west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "段群欢" 2 results
  • COPS3在肝癌中的表达

    目的研究构成型光形态建成同源亚基3(COPS3)在肝癌中的表达。 方法应用免疫组织化学SP法及RT-PCR法检测肝癌组织中COPS3表达情况。 结果肝癌组织中COPS3蛋白表达阳性率〔46.7%(14/30)〕明显高于正常肝脏组织〔23.3%(7/30),χ2=5.654,P=0.017〕及肝硬变组织〔36.7%(11/30),χ2=4.979,P=0.026〕,差异具有统计学意义。肝癌组织中COPS3 mRNA的转录水平亦明显高于肝硬变及正常肝脏组织,差异具有统计学意义(P<0.05);在肝癌组织中,COPS3在细胞核中的表达阳性率明显高于在细胞浆中的表达阳性率(χ2=6.674,P=0.009)。 结论COPS3在肝癌组织中表达水平和定位均发生改变,可能参与了肝癌的发生和发展过程。

    Release date:2021-06-24 01:08 Export PDF Favorites Scan
  • Evaluation on APACHEⅡ Score for Deep Fungal Infection in Patients with Severe Acute Pancreatitis at Admission

    Objective To evaluate the predicted value of APACHEⅡ score at admission for deep fungal infection(DFI) in patients with severe acute pancreatitis (SAP).Methods The clinical data of 132 patients with SAP from January 2006 to June 2011 in our hospital were analyzed retrospectively. The receiver operating characteristic curve (ROC) was used for evaluating the predicted value.Results Thirty-nine patients with SAP infected DFI (29.5%),of which 36 patients (92.3%) infected with Candida albicans,2 patients (5.1%) with Candida tropicalis,1 patient (2.6%) with pearl bacteria.And,among these 39 patients,27 patients (69.2%) infected at single site,12 patients (30.8%) infected at multi-site. The APACHEⅡ score in 39 patients with DFI was higher than that of 93 patients without DFI (17.1±3.8 versus 9.7±2.1, t=14.316,P=0.000).The ROC for APACHEⅡ score predicting DFI was 0.745(P=0.000), 95%CI was 0.641-0.849.When the cut off point was 15,it showed the best forecast performance,with specificity 0.81, sensitivity 0.72,Youden index 0.53. Conclusions The APACHEⅡ score at admission can preferably predict DFI in patients with SAP; when the APACHEⅡ score is greater than 15,it prompts highly possible of DFI,so preventive anti-fungal treatment may be necessary.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content