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find Author "李辉" 47 results
  • 管状胃技术在食管重建中的应用

    Release date:2016-08-30 06:01 Export PDF Favorites Scan
  • Some thoughts on immunotherapy for esophageal squamous cell carcinoma

    Great progress has been made in immunotherapy for esophageal squamous cell carcinoma in recent years. However, for thoracic surgeons, immunotherapy is still a new thing and they lack enough experience. Therefore, this paper attempts to discuss some hot issues of immunotherapy, including the indications, side effects, clinical efficacy and evaluation of efficacy. The author hopes that this article will help and attract the attention of thoracic surgeons.

    Release date:2021-03-05 06:30 Export PDF Favorites Scan
  • Interpretation of guideline for the prevention and management of perioperative venous thromboembolism in thoracic malignancies in China (2022 version)

    Patients with thoracic malignancy have a high incidence of perioperative venous thromboembolism (VTE), but its onset is insidious, often asymptomatic or atypical, and is easily overlooked. Early identification and standardized prevention of VTE can effectively reduce the risk of VTE. "Guideline for the prevention and management of perioperative venous thromboembolism in thoracic malignancies in China (2022 version)" has been officially released recently. This article closely follows the context, significance, core implications, and the impact of future VTE prevention in thoracic surgery. It is hoped that through our joint efforts, we can reduce the incidence of perioperative VTE and mortality of thoracic surgery, and strive to improve the long-term survival of patients with lung cancer and esophageal cancer.

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  • 单孔胸腔镜肺手术的扶镜体会与思考

    Release date:2018-11-27 04:47 Export PDF Favorites Scan
  • Early Experience of Combined Laparoscopic and Thoracoscopic Esophagectomy and Intrathoracic Esophagogastric Anastomosis

    Abstract: Objective To evaluate the feasibility and safety of combined laparoscopic and thoracoscopic esophagectomy and intrathoracic esophagogastric anastomosis for the treatment of esophageal cancer. Methods We retrospectively analyzed clinical data of 40 patients with esophageal cancer who underwent esophagectomy in Beijing Chaoyang Hospital of Capital Medical University from March 2010 to March 2012. All the 40 patients were divided into 2 groups according to their different surgical approach, including 22 patients who underwent combined laparoscopic and thoracoscopic esophagectomy and intrathoracic esophagogastric anastomosis (minimally invasive surgery group) and 18 patients who underwent Ivor Lewis esophagectomy (open surgery group). Operation time, intra-operative blood loss, lymph node dissection, postoperative morbidity, hospital stay and cost were compared between the two groups. Results The hospitalcost of minimally invasive surgery group was significantly higher than that of open surgery group [(78 181.5±8 958.8) yuan vs. (61 717.2±35 159.4) yuan, Z=4.078,P=0.000] . There was no statistical difference in operation time [(292.0±74.8) min vs. (256.1±41.0) min, t=1.838,P=0.074], intra-operative blood loss [(447.7±597.0) ml vs. (305.6±125.9) ml, Z=0.401,P=0.688], total number of dissected lymph nodes (230 vs. 215, t=1.714,P=0.095), postoperative morbidity [22.7% (5/22) vs. 33.3% (6/18), χ2=0.559,P=0.498], time to resume oral intake [(8.5±3.5) d vs. (11.1±9.6) d,t=1.202,P=0.237], and postoperative hospital stay [(11.6±5.7) d vs. (13.3±9.4) d, t=0.680, P=0.501)] between the two groups. The minimally invasive surgery group was further divided into two subgroups according to operation date, including 10 patients in the early stage subgroup and 12 patients in the later stage subgroup. The operation time of the later stage subgroup was significantly shorter than that of the early stage subgroup [(262.9±64.9) min vs. (327.5±73.0) min, t=2.197, P=0.040], but not statistically different from that of the open surgery group [(262.9±64.9) min vs. (256.1 ±41.0) min, t=0.353, P=0.727]. Intra-operative blood loss of the later stage subgroup was significantly reduced compared with those of the early stage subgroup [(220.8±149.9) ml vs. (720.0±808.0) ml, Z=3.279, P=0.001)] and the open surgery group [(220.8±149.9)ml vs. (305.6±125.9) ml, Z=2.089, P=0.037)]. Conclusion Combined laparoscopic and thoracoscopic esophagectomy and intrathoracic esophagogastric anastomosis is a safe and effective surgical procedure for the treatment of esophageal cancer.

