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find Author "王建民" 9 results
  • Meta-Analysis of Gastrodine Injection for Vertebrobasilar Insufficiency

    【摘要】 目的 研究天麻素注射液治疗椎-基底动脉供血不足(vertebrobasilar insufficiency,VBI)的疗效和安全性。 方法 检索CBM、CNKI、VIP、万方数据库,检索时间为各数据库建库至2010年5月,纳入天麻素注射液对比其他药物治疗VBI的随机对照试验(RCT),对纳入研究进行方法学质量评价后,采用RevMan 5.0软件进行Meta分析。 结果 纳入8个RCT,涉及受试者648例,均为C级文献,Meta分析结果显示:天麻素注射液对比丹参注射液治疗VBI,显效率和总有效率差异均有统计学意义[RR=1.63,95%CI (1.37,1.95)和RR=1.21,95%CI (1.12,1.30)]。 结论 基于当前证据,临床治疗VBI,天麻素注射液疗效优于丹参注射液,且安全性较好。【Abstract】 Objective To study the effectiveness and safety of gastrodine injection for vertebrobasilar insufficiency (VBI). Methods Databases of CBM, CNKI, VIP and Wanfang were searched from the time of the establishment till May 2010 and randomized controlled trials (RCT) of gastrodine injection compared with other positive drugs for VBI were included. Quality evaluation and meta-analysis by using RevMan 5.0 were performed. Results A total of 8 grade-C RCTs including 648 cases were gathered. The results of meta-analysis showed that the difference of excellent and effective rates between danshen injection and gastrodine injection for VBI were significant: RR=1.63, 95%CI (1.37, 1.95) and RR=1.21, 95%CI (1.12, 1.30). Conclusion Based on current evidence, compared with danshen injection, gastrodine injection is better and safer for VBI.

    Release date:2016-09-08 09:24 Export PDF Favorites Scan
  • Unstable Angina Pectoris Treated by Puerarin Injection Combined with Low Molecular Weight Heparins: A Meta-Analysis

    【摘要】 目的 评价葛根素注射液(PI)联合低分子肝素(LMWH)治疗不稳定型心绞痛(UAP)的疗效和安全性。 方法 计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP-维普)、万方-数字化期刊全文库,纳入在常规治疗上加用PI和LMWH对比单纯常规治疗的随机对照试验(RCT),对纳入研究进行质量评价和Meta分析。 结果 共纳入21个RCT,均为C级文献。Meta分析结果显示,在临床症状疗效显效率、心电图疗效显效率和有效率指标方面,两组差异有统计学意义:RR(95%CI)分别为:1.63(1.48,1.79)、1.57(1.34,1.83)及1.28(1.10,1.49)。 结论 基于上述证据,在常规治疗UAP上加用PI和LMWH疗效优于常规治疗。【Abstract】 Objective To evaluate the effect of the puerarin injection (PI) combined with low molecular weight heparins (LMWH) on unstable angina pectoris (UAP). Methods Randomized controlled trials (RCT) of PI combined with LMWH treating UAP were gathered from CBM, CNKI, VIP, and Wanfang data bases; and study quality was evaluated and the Meta-analysis was carried out. Results A total of 21 RCT were identified, of which all were in graded C. According to Meta-analysis, the differences of the clinic excellent rate, electrocardiogram excellent rate and effective rate between the two groups were significant; the RR (95%CI) were: 1.63 (1.48, 1.79), 1.57 (1.34, 1.83), and 1.28 (1.10, 1.49). Conclusion Based on the evidence recently, PI and LMWH adding is better than ordinary treatment for UAP.

    Release date:2016-09-08 09:51 Export PDF Favorites Scan
  • 背阔肌肌皮瓣结合外固定器治疗严重胫腓骨开放性骨折并软组织缺损

    Release date:2016-09-01 09:35 Export PDF Favorites Scan
  • Efficacy and Safety of Nickel-titanium Shape Memoryalloy Compression Anastomosis Clip for Gastrointestinal Anastomosis: A Meta-Analysis

