ObjectiveTo systematically review the association between PVT1 expression and digestive system tumors (DST). MethodsPubMed, EMbase, Web of Science, The Cochrane Library, CBM, and CNKI databases were electronically searched to collect case-control studies on the correlation between PVT1 expression and DST from inception to June 2021. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Meta-analysis was then performed by using Stata 16.0 software. ResultsA total of 34 case-control studies involving 3 882 DST patients were included. The results of meta-analysis showed that the high expression of PVT1 was significantly associated with tumor size (>5 cm), differentiation degree (poor), T stage (T3-T4), lymph node metastasis (N+), distant metastasis (M+), and clinical stages (Ⅲ-Ⅳ) of DST; however, it was not associated with gender, age and venous invasion. In addition, the high expression of PVT1 in DST tissues was significantly correlated with the low rates of 1, 3 and 5-year overall survival and poor prognosis (HR=1.96, 95%CI 1.70 to 2.26, P<0.000 1). Subgroup analysis showed that the high expression of PVT1 was significantly associated with poor prognosis of gastric cancer, colorectal cancer, pancreatic cancer and liver cancer.ConclusionsCurrent evidence shows that the high expression of PVT1 is correlated with the clinic pathological features (tumor size >5 cm, poor differentiation, T3-T4 stage, lymph node metastasis, distant metastasis, and clinical stage Ⅲ-Ⅳ) and indicates poor prognosis in most patients with DST (gastric cancer, colorectal cancer, pancreatic cancer, liver cancer).
目的 探讨腹腔镜下行直肠癌根治术（L-Dixon，L-Miles）的应用价值。方法 对我院2009年10月至2011年1月期间收治的68例行腹腔镜直肠癌根治术患者的临床资料进行回顾性分析。结果 68例患者中行L-Dixon术55例，L-Miles术12例，中转开腹行Dixon术1例，手术过程顺利。术后第4天1例并发吻合口漏、盆腔脓肿，行开腹引流、横结肠造瘘术，6个月后关闭瘘口，恢复正常。本组患者随访时间2～12个月，平均随访时间8个月，均恢复良好，无肿瘤复发及转移。结论 腹腔镜下行直肠癌根治术具有手术野清晰、创伤小、恢复快等优点，可取得与开腹手术相当或更好的根治效果，使患者受益。