west china medical publishers
Author
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Author "王玲" 31 results
  • Effect of background light intensity on the slow components and the oscillatory potentials of the electroretinogram

    Objective To study the response of the retinal neuronal adaptive system to changes of background illumination (BG) by measuring the oscillatory potentials (OPs) and the a- and b-waves of the electroretinogram (ERG) in different BG illuminations. Methods The a- and b-wave and the digitally filtered OPs were simultaneously recorded from Wistar Fu rats aged from 25 to 29 days during dark adaptation (DA) and during 6~8 minutes of BG illuminations at four levels increased successively by steps of two log units, i.e., ldquo;low scotopicrdquo; level of 1.43times;10-6cd/m2, ldquo;high scotopicrdquo; of 1.43times;10-4cd/m2 , ldquo;low mesopicrdquo; of 1.43times;10-2cd/m2 and ldquo;high mesopicrdquo; of 1.43times;10-2cd/m2. Full field stimulus flashes of 75 msec duration and 1.43times;10-2cd/m2intensity was delivered at an interval of 1 minute. Results Five OP wavelets were recorded in DA and during scotopic BG illuminations. The number of wavelets was reduced to three as the eyes were exposed to mesopic BG levels. However, the sum of OPs amplitudes (SOPs) increased as the BG was intensified, except at ldquo;high mesopicrdquo; level, by which a significant decrease of SOPs occurred. The amplitudes of the a-and b-waves remained unchanged at the two scotopic BG and decreased as the BG intensity increased to mesopic levels. Conclusion The response of retinal neural adaptive system of the Albino rat to changes of BG light is more sensitive and robust than the slow components of the ERG. The enhancement of the oscillatory responses at ldquo;low mesopicrdquo; illumination level suggests that using proper BG light may be conducive to reducing the variation of OPs.  (Chin J Ocul Fundus Dis, 2001,17:286-288)

    Release date:2016-09-02 06:03 Export PDF Favorites Scan
  • 经颅磁刺激在帕金森病患者步态异常中的应用

    经颅磁刺激(TMS)是利用变化的高毫安电流产生变化的磁场诱导的感应电场作用于颅内可兴奋组织的过程。TMS以其可进行深部刺激、无痛、非介入等优点,被广泛地应用于帕金森病的研究和治疗中。目前帕金森病患者步态异常发生的病理生理机制尚不清楚,且治疗十分困难。近年来TMS在对帕金森病患者步态异常的研究中得到了较大的进展。现对TMS原理以及在帕金森病患者步态异常研究及治疗中的应用和进展进行综述。

    Release date: Export PDF Favorites Scan
  • Management and prognosis of constrictive pericarditis during pericardiectomy

    Objective To estimate the relationship of methods and drugs for management of constrictive pericarditis during pericardiectomy. Methods We reviewed the records of 45 patients (mean age, 40.24±15.34 years) with a diagnosis of constrictive pericarditis who underwent pericardiectomy in our hospital from 2012 through 2014 year. During operation, inotropic agents, vasodilators and diuretics were used. According to the diuretics, patients were divided into two groups including a furosemide group(group F) with 38 patients and a lyophilized recombinant human brain natriuretic peptide (lrhBNP) group with 7 patients(group B). Results Preoperatively, 30 patients were pulmonary congestion, which was diagnosed by chest radiographs. Pericardiectomy was finished by off pump in 43 patients. Another 2 patients required cardiopulmonary bypass (CPB) for pericardiectomy. In the group F 52.6% of the patients needed vasodilators to reduce cardiac preloading following pericardiectomy. None of other vasodilators were used in the group B. After pericardiectomy, the fluctuation of systolic and diastolic pressure decreased significantly in the group B (P=0.01, respectively). In the group F, the fluctuation of diastolic pressure decreased significantly (P<0.05). Low cardiac output was the most common postoperative problem. One patient accepted postoperative extracorporeal membrane oxygenation (ECMO) support. Postoperative poor renal function was found in 42.2% of the patients. Three of them needed hemofiltration. Postoperative poor renal function accompanied by poor hepatic function was found in 15.6% of the patients. One of them used dialysis and artificial liver. Three patients were respiratory failure with longer mechanical ventilation and tracheotomy. The overall perioperative mortality rate was 6.7% (3 patients). All patients, who died or used with hemofiltration, artificial liver and ECMO were found in the group F. Conclusion More stable haemodynamics after pericardiectomy may occur with using lrhBNP. lrhBNP may reduce postoperative major morbidity and mortality. Because of the small group using lrhBNP in our study, more patients using lrhBNP for pericardiectomy need to be studied.

