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find Author "王明钊" 3 results
  • Clinical Study of Vascular Endothelial Growth Factor-C and Cytokeratin 19 in StageⅠNon-small Cell Lung Cancer Patients

    Abstract: Objective To evaluate the significance of expression of vascular endothelial growth factor-C (VEGF-C) and cytokeratin 19 (CK19) in patients with stage I non-small cell lung cancer (NSCLC). Methods A total of 269 patients with NSCLC who underwent standard lobectomy and lymph node dissection by the same surgical team in our hospital from January 2004 to June 2005 were included in this study. All the clinical data and follow-up results were complete, and all the pathological specimens were well kept. No preoperative or postoperative adjuvant therapy such as radiotherapy and chemotherapy was administered to those patients. Expressions of VEGF-C in cancer tissues was detected by immunohistochemical streptavidin-peroxidase (S-P) method, and CK19 was marked to examine micrometastasis in hilar and mediastinal lymph nodes. Clinical outcomes, pathological results and follow-up data were analyzed in combination with VEGF-C and CK19 expression. Results VEGF-C expression was not statistically different between different category in sex(Hc=1.722,P=0.084), age (Hc=0.914,P=0.360), smoking (Hc=2.440,P=0.295), pathology type (Hc=5.668,P=0.058)or tumor size (Hc=0.165,P=0.920) . VEGF-C expression was statistically different between different groups of pathological differentiation (Hc=29.178,P=0.000). CK19 expression was not statistically different between different category in sex(χ2=0.000,P=0.999), age (χ2=0.005,P=0.999), smoking (χ2=2.294,P=0.317), pathology type (χ2=0.573,P=0.289), tumor size(χ2=0.006,P=0.999), and pathological differentiation (χ2=2.927,P=0.231). Five-year survival rate was statistically different between different grade of VEGF-C expression (χ2=37.318,P=0.000), and was also statistically different between positive group and negative group of CK19 (χ2=39.987,P=0.000). There was statistical difference between different grade of VEGF-C expression and positive rate of CK19 (χ2=25.954,P=0.000). Conclusion Expression of VEGF-C and CK19 is closely related to postoperative 5-year survival of patients with stage I NSCLC. Detection of VEGF-C and CK19 is of great clinical significance as it is helpful to predict patient prognosis and choose proper postoperative adjuvant therapy.

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
  • Diagnosis and Management of Concealed Intrathoracic Anastomotic Leak of Esophagus

    Abstract: Objective To investigate diagnosis and treatment of concealed intrathoracic anastomotic leak of the esophagus. Methods We retrospectively analyzed the clinical data of 32 patients who presented with unexplained sepsis (temperature>38 ℃ and elevated white blood cell count) after esophagectomy and intrathoracic anastomosis for esophageal carcinoma or gastric cardia carcinoma in Affiliated Hospital, Medical College of Qingdao University from January 2006 to December 2010. All the patients underwent oral water-soluble contrast esophagogram and oral water-soluble contrast computerized tomography of the chest. None of the patients had any sign of contrast leak in these diagnostic examinations, but their chest computerized tomography all showed peri-anastomotic bubble and encapsulated effusion. Fifteen patients were treated as concealed intrathoracic anastomotic leak of the esophagus, including fasting, broad spectrum antibiotic treatment, prolonged gastrointestinal decompression and enteral nutrition via naso-intestinal feeding tube. The other 17 patients were not treated as anastomotic leak of the esophagus and only received broad spectrum antibiotic treatment. Results None of the 15 patients who were treated as concealed intrathoracic anastomotic leak finally developed anastomotic leak proved by oral water-soluble contrast esophagogram and computerized tomography of the chest (0%, 0/15). Among the 17 patients who were not treated as anastomotic leak, fourteen patients developed anastomotic leak later (82.4%, 14/17), 2 patients died of aorto-esophageal fistula and 3 patients died of multiple organ dysfunction syndrome. Conclusion Peri-anastomotic bubble and irregular encapsulated effusion in oral water-soluble contrast esophagogram and computerized tomography of the chest should be considered as specific signs of concealed intrathoracic anastomotic leak of esophagus after esophagectomy and intrathoracic anastomosis. Patients with such signs should be treated as anastomotic leak.

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
  • 下行性坏死性纵隔炎的诊断与治疗

    目的 探讨下行性坏死性纵隔炎(DNM)的诊断和治疗方法。 方法 回顾性分析1988年1月至2009年12月青岛大学医学院附属医院收治11例DNM患者的临床资料,其中男8例,女3例;年龄25~71 (55±3)岁。早期收治的患者外科治疗采用颈部清创、引流,或经颈部纵隔引流;后期收治的患者采用颈、胸部同期清创、引流及术后冲洗。 结果 行单纯颈部清创、引流及经颈部纵隔引流的7例患者中死亡4例,均死于严重纵隔感染导致多器官功能衰竭,3例生存患者均为感染尚未侵犯下纵隔和胸腔;行颈、胸部清创、引流和冲洗的4例患者全部治愈。随访7例,随访时间3个月,患者恢复良好。 结论 DNM病情凶险,一旦发病迅速进展为脓毒血症,甚至死亡。重视口咽部和颈部感染患者的胸部症状、体征变化,及时行胸部CT检查是尽早诊断DNM的关键。尽早进行颈、胸部彻底清创、充分引流及有效冲洗是治疗DNM成功的关键。

    Release date:2016-08-30 05:50 Export PDF Favorites Scan
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