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find Keyword "氯雷他定" 3 results
  • 西替利嗪滴剂治疗慢性荨麻疹近期疗效观察

    【摘要】 目的 观察西替利嗪滴剂治疗慢性荨麻疹的疗效。 方法 选择2011年4月-2011年8月间80例慢性荨麻疹患者为研究对象,试验组40例给予西替利嗪滴剂1次/d,10 mg/次;对照组40例给予氯雷他定1次/d,10 mg/d,均连续服用28 d。分别于用药后第7、28天随访,观察疗效和不良反应。 结果 试验组治疗7、28 d有效率分别为72.5%、87.5%,对照组有效率分别为67.5%、85.0%,两组比较差异无统计学意义(χ2=0.060,0.081;Pgt;0.05)。 结论 口服西替利嗪滴剂或氯雷他定10 mg/d治疗慢性荨麻疹疗效相似,但滴剂剂量调整更准确,在慢性荨麻疹缓解期的维持减量阶段应用更方便。

    Release date:2016-08-26 02:18 Export PDF Favorites Scan
  • Efficacy and Safety of Desloratadine in Chronic Urticaria: A Systematic Review

    Objectives To evaluate the efficacy and safety of desloratadine in the patients with chronic urticaria(cu). Methods We searched PubMed, Blackwell, BIOSIS Preview, The Cochrane Library, VIP and CNKI electronically from January 1, 2000 to April, 2008. Relevant journals and conference proceedings were also handsearched. Randomized controlled trials (RCTs) and quasi-RCTs comparing desloratadine with other medicines in the patients with CIU were considered eligible. The quality of the included trials was assessed by the Jadad scale, and meta-analysis was conducted using RevMan 5.0 software. Results Nineteen trials involving 3,448 participants contributed to the meta-analysis. The results of the meta-analysis indicated that desloratadine showed similar effect on the improvement of signs and symptoms compared with loratadine RR 1.04 and 95%CI 0.99 to 1.09, mizolastine in RR 0.99 and 95%CI 0.92 to 1.07, cetirizine RR 1.05 and 95%CI 0.97 to 1.13 and terfenadine RR 1.10 and 95%CI 0.84 to 1.44. And desloratadine had similar safety to mizolastine RR 0.84 and 95%CI 0.45 to 1.58, ceririzine RR 0.67 and 95%CI 0.67 and 0.39 to 1.15 and terfenadine RR 0.44 and 95%CI 0.17 to 1.10. Desloratadine was safer than loratadine RR 0.74 and 95%CI 0.55 to 1.00. Conclusions Desloratadine, the active metabolite of loratadine, is an oral, once-daily, non-sedating antihistamine that is effective in the treatment of CIU. Desloratadine provides rapid and sustained relief of CIU symptoms.

    Release date:2016-09-07 02:10 Export PDF Favorites Scan
  • Randomized Controlled Trial of Compound Loratadine Capsule in the Treatment of Allergic Rhinitis

    Objective To evaluate the clinical effectiveness and safety of compound loratadine capsule in the treatment of allergic rhinitis. Methods A multi-center randomized single blind controlled trial (by using a random number table generated random sequence and the sequence was concealed by sealed envelopes) was designed. Two hundred and forty outpatients with allergic rhinitis who met the inclusion and exclusion criteria were randomized to the treatment group (n=120 with compound loratadine capsule, 1 capsule q 24 h) or the control group (n=120 with loratadine tablet, 1 tablet q 12 h). All patients were given standard therapy. Results ① At the end of the treatment, in the compound loratadine group, 101 patients completed the study, and 19 patients withdrew. In the loratadine group, 103 patients completed the study, 17 patients withdrew. According to intention-to-treat analysis (ITT), the improvement rates of the treatment and control groups were 89.17% (107/120) and 88.33% (106/120) respectively. No significant difference was seen between the two groups (rank sum test, u=-1.8348, P>0.05). According to per-protocol analysis (PP), the improvement rates of the treatment and control groups were 96.04% (97/101) and 91.26% (94/103) respectively. No significant difference was seen between the two groups (rank sum test, u=-1.625 7, P>0.05). ② Adverse events were slight to moderate.The adverse event rates were 22.5% (27/120) and 21.67% (26/120) in the treatment and control groups respectively. No significant difference was seen between the two groups ( χ2 test, P>0.05). Conclusion Compound loratadine capsule is effective and safe for allergic rhinitis.

    Release date:2016-09-07 02:27 Export PDF Favorites Scan
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