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Meta-analysis of Finasteride for Perioperative Bleeding in Patients Undergoing Transurethral Resection of Prostate

Objective　To assess the efficacy of finasteride in treating perioperative bleeding in patients undergoing transurethral resection of the prostate (TURP). Methods　We searched MEDLINE (1966 to 2005), EMBase (1984 to 2004), CBM (1980 to 2005), The Cochrane Library (Issue 4, 2005) and relevant journals to identify cl inical trials involving finasteride in patients undergoing TURP. We also checked the references in the reports of each included trial. The qual ity of randomized controlled trials (RCTs) was assessed according to the methods recommended by The Cochrane Collaboration, and the qual ity of non-RCTs was assessed based on the methods recommended by Jiang-ping Liu, Stroup and Hailey. Two reviewers extracted data independently and data analyses were conducted with The Cochrane Collaboration’ s RevMan 4.2. Result　We included 4 RCTs and 1 non-RCT. The qual ity of 3 RCTs was graded C and the other one was graded B. The quality of the non-RCT was relatively high. Meta-analyses showed that with comparable age, international prostate symptom score, prostate specific antigen, preoperative volume of prostate and excision volume between the two groups (Pgt;0.05), the perioperative bleeding volume (WMD –85.44, 95%CI –117.31 to –53.58), the bleeding volume per gram of resected prostate tissue (WMD –3.5, 95%CI –6.34 to –0.58) and hemoglobin reduction (WMD –1.61, 95%CI –1.96 to –1.26) of the finasteride group were significantly smaller than those of the control group. Conclusion　The evidence currently available indicates that preoperative use of finasteride may reduce bleeding in patients undergoing TURP.

Comparison of Retroperitoneal Laparoscopic and Open Decortication of Renal Cysts

目的:评估经后腹腔镜与开放肾囊肿去顶减压术的临床价值。方法:回顾性调查四川大学华西医院2004年4月至2008年4月468例经后腹腔镜肾囊肿去顶减压术(A组)和2003年4月至2008年4月121例开放肾囊肿去顶减压术(B组)的临床资料并进行比较,统计分析两种术式术前,术中和术后的数据资料,比如性别、年龄、侧别、囊肿直径、手术时间、术中出血量、术后下床时间、肛门排气时间、引流管拔除时间、术后住院天数、总住院天数等。开放手术均行肋缘下切口,经后腹腔镜均行腰部常规3孔穿刺。结果:所有手术均获成功。A组手术时间5318±095分,术中出血628±033mL,术后肛门排气时间2518±030h,术后下床时间3102±022h,引流管拔除时间2715±020h,术后住院490±007d,总住院895±012d;B组手术时间6772±148分,术中出血5116±077mL,术后肛门排气时间2691±033h,术后下床时间4331±103h,引流管拔除时间2963±079h,术后住院788±018d,总住院125±029d。术前两组基线对比无统计差异。A组手术时间、术中出血量、术后下床时间、总住院天数和术后住院天数均优于B组,差异具有统计学意义(Plt;001)。术后肛门排气时间及引流管拔除时间无显著性差异(Pgt;005)。结论〓:后腹腔镜肾囊肿去顶术在手术时间、术中出血量和术后下床时间等方面明显优于开放手术。

Effectiveness and health economics evaluation of combined analgesia versus intermittent analgesia after retroperitoneal laparoscopy surgery: a retrospective cohort study

Objective To retrospectively analyze the analgesic effect and cost-effectiveness of combined analgesia versus intermittent analgesia for patients underwent retroperitoneal laparoscopic surgery. Methods We retrospectively collected clinical parameters and outcomes of analgesic effect from patients who underwent retroperitoneal laparoscopic surgery. Included patients were divided into two groups: local injection of ropivacaine combined with intermittent administration with analgesic via intravenous injection and intermittent administration with analgesic via intravenous injection only. Visual analogue scale (VAS) at different time points (2 h, 4 h, 6 h, 12 h, 24 h), usage of postoperative non-steroidal anti-inflammatory drugs (NSAIDs), adverse events, costs and other information were collected and assessed for further analysis of analgesic effect and cost-effectiveness. Results A total of 80 patients were enrolled in this study, each group consists of 40 patients. The results of this study found that VAS scores at 2 h and 4 h after operation in the combined analgesic group were significantly lower than that in the intermittent intravenous analgesia group (P<0.05), while there were no significant differences between the two groups in VAS scores at 6, 12 and 24 h after operation. The usage of NSAIDs were significantly lower in the combined group than intermittent group (P<0.05). The effective rate in the combined group was significantly higher than that in the intermittent group (P<0.05). The average cost of postoperative hospitalization and postoperative analgesic of the two groups were similar (allP values >0.05), and cost-effectiveness evaluation of the combined analgesia group was better than that of intermittent group. Conclusion Compared to intermittent administration with analgesic via intravenous injection, subcutaneous injection of ropivacaine hydrochloride combined with intermittent intravenous injection of parecoxib in patients underwent retroperitoneal laparoscopic surgery significantly could alleviate patients' painful complaints and reduce the postoperative usage of NSAIDs without increasing adverse events. Furthermore, the combination strategy has a lower cost-effectiveness ratio than intermittent group, which represents economic advantages.

高血压合并低钾血症一例

经电切镜外鞘输尿管镜气压弹道碎石术治疗下尿路结石

【摘要】　目的　总结经电切镜外鞘输尿管镜气压弹道碎石术治疗下尿路结石的疗效。　方法　2009年10月－2010年4月，采用经电切镜外鞘输尿管镜直达结石部位，采用气压弹道碎石术治疗下尿路结石20例。其中男15例，女5例；年龄35~80岁，平均54岁。膀胱结石18例，后尿道（尿道膜部）结石2例，结石直径0.5~2.0 cm，均为单发。病程6 h~2年，平均15 d。　结果　20例均一次性成功碎石，碎石成功率100%。碎石时间15~45 min，平均27 min；术后住院时间2~6 d，平均3.7 d。术后无大出血、水中毒、感染等术后早期并发症。13例患者获随访，随访时间1~3个月，平均1.2个月。所有患者均未出现结石复发、尿道狭窄等并发症。　结论　经电切镜外鞘输尿管镜下气压弹道碎石术治疗下尿路结石疗效确切、微创，是一种治疗下尿路结石的安全方法。

Advance of varicocele on testicular spermatogenesis

Varicocele (VC) is one of the common diseases of the male genitourinary system, and its incidence is higher in young adults. Among them, 80%-98% of VC are more likely to occur in the left spermatic vein. Previous research has found that VC could affect the temperature of the local microenvironment of the testis, oxidative stress process in the spermatogenic environment, mitochondrial function of sperm, endocrine system, and apoptosis of testes and epididymal cells. Therefore, VC will have an important impact on spermatogenic process of the testicles to cause male infertility. However, the specific molecular mechanism of VC affecting male spermatogenesis has not been fully studied. Therefore, this article will review the effect and mechanism of VC on testicular spermatogenesis.