    Release date: Export PDF Favorites Scan
  • 特发性震颤的遗传学研究进展

    特发性震颤(essential tremor,ET)是最常见的成年起病的神经系统变性疾病之一。ET 分为家族性和散发性 2 种,约一半以上患者存在家族史,遗传因素可能发挥着重要作用。目前,大量研究致力于寻找 ET 发病的风险位点及致病基因。进行 ET 遗传学分析有助于进一步研究其病理生理机制,因此文章从该病的单基因遗传模式及复杂疾病遗传模式 2 个方面对 ET 的遗传学进展进行了阐述。

    Release date:2017-05-18 01:09 Export PDF Favorites Scan
  • Information System for Causauty Management in Major Natural Disaster

    目的:信息系统的改进应用是为确保急诊科预检分诊处将来能使医院对自然灾害事件的伤员救治时以最便捷、最快速的方式录入自然灾害事件伤员的信息资料和快速评估伤情,优先准确的将伤员按病情和就诊区域分类,以便畅通及时救治伤员;在治疗中和日后便于识别、查找、统计灾害事件伤员。方法:LIS(检验系统)+ RIS(影像系统)+ HIS(无纸化办公系统)三合一系统和增加自然灾害伤员的“录入信息资料”眉栏。结果:进一步改进信息网络应用系统后,能满足一般患者信息资料录入和自然灾害事件应急状况下的患者资料录入,实现电子病历和电子处方等信息网络系统,达到院内、科内资源共享。

    Release date:2016-08-26 03:57 Export PDF Favorites Scan
  • Study on macular retinoschisis by optic coherence tomography in eyes with high myopia

    Objective To observe the the clinical characteristics of images of optic coherence tomography (OCT) in highly myopic eyes with retinoschisis. Methods The clincial data of 158 patients (158 eyes) with high myopia diagnosed by examinations of best corrected visual acuity and refraction, indirect stereoscopic ophthalmoloscopy, A/Bscan ultrasonography, and OCT, were retrospectively analyzed. The patients were divided into retinoschisis group and nonretinoschisis group according to the results of OCT (whether the patients had macular reinoschisis at the posterior pole). There were 53 patients (55 eyes, 34.8%) in the former group, and 101 patients (103 eyes, 65.2%) in the latter group. The age, sex, diopter, visual acuity, ocular axial length, and incidence of posterior scleral staphyloma, vitreous traction, and retinal detachment of the two groups were compared. Results B-scan ultrasonography showed posterior scleral staphloma in all of the 158 eyes. OCT indicated that in the 55 eyes in the retinnoschisis group, 15 (27.3%) had inner, 53 (96.4%)had outer, and 7 (12.7%)had middle retinoschisis. The inner and outer one could exist independently or in the same eye, while the middle one was always accompanied by the outer retinoschisis. Two or more types of schisis coexisted in 13 eyes (23.6%), single outer retinoschisis was found in 40 eyes (72.7%), and single inner retinoschisis was found in 2 eyes (3.6%). There were 26 eyes(47.3%)were accompanied with retinal detachment, 13 eyes(23.6%) with macular hole, and 12 eyes (21.8%)with vitreous traction. In the 103 eyes in the nonretinoschisis group, 23 eyes (22.3%)had vitreous traction, 19 eyes (18.4%) had macular hole, and 21 eyes (20.4%)had retinal detachment. The differences of age, diopter and ocular axial length, sex, incidence of macular hole and vitreous traction between the two groups were not statistically significant (Pgt;005). The visual acuity in retinoschisis group was much lower than that in the nonretinoschisis group (Plt;005), and the difference of incidence of the retinal detachment between the two groups was significant (Plt;001). 〖WTHZ〗Conclusion 〖WTBZ〗Macular retinoschisis in eyes with high myopia can exist in inner or middle retina, but most of them locate at outer retina.The patients always have poor visual acuity and are often accompanied by other macular lesions such as retinal detachment.

