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find Author "洪桢" 9 results
  • 后疫情时代远程教育提升癫痫诊治水平的实践与思考

    自新型冠状病毒肺炎(Corona virus disease 2019,COVID-19)疫情爆发以来,癫痫患者的身心健康受到了不同程度的影响。在后疫情时代,进一步提高癫痫诊治水平的重要性不言而喻。在疫情防控形势仍然严峻的当下,远程教育凭借其开放性、延伸性、灵活性、管理性等特点成为这一特殊时期医学教育的重要途径。本文就后疫情时代远程教育提升癫痫诊治水平的实践进行探讨,并对未来远程教育的发展予以思考。

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  • Feasibility and acceptability of smart phone applications for seizure management in China: questionnaire study among patients with epilepsy and children and adolescents' caregivers

    ObjectiveTo determine the feasibility as well as the attitudes among caregivers of children and adolescents with epilepsy and adult patients with epilepsy in China towards the use of smart phone applications (apps) for the management of seizures. MethodsThe caregivers of children and adolescents with epilepsy, ages ranging from 0 to 17 years old and adult patients who were more than 18 years old, were enrolled in the study from the Epilepsy Prevention and Cure Center of West China Hospital within the time period from June to December 2015. A questionnaire gauging the attitudes towards using apps for seizure management was administered to the 502 epilepsy patients and 390 caregivers of children and adolescents with epilepsy. ResultsAmong adult patients, they were more likely to use an app in those who were young, lived in cities, had higher education, had a stable employment and had frequent seizures (P=0.002, P<0.001, P=0.001, P<0.001, P=0.01). Among caregivers of children and adolescents with epilepsy, participants were more likely to use an app in those who were male (P=0.03), had a higher education level, a higher annual household income as well as stable job (P<0.001, P<0.001, P=0.02). ConclusionThe results of this study imply a favorable attitude towards the use of apps for seizure management among adult patients and caregivers of children and adolescents with epilepsy. The use of such apps in China represents a promising strategy among caregivers for seizure management.

    Release date:2016-11-28 01:27 Export PDF Favorites Scan
  • Aetiology of convulsive status epilepticus in adults

    ObjectiveTo investigate the etiology of patients with convulsive status epilepticus (CSE).MethodsBy taking epilepsy, seizure, status epilepticus, and epileptic seizure as keywords, the clinical data of epilepsy patients hospitalized in the First People’s Hospital of Longquanyi District of Chengdu and the People’s Hospital of Leshan from January, 2012 to December, 2017 were retrospectively collected from a retrieval system for electronic patient records. The collected CSE cases were screened by trained epilepsy specialists in strict accordance with inclusion criteria and exclusion criteria. The etiology of CSE, and the pathogenetic distinctions among patients with different ages, sexes, educational levels, places of residence, and histories of epilepsy were analyzed based on medical histories and accessory examinations. The prognostic factors for epilepsy were determined using logistic regression analysis.ResultsIn this study, a total of 852 hospitalized epilepsy cases were retrieved, among which 104 cases were CSE cases aged between 18 and 86, including 75 males and 29 females. There were 13 CSE deaths (12.5%). There were significant differences in the pathogeneses among CSE patients with different ages and histories of epilepsy (χ2=52.396, 18.354; P<0.05). However, no significant difference in CSE pathogeneses was observed among patients with different sexes, educational levels, or places of residence (P>0.05). Drug withdrawal or dose reduction was the leading cause of CSE in patients with a history of epilepsy (n=28, 57.1%), while cerebrovascular diseases (n=19, 34.5%) were common causes among those without a history. Among patients aged over 65, cerebrovascular diseases (n=17, 43.6%) were determined as the major causes of CSE, while for those aged under 65, drug withdrawal or dose reduction was the main pathogeny (n=20, 30.8%). Results obtained from multivariate logistic regression analysis on the prognostic factors for epilepsy showed that the duration of epileptic seizure significantly influenced the prognosis of patients [odds ratio=1.299, 95% confidence interval (1.074, 1.571), P=0.007], while there were no significant correlations between other factors and epilepsy prognosis (P>0.05).ConclusionsCerebrovascular diseases are the leading causes of geriatric CSE. Irregular medication of epilepsy patients is a prominent avoidable trigger for CSE.

