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find Author "沈宏" 6 results
  • 亚甲基四氢叶酸还原酶基因C677T和A1298C位点多态性与胃癌易感性的相关性分析

    目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T和A1298C位点多态性与胃癌易感性的相关性。 方法回顾性收集2008年1月至2014年1月期间在笔者所在医院住院的、行MTHFR基因C677T和A1298C位点检测的160例胃癌患者作为胃癌组,收集同期160名自愿接受上述基因检测的健康体检人员作为对照组,比较2组2种位点基因型的分布情况。 结果胃癌组患者MTHFR基因C677T位点的基因型为:CC 72例,CT 64例,TT 24例;对照组为:CC 78例,CT 69例,TT 13例。胃癌组患者MTHFR基因A1298C位点的基因型为:AA 58例,AC 84例,CC 18例;对照组为:AA 62例,AC 77例,CC 21例。2组C677T位点及A1298C位点的基因型分布比较差异均无统计学意义(P>0.05)。 结论MTHFR基因C677T位点和A1298C位点多态性与胃癌的易感性无明显相关性。

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  • Clinical Study of Laparoscope Combined with Choledochoscope in Treatment of Patients with Cholecystolithiasis and Choledocholithiasis

    Objective To study the clinical effects of laparoscope combined with choledochoscope in patients with cholecystolithiasis and choledocholithiasis. Methods Clinical data of 74 patients with cholecystolithiasis and choledocholithiasis between Mar. 2009 and Feb. 2011 in our hospital were retrospectively analyzed. Among them, 37 cases underwent the laparoscope combined with choledochoscope operation (referred to as the double mirror operation group) and 37 cases underwent the conventional open operation (open operation group). The intraoperative conditions, therapeutic effect, and complications of patients in 2 groups were compared. Results The stone clearance rates of the two groups were 100%. The recurrence rate of 2 groups in the follow-up process was no significantly difference (P>0.05). In the double mirror operation group, the operative time was significantly longer than that open operation group (P<0.01);the intraoperative bleeding was significantly less than that open operation group (P<0.01);the anal exhaust time after operation, get out of bed time after operation, and total duration of hospitalization were significantly shorter than that open operation group (P<0.01);and the incidence of postoperative complications was significantly lower than that open oper-ation group(P<0.01). Conclusion Laparoscope combined with choledochoscope in treatment of cholecystolithiasis and choledocholithiasis patients has exact effects, with minor trauma, quicker recovery, and fewer complications, and it’s worthy of promotion.

    Release date:2016-09-08 10:35 Export PDF Favorites Scan
  • Short-Term Clinical Effect of Composite Digestive Enzyme Capsule in Treatment of Digestive Hypofunction after Cholecystectomy

    目的 探讨复合消化酶胶囊治疗胆囊切除术后消化功能减退症的临床疗效。方法 将84例胆囊切除术后出现消化功能减退的患者按住院日单双号原则分为对照组(n=41),给予抑酸药奥美拉唑肠溶胶囊与促胃肠道动力药多潘立酮片;观察组(n=43)加用复合消化酶胶囊。比较2组患者的临床疗效。结果 观察组显效14例,有效21例,好转7例,无效1例,总有效率为97.7%(42/43);对照组显效10例,有效15例,好转10例,无效6例,总有效率为85.4%(35/41)。观察组的临床疗效较优(P<0.05)。用药过程中均未发生不良反应。结论 复合消化酶胶囊对胆囊切除术后因胆汁分泌障碍而引起的消化功能减退症具有确切疗效。

    Release date:2016-09-08 10:34 Export PDF Favorites Scan
  • Clinical Effect of Gastric Bypass Surgery in Treatment for Patients with Type 2 Diabetes and Its Related Effect Factors

    目的探讨胃转流术治疗2型糖尿病的疗效及分析影响疗效的相关因素。 方法回顾性分析2009年1月至2012年7月期间我院收治的33例行胃转流术治疗的2型糖尿病患者的临床资料及随访情况。 结果33例患者治愈率为54.55%(18/33),总有效率为90.91%(30/33),无效3例。分析治愈及未治愈患者术前的临床资料发现,与未治愈患者比较,治愈患者的年龄更小、病程更短、2 h BG更低、BMI更大及空腹C肽更高(P<0.05)。 结论从本组有限资料的初步结果看,胃转流术治疗2型糖尿病临床效果确切,而对于低龄、病程短、BMI及空腹C肽较高和2 h BG较低的2型糖尿病患者可获得更好的治疗效果。

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  • Analysis of Association Between The Polymorphisms of DNA Repair Gene XRCC1 and Susceptibility to Colorectal Cancer

    目的探讨DNA损伤修复基因XRCC1 Arg194Trp位点多态性与结直肠癌易感性的关系。 方法选取120例结直肠癌患者与120例正常对照者进行对比研究。取外周血提取DNA,采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)技术对XRCC1 Arg194Trp基因多态性进行检测分析,比较不同基因型与结直肠癌易感性的关系。 结果2组观察对象在年龄、性别、吸烟、饮酒、饮食特点等常见暴露因素方面的差异均无统计学意义(P>0.05),变异基因型Arg/Trp+Trp/Trp出现频率在2组观察对象中分别为30.00%和24.17%,差异无统计学意义(P>0.05)。 结论XRCC1 Arg194Trp位点多态性与结直肠癌的易感性并无显著相关性。

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  • Atypical Adrenal Phaeochromocytoma: A Retrospective Clinical Study

    Objective To retrospectively analyze the clinical information of a series of patients with atypical adrenal phaeochromocytoma in order to improve the diagnosis of atypical phaeochromocytoma. Methods Ninety patients diagnosed pathologically as adrenal phaeochromocytoma from January 1998 to December 2004 in the Affiliated Hospital of Inner Mongolia Medical College were included in the study. Patients with phaeochromocytoma were classified into the typical group and atypical group based on their clinical manifestations. The differences were analyzed between the two groups in terms of patient age, tumor location and maximal diameter, incidence of hypertension, and plasma catecholamine level. Results About 24.4% (22/90) of the patients with phaeochromocytoma were classified as atypical. There was no significant difference in the maximal tumor diameter between the two groups. The plasma norepinephrine level of the atypical group was significantly lower than that of the typical group (P=0.001), and the positive rate of plasma norepinephrine of the atypical group was also lower than that of the typical group (P=0.003). Conclusion  Compared with typical phaeochromocytoma, atypical phaeochromocytoma is associated with a lower plasma norepinephrine level. The size of adrenal tumor cannot contribute to the diagnosis of atypical phaeochromocytoma. Based on atypical manifestations, CT examination results, and plasma catecholamine level, most atypical phaeochromocytoma should be diagnosed correctly.

    Release date:2016-08-25 03:36 Export PDF Favorites Scan
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