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find Author "李秀" 7 results
  • High-Dose Chemotherapy Assisted with Autologous Peripheral Blood Stem Cell Treatment for Small Cell Lung Cancer: A Meta-Analysis

    Objective  To assess the effectiveness and safety of high-dose chemotherapy assisted with autologous peripheral blood stem cell treatment (APBSCT+HDC) for small cell lung cancer (SCLC). Methods  The databases such as MEDLINE (1970 to January 2011), EMBASE (1980 to January 2011), Science Direct (1980 to January 2011), The Cochrane Library (Issue 3, 2010), CNKI (from the date of establishment to December 2010), CBM (from the date of establishment to December 2010) and Wanfang database (from the date of establishment to December 2010) were searched for collecting randomized controlled trials (RCTs) on APBSCT+HDC for SCLC. According to the inclusive and exclusive criteria, the trials were screened, the data were extracted, the methodological quality was assessed, and then Meta-analysis was conducted by using RevMan 5.0 software. Results  A total of 6 RCTs involving 737 patients with SCLC were included. The results of Meta-analyses were as follows: the APBSCT+HDC for SCLC was significantly superior to the conventional chemotherapy in the total effective rate (RR=1.14, 95%CI 1.07 to 1.21, Plt;0.000 1) and the overall survival rate (RR=3.74, 95%CI 2.13 to 6.58, Plt;0.000 01), and it was superior in reducing the incidence of III/IV grade red blood cell reduction (RR=1.97, 95%CI 1.15 to 3.38, P=0.01) and thrombopenia (RR=1.93, 95%CI 1.06 to 3.54, P=0.03) with significant differences; but there was no significant difference between the two groups in reducing the incidence of III/IV leukopenia. Conclusions  Compared with the conventional chemotherapy, APBSCT+HDC treatment for SCLC can improve the overall effective rate and overall survival rate, but it can also increase the risks of severe hematologic toxic reaction. Because of the small scale and low quality of the included studies, this conclusion still needs to be confirmed by high-quality, large-scale and multi-centered RCTs.

    Release date:2016-08-25 02:39 Export PDF Favorites Scan
  • 慢性阻塞性肺疾病患者合并焦虑的相关因素分析

    目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者合并焦虑的相关因素。方法分析安徽医科大学第三附属医院 2015 年 10 月至 2018 年 10 月住院治疗的慢阻肺患者 70 例。所有患者于出院前完成汉密尔顿焦虑量表(HAMA)调查及相关临床资料和社会人口学资料的采集,并于出院后 1 周门诊复诊时采集血标本,检测血清 C 反应蛋白(CRP)。根据 HAMA 评分将慢阻肺患者分为焦虑组和对照组,采用 Logistic 回归分析方法分析慢阻肺患者合并焦虑的相关因素。结果70 例慢阻肺患者中 44 例合并焦虑。较高学历的慢阻肺患者更易产生焦虑情绪,初中及以上、小学、小学以下合并焦虑的占比分别为 86.7%、47.4%、42.9%(P=0.002)。合并焦虑的慢阻肺患者的第 1 秒用力呼气容积(FEV1)较对照组更倾向于低水平[0.71(0.52,0.99)L 比 0.99(0.86,1.45)L,P=0.001]。焦虑组慢阻肺患者 CRP 水平较对照组高[13.1(0.47,18.18)mg/L 比 0.80(0.49,3.43)mg/L,P=0.000]。结论高血清 CRP 水平、高学历、低 FEV1 是慢阻肺患者合并焦虑的高危因素。

    Release date:2020-09-27 06:38 Export PDF Favorites Scan
  • 2020 American College of Rheumatology guideline for the management of gout: an interpretation

    Gout is the most common inflammatory arthritis, which is characterized by elevated urate and monosodium urate (MSU) crystal deposition in tissues, leading to arthritis, soft-tissue masses (tophi), nephrolithiasis, and urate nephropathy. It has a major impact on health-related quality of life. The American College of Rheumatology (ACR) published ACR guidelines for the management of gout in June 2020, in which 42 recommendations (including 16 strong recommendations) were generated. The guideline described indications for urate-lowering therapy (ULT), approaches to initiating, ongoing management, gout flares, and lifestyle and other medication strategies in patients with gout and in individuals with asymptomatic hyperuricemia. This paper interprets it to provide references for clinical practice.

