Therefore, micelle-hydrogel nanocomposites have been recently considered as promising biomaterials. In this paper, the structure, properties and methods for preparation of the micelle-hydrogel nanocomposite systems are introduced, and their applications in drug delivery, wound treatment and tissue engineering are reviewed, aiming to provide reference for further development and application of the nanocomposites.

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  • Research progress on the fluorescence resonance energy transfer-based polymer micelles as drug carriers

    Polymer micelles formed by self-assembly of amphiphilic polymers are widely used in drug delivery, gene delivery and biosensors, due to their special hydrophobic core/hydrophilic shell structure and nanoscale. However, the structural stability of polymer micelles can be affected strongly by environmental factors, such as temperature, pH, shear force in the blood and interaction with non-target cells, leading to degradations and drug leakage as drug carriers. Therefore, researches on the structural integrity and in vivo distribution of micelle-based carriers are very important for evaluating their therapeutic effect and clinical feasibility. At present, fluorescence resonance energy transfer (FRET) technology has been widely used in real-time monitoring of aggregation, dissociation and distribution of polymer micelles (in vitro and in vivo). In this review, the polymer micelles, characteristics of FRET technology, structure and properties of the FRET-polymer micelles are briefly introduced. Then, methods and mechanism for combinations of several commonly used fluorescent probes into polymer micelles structures, and progresses on the stability and distribution studies of FRET-polymer micelles (in vitro and in vivo) as drug carriers are reviewed, and current challenges of FRET technology and future directions are discussed.

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