【摘要】 目的 探讨深吸气量（inspiratory capacity，IC）与慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者临床特征的相关性。 方法 2009年12月-2010年6月纳入84例稳定期COPD患者，测定6分钟步行试验（6-minute walk test，6MWT）、圣乔治生活问卷评分（St George′s respiratory questionnaire，SGRQ）及肺功能检查:第1秒用力呼气容积（forced expirotovy volume in one second，FEV1）、IC、IC与肺总量（total lung capacity，TLC）比值（IC/TLC）等相关指标，并进行相关性分析。 结果 6MWT值与FEV1无明显直线相关（r=0.14，Pgt;0.1）；6MWT值与FEV1≥60%无明显直线相关（r=0.16，Pgt;0.1）；6MWT值与IC值呈正的直线相关（r=0.317，Plt;0.01）；6MWT值与IC/TLC值呈正的直线相关（r=0.274，Plt;0.01）；SGRQ值与FEV1呈负的直线相关（r=-0.307，Plt;0.01）；SGRQ值与IC值无直线相关（r=-0.001，Pgt;0.25）；SGRQ值与IC/TLC值无直线相关（r=-0.003，Pgt;0.25）。 结论 对COPD患者，IC比FEV1更准确地反映患者的运动耐量的程度，FEV1比IC更准确地反映患者呼吸困难的严重程度。【Abstract】 Objective To explore the relationship between the inspiratory capacity (IC) and clinical characters of stable chronic obstructive pulmonary disease (COPD). Methods Between December 2009 and June 2010, 84 patients with stable COPD were enrolled. Lung function (FEV1, IC, IC/TLC) ,6 minute walk-test (6MWT) and St George′s respiratory questionnaire (SGRQ) were examined. The relationship among FEV1, IC, IC/TLC, and the results of 6MWT and SGRQ by Pearson correlation analysis. Results There was no linear correlation between 6MWT and FEV1 （r=0.14，Pgt;0.1）, and 6MWT and FEV1≥60% （r=0.16，Pgt;0.1）. There was positive correlation between 6MWT and IC （r=0.317，Plt;0.01）, and 6MWT and IC/TLC （r=0.274，Plt;0.01）. There was negative correlation between SGRQ and FEV1 （r=-0.307，Plt;0.01）; and no linear correlation between SGRQ and IC （r=-0.001，Pgt;0.25）, and SGRQ and IC/TLC （r=-0.003，Pgt;0.25）. Conclusion In stable COPD patients, IC may be more accurate than FEV1 in refection of exercise tolerance while FEV1 may be more sensitive than IC in evaluation of dyspnea.
Objective To study the predictive value of inspiratory capacity (IC) and total lung capacity (TLC) on acute exacerbation of patients with chronic obstructive pulmonary disease (COPD). Methods The in-patients due to acute exacerbation of COPD (AECOPD) from February 2017 to March 2019 were recruited in the study. Research data were collected during the recovery period and one year follow-up , and the patients were divided into two groups according to whether there was another acute exacerbation. Results A total of 372 patients were included in the study. In the patients with acute exacerbation, the age and TLC as a percentage of the expected value (TLC%pred) were higher, while IC as a percentage of the expected value (IC%pred) and the ratio of IC and TLC (IC/TLC) were lower. Univariate analysis revealed that IC/TLC≤25% was a significant predictor of acute exacerbation (P<0.001) after the AECOPD patients were discharged. Multivariable analysis revealed age (OR=1.25, 95%CI 1.17 to 1.44, P<0.001) and IC/TLC≤25% (OR=1.68, 95%CI 1.36 to 2.07, P<0.001) were independent risk factors of AECOPD.Conclusions Decreased IC/TLC significantly correlates with poor prognosis of COPD. IC/TLC≤25% is an independent risk factor for acute exacerbation.