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find Author "王欣" 36 results
  • 肿瘤医院护理人员手卫生认知及执行状况调查

    目的了解肿瘤医院护理人员手卫生认知及执行状况,为控制医院感染、制订预防措施提供有效依据。 方法2011年5月-7月,采用横断面调查法,对肿瘤医院的23个科室中528名护理人员进行问卷调查,调查护理人员手卫生认知及执行情况。 结果绝大多数护理人员对手卫生指征具有正确的认识,问卷的正确回答率(正答率)较高。护理人员手卫生知识认知情况正答率不足90%的项目有8项。47.85%的护理人员日消毒或洗手次数为10~20次。“工作太忙”为手卫生执行效果不佳的主要原因。 结论肿瘤医院护理工作人员手卫生知识认知和手卫生执行率还有待加强。

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  • Advances of Mechanism of the Atrial Remodeling in Atrial Fibrillation

    Atrial fibrillation(AF) is the most common disorder of cardiac rhythm. It has a high morbidity, mortality and disability, and serious impact on quality of life of patients. It is demonstrated that atrial remodeling which includes atrial electrical remodeling and structural remodeling,are the central contributors to the development and selfperpetuating of AF. However, The mechanisms that underlie the atrial remodeling process in AF have not yet been completely elucidated. New strategies for the prevention and termination of AF should build on our knowledge of the mechanisms of atrial remodeling. Medication for the reversal of atrial remodeling may be the new target for the treatment of AF. At present, drugs that target atrial remodeling have already obtained fruitful results in the experimental and clinical investigations. Now some recent advancements of this area is reviewed in this article.

    Release date:2016-08-30 06:05 Export PDF Favorites Scan
  • Influence of Atrial Fibrosis on the Efficacy of Radiofrequency Maze Procedure in Patients with Rheumatic Heart Disease and Permanent Atrial Fibrillation

    Abstract: Objectives To determine the atrial expression of the collagen Ⅰ, collagen Ⅲ and the transforming growth factorbeta 1 (TGF-β1) in patients with rheumatic heart disease (RHD) and permanent atrial fibrillation(PAF) and to investigate the relationship between the extent of atrial fibrosis and the effectiveness of radiofrequency maze procedure in patients with RHD and PAF. Methods A total of 40 patients with RHD and PAF (≥6 months) who underwent a radiofrequency maze procedure with concomitant valvular surgery were collected for the experimental group. We acquired 100 mg of the left auricle tissue in each patient and followed up these patients after 3, 6 months of [CM(158mm]surgery. Then we assigned these patients to nonAF group and persistent AF group according to the results of the 6month followup. Another 10 patients with RHD and sinus rhythm(SR) who underwent valvular surgery alone were assigned to SR group and their left auricle tissue was also obtained. In order to determine the extent of atrial fibrosis, we observed the amount of collagen volume fraction Ⅰ,Ⅲ(CVF-Ⅰ,CVF-Ⅲ) by semiquantitative analysis with picrosirius red staining method. Using the β actin protein as the endogenous reference gene, we detected the expressions of TGF-β1 mRNA by semiquantitative reverse transcriptionpolymerase chain reaction(RT-PCR) technique. Results Each group has the same clinical baseline. At 6month follow-up, 28 among the 40 patients were categorized into the nonAF group and 12 into the AF group. (1) Patients in the nonAF group and the AF group had higher mRNA expressions of TGF-β1, CVF-Ⅰ and CVF-Ⅰ/CVF-Ⅲ compared with the SR group (F=6.487, P=0.003; F=3.711, P=0.032; F=3.697, P=0.032). The AF group had higher mRNA expressions of TGF-β1, CVF-Ⅰ and CVF-Ⅰ/CVF-Ⅲ than the nonAF group (t=4.372, P=0.043; t=4.603, P=0.038; t=4.776, P=0.035). But the CVFⅢ had no significant differences among the three groups (P>0.05). (2) The patients whose left atrial function recovered after Maze procedure had lower mRNA expression than those patients whose left atrial function did not recover in the nonAF group (t=5.570, P=0.027). (3) The TGF-β1 mRNA expression has a positive correlation with both the contents of CVF-Ⅰ and left atrial diameter (r=0.786, Plt;0.05; r=0.858, Plt;0.05). Multiple logistic regression analysis revealed that the mRNA expression levels of TGF-β1, CVF-Ⅰ and left atrial diameter were independently associated with the postoperative persistence of atrial fibrillation. Conclusion The extent of atrial fibrosis in patients with RHD and PAF may be related to the sinus rhythm restoration and maintenance after AF surgical radiofrequency ablation and the resumption of atrial function.