    Release date:2021-05-25 02:52 Export PDF Favorites Scan
  • An updated interpretation of 2019 EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies

    Psoriatic arthritis (PsA) is a disease with heterogeneous manifestations in patients who have manifest or latent psoriasis. It comprises both musculoskeletal and non-musculoskeletal manifestations. Active chronic PsA is often accompanied by cardiovascular, psychological and metabolic complications. Although the quantity of disease-modifying antirheumatic drugs (DMARDs) indicated for PsA has increased, clinicians still require some guidance in decision-making. Based on the latest evidence-based research results, the European League Against Rheumatism (EULAR) in 2019 developed the recommendations for the pharmacological management of PsA updated in 2015 with new recommendations. This paper interprets the update contents of the guideline to provide references for the clinical treatment of PsA.

    Release date:2021-04-23 04:04 Export PDF Favorites Scan
  • Role of aspergillus infection in bronchiectasis and its diagnosis and treatment

    Bronchiectasis is a heterogeneous disease characterized by abnormal expansion of the bronchi, manifested by cough, sputum, and recurring lung infections. As one of the common fungi of lung infection, aspergillus can not only appear as the outcome of the disease in bronchiectasis, but also as an inducement to participate in the disease progression, and ultimately complicate the course of bronchiectasis. This article describes the susceptibility factors and pathogenic mechanisms of aspergillus in bronchiectasis, and further introduces the diagnosis and treatment status of bronchiectasis combined with aspergillus infection, aiming to clarify the effect of aspergillus infection on bronchiectasis and provide new thinking directions for its clinical diagnosis and treatment.

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  • Analysis and application of avoidable mortality in health evaluation

    Avoidable mortality (AM) is an important indicator of health system performance. It is also an effective tool for evaluating the effectiveness of health measures and allocation of health resources. The concept development, analytical methods, and research contents of avoidable mortality are introduced in this study. This study investigated the applicability of avoidable mortality analysis in determining priority health-service intervention areas, determining priority health-service intervention populations and evaluating the quality of those services. This paper also discussed the significance and limitations of avoidable mortality analysis. The investigation provided references for further research and application of avoidable mortality analysis.

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  • Effects of noninvasive positive pressure ventilation in COPD with hypercapnic coma secondary to respiratory failure

    Objective To study the effect of noninvasive positive pressure ventilation (NPPV) in chronic obstructive pulmonary disease (COPD) patients with hypercapnic coma secondary to respiratory failure.Methods COPD patients with or without coma secondary to respiratory failure were both treated by bi-level positive airway pressure (BiPAP) ventilation on base of routine therapy.There were 32 cases in coma group and 42 cases in non-coma group.Such parameters as arterial blood gas (ABG),Glasgow coma scale (GCS),time of NPPV therapy,achievement ratio,and adverse effects were investigated.Results 30 patients in the coma group were improved after NPPV treatment (26 cases recovered consciousness treated by BiPAP in 2 hours,3 cases recovered between 3~8 hours,1 case recovered after 24 hours).The parameters of ABG,the tidal volume and the minute ventilation volume were improved after BiPAP.The time of effective therapy was (9±4) days in the coma group and (7±3) days in the non-coma group with no significant difference (Pgt;0.05).The achievement ratio was similar in two groups (93.75% vs 97.62%,Pgt;0.05).But the incidence of gastrointestinal tympanites reached to a higher level in the coma group (80.5%) than the non-coma group (10.6%).Conclusion COPD patients with hypercapnic coma secondary to respiratory failure isn’t the absolute contraindication of NPPV treatment.

    Release date:2016-08-30 11:35 Export PDF Favorites Scan
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