    Release date:2016-08-30 05:51 Export PDF Favorites Scan
  • 右位主动脉弓致食管外压性狭窄一例

    Release date:2016-08-30 05:59 Export PDF Favorites Scan
  • Significance of Peripheral Serum Hepatocyte Growth Factor and Transforming Growth Factorβ in Preoperative Staging of Patients with Nonsmall Cell Lung Cancer

    Abstract: Objective To explore the significance of peripheral serum hepatocyte growth factor (HGF) and transforming growth factor-β (TGF-β) in preoperative staging of patients with nonsmall cell lung cancer. Methods Fifty patients, including 30 males and 20 females, with complete clinical data and final pathological diagnosis of nonsmall cell lung cancer were treated in Beijing Chaoyang Hospital from September 2006 to November 2007. Their age ranged from 36 to 76 years old (62.4±10.0 years old). Among the patients, there were 26 patients of adenocarcinoma, 23 patients of squamous cell carcinoma and one patient of large cell carcinoma. Twenty other normal subjects were chosen to form normal control, including 11 males and 9 females, aged from 18 to 67 years old (43.8±14.2 years old). Peripheral serum HGF and TGF-β were measured with enzymelinked immunosorbent assay (ELISA), and the relationship between the level of HGF, TGF-β and preoperative staging was analyzed. Results The peripheral serum HGF and TGF-β level has no relation with patient’s age, sex, smoking history or histology type. The level of HGF in the T2 and T3 patients was significantly higher than that of normal control (373.90±234.00 pg/ml vs. 211.30±154.60 pg/ml, t=2.759, P=0008; 563.80±316.10 pg/ml vs. 211.30±154.60 pg/ml, t=4076, P=0.000). The level of TGF-β in the T-3 patients was significantly higher than that of normal control (3.34±2.80 ng/ml vs. 1.82±0.90 ng/ml, t=2.190, P=0.037). The level of TGF-β in the N1-2 patients was significantly higher than that of the N0 patients (2.60±2.00 ng/ml vs. 1.53±0.74 ng/ml, t=-2.387, P=0.021). TGF-β level (5.97±2.65 ng/ml) in patients with distant metastasis (stage Ⅳ) was significantly higher than that of patients in other stages. Conclusion The HGF and TGF-β level is related to the staging of lung cancer. Such examinations combined before operation may present a reference value for preoperative staging and providing the best treatment plan for the patients.

    Release date:2016-08-30 06:03 Export PDF Favorites Scan
  • Treatment of achalasia by transthoracic Heller myotomy with a small incision

    Objective To review the clinical experience of Heller myotomy for treatment of achalasia through a small thoracotomy. Methods Twenty-five patients with achalasia (9 moderate, 16 severe) underwent Heller myotomy without concomitant antireflux procedure through a small incision. A left thoracotomy was carried out through either the seventh or eighth intercostals space. The length of skin incision was 6 to 8 cm. Results There was no hospital death and severe postoperative complications. The mean operating time was 50 minutes. Mean hospital stay was 10 days. There was one intraoperative perforation and repaired successfully. All patients reported good to excellent relief of dysphagia and no symptom of gastroesophageal reflux after surgery. Eight patients were subsequently studied with a 24-hour esophageal pH monitoring and no evidence of pathologic reflux found. Conclusions Transthoracic Heller myotomy with a small incision is effective and safe method for treatment of achalasia with minimal invasion, quick recovery, less postoperative complication and shorter hospital stay. Proper extent of the myotomy may decrease the risk of subsequent gastroesophageal reflux in the postoperative period.

    Release date:2016-08-30 06:28 Export PDF Favorites Scan
  • 国产与进口消化道吻合器的临床应用

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • 胸部开放伤后海水浸泡对实验犬呼吸功能的影响

    目的 探讨胸部开放伤后海水浸泡所致呼吸功能障碍的病理生理特点,为研究早期救治方案提供依据。方法 实验犬致伤后随机分为对照组(n=10)和海水浸泡组(n=10)。海水浸泡组:犬于致伤后置入人工配制的海水中,于致伤前及入海水后即刻、30分钟和45分钟取动脉血测定血气分析变化,同时监测通气功能和换气功能变化。对照组:不浸泡海水,于致伤前、致伤后即刻、30分钟、45分钟、1小时、2小时、3小时和4小时进行监测,处理同海水浸泡组。 结果 海水浸泡组的呼吸功能衰竭明显重于对照组,表现在严重的低氧血症和高碳酸血症,而且出现的时间早。对照组低氧血症的主要原因是以通气/灌注比率失调为主的换气功能障碍,同时并存一定程度的限制性通气功能障碍;而造成海水浸泡组低氧血症和高碳酸血症的主要原因是以严重肺泡通气不足为主的通气功能障碍和肺内分流引起的换气功能障碍。 结论 胸部开放伤后海水浸泡组与对照组所造成呼吸功能障碍的机制有所不同,前者可造成严重的Ⅱ型呼吸衰竭,对生命威胁更大

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
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