    Release date:2016-08-30 06:02 Export PDF Favorites Scan
  • Modified Aortic and Pulmonic Translocation in Management of Transposition of Great Arteries with Ventricular Septal Defect and Left Ventricular Outflow Tract Obstruction

    Abstract: Objective To investigate the clinical application of a novel modified aortic and pulmonic translocation in surgical repair of transposition of great arteries(TGA) with ventricular septal defect(VSD) and left ventricular outflow tract obstruction(LVOTO). Methods Five patients received surgical repair of the TGA with VSD and LVOTO at our heart center. The surgical technique used was a modification of the Nikaidoh procedure by which the native pulmonary root was preserved and translocated to reconstruct the right ventricular outflow tract. Two patients with atrioventricular discordance required a Senning procedure. Results All patients survived the operation and were discharged from the hospital. There were no major complications. At a median follow-up of 5.40 months, the echocardiography demonstrated normal ventricular function in all patients. No residual aortic stenosis or insufficiency was found in all the patients. Two patients had mild pulmonary insufficiency. Conclusions The novel modification of the Nikaidoh procedure may have excellent early results with minimal postoperative pulmonary insufficiency. The procedure may also allow growth of the pulmonary root and therefore decrease the need for reoperation. However, this has to be further investigated and long-term follow-up studies are warranted.

    Release date:2016-08-30 06:13 Export PDF Favorites Scan
  • 风湿性心脏病心瓣膜置换患者术前免疫功能的变化

    目的 了解风湿性心脏病心瓣膜置换术患者术前免疫功能的变化.方法 将52例心瓣膜置换术患者作为心瓣膜置换术组,50例健康人作对照组.术前分别抽取空腹静脉血测定植物血凝素淋巴细胞转化率、淋巴细胞分化群分子3阳性T细胞(CD3+)、淋巴细胞分化群分子4阳性T细胞(CD4+)、淋巴细胞分化群分子8阳性T细胞(CD8+)、中性粒细胞吞噬率和杀伤率、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、免疫球蛋白E(IgE)、补体3(C3)、补体4(C4)和循环免疫复合物(CIC).结果 心瓣膜置换术组术前的细胞免疫指标及IgE,C4均明显低于对照组(P<0.05或P<0.01),心瓣膜置换术组IgG,IgA,C3和CIC明显高于对照组(P<0.05或P<0.01).IgE与CD4+呈相关关系(r=-0.314,P<0.05),C3与植物血凝素淋巴细胞转化率和中性粒细胞杀伤率呈相关关系(r=0.311和r=0.300,P<0.05);CIC与CD3+,CD4+和CD8+呈相关关系(r=0.422,r=0.311和r=0.391;P<0.01,P<0.05和P<0.01).结论 风湿性心脏病心瓣膜置换患者术前的免疫功能与正常人有明显差异,患者处于易感染状态,心外科医师应采取有效措施预防和治疗患者术前可能发生的感染.

    Release date:2016-08-30 06:35 Export PDF Favorites Scan
  • 同指带蒂筋膜瓣修复甲床及指背皮肤软组织缺损

    Release date:2016-09-01 09:30 Export PDF Favorites Scan
  • RECONSTRUCTION OF ANTERIOR CRUCIATE L IGAMENT BY FREE AUTOGRAFT OF MIDDL E ONE THIRD OF BONE- PATEL L AR TENDON- BONE COMPL EX

    OBJECTIVE To investigate the outcome of anterior cruciate ligament (ACL) by free autograft of middle one third of bone-patellar tendon-bone complex which was formed by lower edge of patella, middle one third of patellar tendon, and tibial tubercle. METHODS From April 1994 to August 1996, ACL reconstruction by bone-patellar tendon-bone complex was performed in 8 patients with ACL injury. RESULTS All cases were followed up 5 months to 3 years, averaged 26 months, excellent results were obtained in 4 cases, better in 3 cases and moderate in 1 case. The Lanchman test and/or anterior drawer test were positive in 8 cases preoperatively and only 1 case was positive postoperatively. Instability existed in 5 cases preoperatively were disappeared after operation. All patients could basically meet the demands of daily life. CONCLUSION Reconstruction of ACL by free autograft of middle one third of bone-patellar tendon-bone complex is an effective method for the restoration of stability in knee joint.