    ObjectiveTo systematically review the efficacy and safety of nickel-titanium shape memory alloy compression anastomosis clip (Ni-Ti CAC) for gastrointestinal anastomosis. MethodsThe Cochrane Library, PubMed, Web of Knowledge and CBM databases were searched for the randomized controlled trials (RCTs) that investigated the efficacy and safety of Ni-Ti CAC versus surgical stapler for gastrointestinal anastomosis. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data and evaluated the methodological quality of the included studies. Then meta-analysis was performed using RevMan 5.2. ResultsEight RCTs involving 457 patients were included in the meta-analysis. The results of meta-analysis showed that, compared with the surgical stapler group, the Ni-Ti CAC group was superior in operation time (MD=-8.30, 95%CI-15.58 to-1.02, P=0.03), food intake (MD=-0.37, 95%CI-0.70 to-0.03, P=0.03), bowel movement (MD=-1.13, 95%CI-1.67 to-0.59, P < 0.000 1), passing gas time (MD=-0.30, 95%CI-0.55 to-0.06, P=0.01), and length of hospital stay (MD=-1.04, 95%CI-1.35 to-0.74, P < 0.000 01), with significant differences. No significant difference was found in anastomosis time (MD=-1.84, 95%CI-3.91 to 0.22, P=0.08). As for safety, no significant difference was found in anastomosis-related complications between both groups. ConclusionCurrent evidence shows that Ni-Ti CAC achieves better efficacy and safety in gastrointestinal anastomosis compared with surgical stapler.

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  • 葡萄膜炎所致眼底病变的超广角眼底成像检查应用研究现状

    超广角眼底成像技术可在正常瞳孔状态下单次扫描获得200°范围内的眼底彩色、血管造影和自身荧光图像, 有助于发现既往其他眼底影像检查手段不能发现的周边部眼底病变, 获得更加丰富的葡萄膜炎及其所致眼底病变信息。在此基础上对这些新的发现和信息进行合理分析解释, 必将改变葡萄膜炎及其所致眼底病变的认知和干预水平现状, 推动葡萄膜炎及其所致眼底病变临床、科研水平的提高。

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  • 玻璃体腔注射曲安奈德治疗非动脉炎性前部缺血性视神经病变的临床观察

    Release date:2016-09-02 05:37 Export PDF Favorites Scan
  • Bioabsorbable versus Metal Interference Srews for Endoscopic Restruction of Anterior Cruciate Ligament: A Meta-analysis of Randomized Controlled Trials

    Objective To compare clinical outcome of bioabsorbable interference screws (BS) with metal Interference screws (MS) for restruction of anterior cruciate ligament (ACL). Methods The electronic databases (PubMed, EMbase, Cochrane Central Register of Controlled Trials, CBM, CNKI, and VIP) were searched in order to retrieve randomized controlled trials (RCTs) about comparing BS with MS for restruction of ACL. In addition, reference lists from original studies and review articles were handsearched. The Jadad’s scale and Cochrane collaboration’s RevMan 5.0 software were used for assessing trial methodological quality and data analyses. Results Eleven RCTs were included. There were 935 participants that met inclusion criteria in all studies. Results of Meta-analyses showed the MS group had a higher Lysholm score. However, no significant differences were found in Lanchman Test, IKDC Data and KT1000 result between patients treated by BS and by MS. Conclusion Bioabsorbable interference screws provide equivalent clinical outcomescompared with metal interference screws. However, further confirmation is required because of varieties of types and complex compositions.

    Release date:2016-09-07 11:23 Export PDF Favorites Scan
  • 前部缺血性视神经病变荧光素眼底血管造影的局限性

    Release date:2016-09-02 06:05 Export PDF Favorites Scan
  • A Meta-analysis of Tissue Engineered Skin Improved Wound Closure in Diabetic Foot Ulcers

    Objective To systematically analyze the randomized controlled trials that compare tissue-engineered skin (TES) with conventional treatment for chronic diabetic foot ulcer (DFU) in terms of effectiveness and utilization.Methods We searched the electronic databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, CBMWeb, CNKI, and VIP) in order to compare the efficiency and safety between TES and conventional treatment (CT) in the patients with DFU. In addition, we manually searched reference lists from original studies and review articles.Results Seven trials were included, which were all randomized controlled trials and had a duration of DFU over 6 weeks. There were 880 participants that met inclusion criteria in all studies, and all patients underwent pre-treatment procedures and were treated by TES (human skin equivalents, living skin equivalents or bioengineered skin, such as Graftskin, Dermagraft and Graftjacket) for 12 weeks. All trials had two groups: the treatment group and the control group, but the two trials divided the treatment groups into 3 different dosages and 2 different ulcer allocation subgroups, respectively. Meta-analysis results showed significant differences in the rate of complete wound closure (Plt;0.0001, 95%CI 0.08 to 0.20) and in the occurrence of complications and severe adverse events (P=0.008, 95%CI – 0.06 to – 0.01) between TES treated patients and conventionally treated patients. Conclusion The review shows TES improves completed closure of DFU compared with CT, and it is more effective in reducing side effects.

    Release date:2016-09-07 02:09 Export PDF Favorites Scan
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