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find Author "李红岩" 2 results
  • 胸腺基质淋巴细胞生成素在哮喘Th2优势免疫中的作用

    支气管哮喘( 简称哮喘) 是以树突状细胞( DC) 介导的Ⅱ型辅助性T 细胞( Th2) 优势免疫为特征的慢性气道炎症性疾病。哮喘气道产生大量的促炎症细胞因子, 募集嗜酸粒细胞、肥大细胞和淋巴细胞等炎症细胞, 释放一系列炎症因子, 引起气道炎症、黏膜水肿、黏液分泌和血管扩张等过敏症状。其中, 来源于上皮细胞的胸腺基质淋巴细胞生成素( thymic stromal lymphopoietin, TSLP) 在哮喘患者体内高表达, 在Th1/Th2 免疫失衡中起重要作用, 业已引起广泛关注。尤其随着对TSLP和TSLP受体( TSLPR) 的成功克隆与测序, TSLP 活化DC、启动Th2 免疫应答的分子机制, 以及TSLP在哮喘炎症上游阶段中的功能逐渐被识别, 人们对哮喘的免疫学发病机制有了更新的认识。

    Release date:2016-08-30 11:55 Export PDF Favorites Scan
  • Early effectiveness of arthroscopic superior fulcrum reconstruction in treatment of irreparable massive rotator cuff tear

    ObjectiveTo investigate early effectiveness of arthroscopic superior fulcrum reconstruction in the treatment of irreparable massive rotator cuff tear (IMRCT). Methods A retrospective analysis was conducted on the clinical data of 24 patients with IMRCT who met the inclusion criteria between January 2020 and April 2022. Among them, there were 11 males and 13 females with an average age of 56.2 years (range, 42-68 years). There were 12 cases of falling injuries, 3 cases of traction injuries, and the other 9 cases had no obvious causes. The disease duration ranged from 1 to 25 months (median, 6 months). The rotator cuff tears were classified as Hamada grade 2 in 18 cases and grade 3 in 6 cases, and Goutallier grade 1 in 3 cases, grade 2 in 20 cases, and grade 3 in 1 case. All patients were treated with arthroscopic superior fulcrum reconstruction. Visual analogue scale (VAS) score, Constant-Murley score, the University of California at Los Angeles (UCLA) score, and the American Shoulder and Elbow Surgeons (ASES) score were recorded before operation and at 1, 3, 6, and 12 months after operation. Results The operations were all successfully completed. The incisions healed by first intention and no related complications occurred. All patients were followed up 12-33 months (mean, 24.6 months). The VAS, Constant-Murley, UCLA, and ASES scores at different time points after operation were superior to those before operation (P<0.05). All of the above indicators further improved with time. Except for no significant difference in VAS and Constant-Murley scores between 6 and 12 months (P>0.05), the differences between the other time points were significant (P<0.05). At 12 months after operation, according to UCLA scoring standard, shoulder joint function was rated as excellent in 4 cases, good in 19 cases, and poor in 1 case, with an excellent and good rate of 96.0%. MRI showed that there was no graft re-tear and the transplanted tendon and bone tunnel healed. Conclusion The arthroscopic superior fulcrum reconstruction for IMRCT can effectively relieve the pain, improve the shoulder range of motion, and restore good shoulder function.

    Release date:2023-12-12 05:09 Export PDF Favorites Scan
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