    Release date:2019-04-22 04:14 Export PDF Favorites Scan
  • 解读 ILAE 关于“继发于自身免疫性脑炎的急性症状性痫性发作和自身免疫相关性癫痫”最新概念

    Release date:2021-01-07 02:57 Export PDF Favorites Scan
  • 国际专家组副肿瘤性神经综合征新诊断标准解读

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  • Progress in the study of correlation between gut microbes and epilepsy and its clinical application

    The correlation between gut microbes and epilepsy is a hot research topic. This review aims to summarize the effects of Ketogenic diet (KD) on gut microbes and the preclinical and clinical progress of the use of Fecal microbiota transplants (FMT) and Probiotics in the intervention of epilepsy to provide clinical reference. Gut microbes mediates the antiepileptic effect of KD. Many studies have found that bactericides decreased in epileptic patients, and KD can increase bactericides abundance, which may be one of its effective mechanisms. Both FMT and probiotics showed antiepileptic effects on epileptic model mice with different pathogenesis, suggesting that gut microbes is an important target for epilepsy treatment. Preliminary clinical studies of small samples suggest that the use of probiotics can effectively treat refractory epilepsy and autoimmune-associated epilepsy, and can improve comorbidities. No serious and long-term side effects of probiotics have been found in epileptic patients. In the future, more high-quality studies are needed to further clarify its efficacy and mechanisms, which could lead to new strategies for epilepsy treatment and refresh our understanding of the causes of epilepsy.

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  • 以头痛为首发症状的富亮氨酸胶质瘤失活 1 蛋白抗体阳性边缘性脑炎一例

    Release date:2017-12-25 06:02 Export PDF Favorites Scan
  • 探讨在癫痫专业研究生培养中开展思想政治教育的方法

    研究生教育中,开展思想政治教育具有极其重要的作用。研究生不光要有创新能力,其价值取向和现实追求更要与坚持教育为人民服务、为中国共产党治国理政服务、为巩固和发展中国特色社会主义制度服务、为改革开放和社会主义现代化建设服务紧密联系起来。癫痫专业是神经病学中一个重要组成部分,研究生众多,我国的癫痫事业还需要研究生的继承和发展。本文就现有的思政教育和思政课程的现状,结合其他专业的先进案例,探讨癫痫专业的思政教育的切入点和可行办法,旨在进一步推动思政教育在癫痫专业的贯彻落实,实现优秀癫痫专业人才的培养,最终推动癫痫学科的快速发展与进步。

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  • Diagnosis status and epidemiological characteristics of Anti-N-methyl-D-aspartate receptor encephalitis in Sichuan province

    ObjectiveTo analyze the diagnosis status and epidemiological characteristics of anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis) in the Sichuan province of China. MethodsIn the retrospective survey study, data of cases suspected as autoimmune encephalitis in Sichuan province from January 2012 to February 2017 were collected from the third-party test center.The diagnosis status and epidemiological characteristics of anti-NMDAR encephalitis were analyzed. Results① A total of 1 714 cases had been suspected as autoimmune encephalitis with anti NMDA receptor antibodies tested.In hospitals of capital city, cerebrospinal fluid or serum of 1 511 cases were tested since 2012.In other cities, 203 cases were tested since 2014.Hospitals with anti NMDA receptor antibodies tested increased by year.The cases distributed in the department of neurology, psychology, pychiatric, ICU, pediatrics, geriatrics, otolaryngology, infection, the mergency department and pneumology.② Cases with anti NMDA receptor antibodies tested increased by year.A total of 155 cases were confirmed as anti-NMDAR encephalitis, with the average onset age of (27.9±12.0) years ranged from 9 years to 77 years, including 89 women and 66 male.The female average age were (26.5±11.31) years, while the male were(29.0±13.0) years.③ Among the 155 confirmed cases, 127 cases with detailed clinical data were analyzed further.Seizure and behavior disorder were the main symptoms at onset.Among the 127 cases, 107 cases were misdiagnosed at their first hospital visit, with the misdiagnose rate of 84.3%.18 cases were reported with tumors (17 female), mainly with teratoma(11/17). ConclusionIn Sichuan province, the doctors of hospitals in non-capital city should strengthen the identification of autoimmune encephalitis.Anti-NMDAR encephalitis could be misdiagnosed easily and non-neurological physicians should also take attention;

    Release date:2017-09-26 05:09 Export PDF Favorites Scan
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