ObjectiveTo evaluate the prognostic significance of metastatic lymph nodes ratio (MLNR) in patients with node-positive breast cancer. MethodsThe clinical data of 94 patients with nodepositive breast cancer underwent modified radical mastectomy were retrospectively analyzed. The survival rate and prognosis factors of patients with complete follow-up data were assessed by log-rank test and multivariate regression analysis. Results The survival time of 94 patients ranged from 12-75 months, with median 64 months. The 5-year overall survival rate was 72.34% (68/94). The total MLNR was 0.31 (486/1 553). Univariate analysis demonstrated that the survival was influenced significantly by tumor size, number of lymph node metastasis, MLNR, ER status, and radiotherapy or not (Plt;0.05), but not by patient’s age, menopause or not, PR status, endocrine therapy or not, and histological type (Pgt;0.05). Multivariate analysis showed that MLNR (OR=2.565, 95%CI=1.043-6.309， P=0.040) and tumor size (OR=2.220, 95%CI=1.045-4.716， P=0.038) were independent prognostic factors for the patients with node-positive breast cancer. Conclusion MLNR is a major independent prognostic factor for the patients with node-positive breast cancer, which is more accurate than the number of metastatic lymph nodes in predicting the survival of patients with node-positive breast cancer.
目的探讨副乳腺癌的诊断和治疗方法。 方法回顾性总结我院收治的1例副乳腺癌患者的临床病理资料，并结合相关文献进行分析。 结果该例患者临床表现为左腋下肿块，彩超及钼靶检查均提示恶性可能性大，病理报告证实为副乳腺癌。 行左副乳腺和左乳腺切除加左腋窝低位淋巴结清扫术，术后病理报告： 左副乳腺浸润性导管癌Ⅱ级，左副乳腺内见浸润性导管癌组织，淋巴结无转移。术后给予化疗（EC×4序贯T×4），生存9个月，现仍在随访中。 结论对腋下肿块而双乳未见确切肿块的患者应警惕副乳腺癌的存在，以免延误诊治。
ObjectiveTo observe the clinical efficacy of temperature-controlled self-heated pain relief plasters in the treatment of chronic nonspecific lower back pain, and to investigate the quality of life of patients. MethodsPatients with chronic nonspecific lower back pain were randomly divided into a trial group and a control group. The trial group was treated with temperature-controlled self-heated pain relief plasters, while the control group was treated with meloxicam tablets for oral use. The outcome measures including the visual analogue pain scale (VAS), Japanese Orthopedic Association (JOA) scores for the management of lower back pain, and Oswestry disability index (ODI score) were collected before treatment and after 6-month follow-up. SPSS 13.0 software was used for statistical analysis. ResultsA total of 96 patients was included (48 patients in each group), of which 68 patients (36 in the trial group and 32 in the control group) completed the treatment. The results of intention-to-treat (ITT) and per-protocol (PP) analyses showed that the total effectiveness rate of the trial group was higher than that of the control group with significant differences (all P values < 0.05). Compared with those before treatment, the JOA scores and ODI scores of the two groups were all improved after 6-month follow-up (all P values < 0.05). But no significant difference was found between the two groups in the two scores after 6-month follow-up (all P values > 0.05). During the follow-up, there were 3 and 8 patients with recurrence of lower back pain in the trial group and the control group, respectively. ConclusionThe clinical effect of temperature-controlled self-heated pain relief plasters in the treatment of chronic nonspecific lower back pain is satisfactory, the quality of life of patients is improved obviously, and the therapy is simple, safe, inexpensive, and worthy of clinical promotion.