    Release date:2016-09-02 05:43 Export PDF Favorites Scan
  • 血红素氧合酶对鼠视网膜缺血再灌注损伤的保护作用

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • Apoptosis of vascular endothelial cells induced by transpupillary thermotherapy

    Objective To observe the vascular endthelial cellular apoptosis induced by transpupillary thermotherapy (TTT). Methods Vascular endothelial cells (VEC) cultured in vitro were treated with TTT, hyperthermia and TTT combined with indocyanine green (ICG) pretreatment. The cellular apoptosis was detected by doublelabelled flow cytometer (annexin Vfluroescein isothiocyanate and propidium iodide) analysis, fluorescent microscopy, nucleolus stainned with DNA dye hoechst 33258, DNA ladder detection and electron microscopy. Results Without significant rising of the temperature, TTT couldnprime;t increase the apoptosis of VEC. Pure hyperthermia and TTT combined with ICG pretreatment could increase apoptosis of VEC significantly, and the effect of the latter method was more obvious. The higher power of TTT was used and the longer duration the cells were cultured, the higher apoptosis rate of VEC was. Conclusion The induction of apoptosis of VEC might play an important role in the mechanism of the occlusion of CNV by TTT, and combining with ICG may obviously enhance the apoptosis rate at the same temperature, which may supply a theoretical basis for promoting the clinical effect of TTT.

    Release date:2016-09-02 05:48 Export PDF Favorites Scan
  • 近视眼与视网膜周边部退行性病变

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
  • Diagnostic value of ultrasound for fracture of the distal radius and ulna: a systematic review

    Objective To systematically review the value of ultrasound in the diagnosis of fracture of the distal radius and ulna for providing evidence for clinical diagnosis. MethodsWe searched PubMed, EMbase, The Cochrane Library (Issue 7, 2016), CNKI, CBM and WanFang Data databases for studies about ultrasound in the diagnosis of fracture of the distal radius and ulna from inception to August 1st, 2016. Two reviewers independently screened literatures according to inclusion and exclusion criteria, extracted data, and assessed the risk of bias of included studies by using the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool, and then meta-analysis was performed by using Meta-Disc 1.4 software. ResultsA total of 16 articles involving 1 182 patients and 631 fractures were included. The results of heterogeneity test revealed that there was statistical heterogeneity among the results of studies, thus, random effects model was used for meta-analysis. The results of meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnosis odds ratio for ultrasound diagnosis fracture of the distal radius and ulna were 0.95 (95%CI 0.94 to 0.97), 0.92 (95%CI 0.89 to 0.94), 9.98 (95%CI 5.20 to 19.15), 0.07 (95%CI 0.04 to 0.13), 187.94 (95%CI 65.67 to 537.84), respectively. The area under the SROC curve was 0.976 4. ConclusionUltrasound is a useful non-invasive method as a routine examination for fracture of the distal radius and ulna. Due to the limited quality and quantity of included studies, the above conclusion is needed to be validated by more high-quality studies.

    Release date:2017-02-20 03:49 Export PDF Favorites Scan
4 pages Previous 1 2 3 4 Next

Format

Content