    Release date:2016-09-01 10:26 Export PDF Favorites Scan
  • Effectiveness of Yindan Xinnaotong capsule in the treatment of cardiovascular and cerebrovascular diseases: a meta-analysis

    Objective To systematically review the effectiveness of Yindan Xinnaotong capsule for cardiovascular and cerebrovascular diseases. Methods We electronically searched databases including PubMed, MEDLINE, CBM, CNKI, VIP, WanFang Data for published articles of randomized controlled trials (RCTs) of Yindan Xinnaotong capsule plus conventional drugs versus conventional drugs for cardiovascular and cerebrovascular diseases from inception to April, 2016. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 62 RCTs involving 6 306 patients with cardiovascular and cerebrovascular diseases were included. The results of meta-analysis showed that the improvement of symptoms, such as the total clinical effective rate of cerebrovascular disease indications (stroke) (RR=1.25, 95% CI 1.19 to 1.31,P<0.000 01), and the total clinical effective rate of cerebrovascular disease (ischemic headache) indications (RR=1.27, 95% CI 1.17 to 1.38,P<0.000 01), and the total clinical effective rate of coronary heart disease and angina pectoris (RR=1.21, 95% CI 1.17 to 1.25,P<0.000 01), were superior in the combination arm to the conventional drugs alone arm. Conclusion The current evidence shows that the combination of Yindan Xinnaotong capsule and conventional drugs may significantly improve the effectiveness. Due to the limited quality and quantity of the included studies, the above conclusions need more high quality studies to verify.

    Release date:2017-04-24 03:30 Export PDF Favorites Scan
  • Concomitant repair of moderate or less tricuspid regurgitation during mitral valve surgery improves early and mid-term prognosis of tricuspid valve and right heart function

    ObjectiveTo investigate the effect of concomitant tricuspid valve repair during mitral valve surgery on the early and mid-term prognosis of the tricuspid valve and right heart function in the patients with moderate or less tricuspid regurgitation. MethodsA retrospective study of 461 patients with mitral valve disease requiring cardiac surgery combined with moderate or less tricuspid regurgitation in our hospital from 2011 to 2014 was done. They were 309 males and 152 females with a median age of 53.00 (44.00, 60.00) years. According to whether they received tricuspid valve repair (Kay’s annuloplasty, DeVega’s annuloplasty or annular ring implantation), the patients were divided into a mitral valve surgery only group (a nTAP group, n=289) and a concomitant tricuspid valve repair group (a TAP group, n=172). At the same time, 43 patients whose tricuspid valve annulus diameter was less than 40 mm in the TAP group were analyzed in subgroups. ResultsThe median follow-up duration was 3.00 years (range from 0.10 to 9.30 years). There was no perioperative death. Three months after surgery, the anteroposterior diameter of the right ventricle in the TAP group was significantly improved compared with that in the nTAP group [–1.00 (–3.00, 1.00) mm vs. 0.00 (–0.20, 2.00) mm, P=0.048]. Three years after surgery, the improvement of right ventricular anteroposterior diameter in the TAP group was still significant compared with the nTAP group [–1.00 (–2.75, 2.00) mm vs. 2.00 (–0.75, 4.00) mm, P=0.014], and the patients in the TAP group were less likely to develop moderate or more tricuspid regurgitation (3.64% vs. 35.64%, P<0.001). Annuloplasty ring implantation was more effective in preventing regurgitation progression (P=0.044). For patients with a tricuspid annulus diameter less than 40 mm, concomitant tricuspid valve repair was still effective in improving the anteroposterior diameter of the right ventricle in the early follow-up (P=0.036). Conclusion Concomitant tricuspid valve repair for patients with moderate or less tricuspid regurgitation during mitral valve surgery can effectively improve the tricuspid valve and right heart function in the early and mid-term after surgery. Annuloplasty ring implantation is more effective in preventing regurgitation progression. Patients whose tricuspid annulus diameter is less than 40 mm can also benefit from concomitant tricuspid repair.

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  • Research progress of methylcellulose-based thermosensitive hydrogels applied in biomedical field

    Methylcellulose is a semi-flexible cellulose ether derivative, whose hydrogels are thermosensitive and reversible, with good biocompatibility and adjustable function, and its application has attracted much attention in the biomedical field. In this paper, the application of methylcellulose-based thermo-sensitive hydrogels in biomedical field was reviewed. Based on the mechanism of gelation and influencing factors of methylcellulose, this paper focused on the recent advances in biomedical applications of methylcellulose-based hydrogels, including drug delivery, regenerative medicine, and other related fields. The current achievements in these fields were summarized in the form of lists in this paper to provide ideas and tendencies for future research. Finally, the future development of multifunctional methylcellulose-based hydrogel materials with improved performance was also discussed.

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