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Clinical study on the effect of polycythemia on retinopathy of prematurity

Objective　To explore the effect of polycythemia on retinopathy of prematurity (ROP). Methods　The clinical data of 262 premature cases was analyzed retrospectively in Xi'an Children Hospital from January 2005 to January 2009. Polycythemia was found in 46 cases (17.56%), including 27 males and 19 females. In 216 infants without polycythemia (82.46%), 155 were male and 61 were female. The difference of the birth weight (t=0.730, P=0.466), gestational age (t=1.603,P=0.110), oxygen inhalation numbers (chi;2=0.04,P＞0.90) and times (t=1.225,P=0.223), and concentration (t=1.823,P=0.071) between polycythemia group and no polycythemia group were not significant. In order to diagnose ROP, the ocular fundus of all premature infants was examined with binocular indirect ophthalmoscope,and the stage of ROP was assessed.Results　In all the premature infants,ROP was found in 120 cases (45.80%). In 46 cases of polycythemia, ROP was found in 25 cases (54.34%); in 216 infants without polycythemia, ROP was found in 95 cases (43.98%); the difference of ROP incidence between the two groups was not significant (chi;2=1.64, Pgt;0.1).In 120 ROP patients, 104 cases (86.67%) with ROP＜3 stage and 16 cases (13.33%) with ROP ge;3 stage were found. In 25 ROP patients with polycythemia, 18 cases (72.00%) with ROP ＜3 stage and 7 cases (28.00%) with ROP ge;3 stage were found. In 95 ROP patients without polycythemia, 86 cases (90.53%) with ROP ＜3 stage and 9 cases (9.47%) with ROP ge;3 stage were found. The difference of the incidence of ROP ＜and ge;3 stage between the two group was significant (chi;2=4.38, Plt;0.05). In 120 cases of ROP, prethreshold retinopathy was found in 106 cases (88.33%), while threshold and post-threshold retinopathy was in 14 cases (11.67%). In 25 ROP patients with polycythemia, prethreshold retinopathy was found in 19 cases (76.00%), and threshold and post-threshold retinopathy was in 6 cases (24.00%).In 95 ROP infants without polycythemia, pre-threshold retinopathy was found in 87 cases (91.58%),while threshold and post　threshold retinopathy was in 8 cases (8.42%).The difference of the incidence of ROP with prethreshold, and threshold and post-threshold retinopathy between the two groups was not significant (chi;2=3.27,P＞0.05).Conclusion　Polycythemia may not affect the incidence of ROP,but impact on the severity of ROP.

过氟-N-辛烷和眼内光凝治疗视网膜巨大裂孔

女性Eales病八例

目的：评价女性Eales病的临床特征及对持久的玻璃体出血和牵拉性视网膜脱离的玻璃体手术效果。 方法：复习本科1993年4月至1994年12月经玻璃体手术治疗的该病患者的病历记录。 结果：8例（11只眼）女性患者占同期该病患者的22%，年龄19~35岁，平均病史10.8个月，急性发病后持久出血及视力严重丧失，伴视盘和周边部新生血管膜及黄斑水肿。10只眼玻璃手术后视力明显改善8只眼，0.2~1.0者6只眼。1眼有早期周边部血管白鞘，经氩激光光凝。 结论：女性Eales病的特点可能包括年龄轻，病史短，急性发作，有持久出血和新生血管膜形成。玻璃手术能有效改善多数眼的视力。 （中华眼底病杂志，1996，12：51-52）

DAUNOMYCIN ENCAPSULATED IN LIPOSOMES IN THE TREATMENT OF EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY

An experimental model of proliferative vitretinopathy(PVR) induced by macrophages was used for the evaluation of drug efficacy of daunomycin encapsulated in liposomes in the treatment of PVR.Five mu;g daunomycin(n=40),10mu;g daunomycin-liposome(DL,n=30)and 0.1 ml saline or empty liposomes(n=40,as controls)were injected into the rabbit vitreous after macrophage injection.Retinal detachment developed in 77.5% of the control eyes on day 28,compared to 33.3% of the eyes treated with DL(P＜0.01)and 50% of the daunomycin-treated eyes(P＜0.05).The results suggest that encapsulation in liposomes of cytotoxic agents can enhance drug efficacy.The phasic course of development of PVR is important in the selection of particular drugs. （Chin J Ocul Fundus Dis,1993,9:77-80）