ObjectiveTo explore perioperative management model of ABO-incompatible liver transplantation. MethodsThe clinical data of ABO-incompatible caderveric liver transplantions without urgency performed in our center from July 2006 to May 2010 were analyzed retrospectively. Four patients had received an ABO-incompatible graft: AB to O in three, AB to A in one. All the cases were diagnosed as end-stage liver disese, one of them was primary hepatocellular carcinoma. ResultsFour survived to now （11 to 19 months） without severe infections and acute rejections. Two experienced coagulative disturbance and one of them had a second exploration. One developed acute renal failure and recovered with help under continuous veno-venous hemofiltration. All the cases were given 20 mg basiliximab two hours before revascularization and on day 4 after operation respectively. Splenectomy was performed in three, intravenous immunoglobulin was given in all more than seven days. Isohemagglutinin titers were basically stable and not relevant to the clinical manifestations. Antibiotic prophylaxis and immunosuppression protocol was same as the ABO compatible transplants except a 3-month-delay for steroid withdrawal. ConclusionABO-incompatible liver transplantation could be performed with appropriate perioperative management, such as basiliximab induction, splenectomy, intravenous immunoglobulin administration, and routine immunosuppression.
目的探讨胰腺损伤的诊断和治疗方法。 方法回顾性分析16例胰腺损伤患者的临床资料。 结果胰腺损伤属Ⅰ级3例，Ⅱ级5例，Ⅲ级4例，Ⅳ级3例，Ⅴ级1例；系单纯胰腺损伤3例，合并其他器官损伤13例。术前确诊为胰腺损伤者9例，另7例分别诊断为：脾破裂1例，肝破裂1例，开放性腹部损伤2例，空腔脏器穿孔、弥漫性腹膜炎3例。8例胰腺Ⅰ～Ⅱ级损伤者行清创、缝扎止血及胰腺周围双套管引流术；4例Ⅲ级损伤者行胰体尾切除+脾切除术；3例Ⅳ级损伤者，行近端胰腺断端缝合、胰管缝扎加胰体尾空肠Roux-en-Y吻合术；对1例Ⅴ级损伤者行胰十二指肠切除术。术后发生胰瘘5例；治愈13例，死亡3例。 结论早期诊断、及时手术探查以及术中选择合理的手术方式，对降低胰腺损伤的并发症和死亡率和改善胰腺损伤的预后均十分重要。