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find Author "李云" 4 results
  • Th1/Th2失衡与疾病相关性的研究进展

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • 癫痫与抗癫痫药物影响男性生殖功能作用机制的研究进展

    随着国家三孩政策的开放,有生育需求的男性越来越多,越来越注重生殖健康。长期以来,癫痫患者生殖健康的关注主要在女性群体中,而对于男性癫痫患者生殖健康的研究较少。但据流行病学统计,男性癫痫患者多于女性。此外,有研究发现癫痫本身与抗癫痫药物对男性生殖功能均会产生不利影响。本文对癫痫本身与抗癫痫药物对男性癫痫患者生殖功能产生不利影响的作用机制作一综述。

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  • VARIETY AND CLINICAL SIGNIFICANCE OF IL-6 AND sTNFR LEVELS IN ACUTE PANCREATITIS

    Objective To study the variety and the action of inflammatory cytokines and the relevant anti-inflammatory factors in acute pancreatitis (AP). Methods The authors observed the change of peripheral blood IL-6 and sTNFR in 41 patients with mild and severe AP in two groups on 1, 5, 14d after acute attack by ELISA. Results All cases recovered gradually in mild group (n=22) after five days. Twelve patients improved gradually in severe group (n=19) after 5-7 days. The level of sTNFR increased markedly in 2 groups at 1, 5, 14d(P<0.001), and that of the severe group was markedly higher decreased gradually (P<0.01). The level of IL-6 increased apparently only in severe group on 1d, 40.38 pg/ml∶12.4 pg/ml, (P<0.001). The levels of IL-6 and sTNFR correlated respectively with severity of AP. Conclusion These results show that peripheral blood IL-6 and TNFα are useful index to supervise the severity and conversion and final results of AP.

    Release date:2016-09-08 02:01 Export PDF Favorites Scan
  • Preliminary study in the influencing factors of reproductive function in male patient with epilepsy

    ObjectiveTo analyse baseline information, semen, sex hormones and sexual function to understand the differences between male patient with epilepsy(MPWE) and healthy men. At the same time, we preliminarily evaluated the risk factors related to reproductive function in MPWE to provide clinical method for reducing the risk of infertility.MethodsWe collected data of 112 MPWE in the Department of Neurology, First Affiliated Hospital of Dali University from February 2019 to February 2020. Sixty-seven healthy male volunteers matching the age of the survey group were selected. All men completed semen and sex hormone test. Men with sexual life experience completed the International index of erectile function scale (IIEF-5) and the Premature ejaculation diagnostic tool (PEDT). MPWE completed the Quality of life in epilepsy-1(QOLIE-31). The baseline data, semen quality, sex hormone level and sexual function questionnaire scores of MPWE and healthy controls were compared. In addition, according to the diagnostic criteria of abnormal male reproductive function, MPWE were divided into abnormal group and normal group. Single factor analysis and binary logistic regression analysis were used to preliminarily explore the related risk factors of reproductive function in MPWE.ResultsCompared with the healthy control group, the proportion of married and childbearing, testosterone level, sperm concentration, sperm survival rate and IIEF-5 score in MPWE were significantly reduced (P<0.05). Compared with the normal group, age, body mass index, seizure frequency and drug type in the abnormal group were significant differences statistically (P<0.05). The total score and energy score of QOLIE-31 in the abnormal group were significantly lower than that in the normal group (P<0.05). Binary Logistic regression analysis indicated that energy score [B=−0.033, OR=0.967, 95%CI(0.937, 0.999)], age [B=0.879, OR=2.408, 95%CI (1.070, 5.416)], seizure frequency [B=1.788, OR=5.976, 95% CI (2.031, 17.589)].ConclusionThe reproductive function of MPWE is lower than that in healthy men. The total score, energy score, age, body mass index, seizure frequency and type of drugs will significantly affect the reproductive function of MPWE. Energy score, age and seizure frequency are independent risk factors that affect the reproductive function of MPWE. Abnormal reproductive function of MPWE was positively correlated with age and seizure frequency, but negatively correlated with energy score.

    Release date:2021-02-27 02:57 Export PDF Favorites Scan
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