Polypoidal choroidal vasculopathy (PCV) is a fundus disease characterized by choroidal anomalous branch vascular network and terminal polypoidal dilatation. According to its fundus feature, lesion location, imaging feature and disease progression, PCV can be divided into different types or stages. It can be divided into hemorrhage and exudation PCV according to the fundus features, into macular, peripapillary, periphery and mixed types according to the lesion locations. It can also be divided into type 1 and 2 according to the ICGA (indocyanine green angiography) manifestations, and can be classified as early stage and late stage according to disease progression. There were different correlations between different types of PCV and some risk genetic loci, such as ARMS2 (age-related macular degeneration factor 2)/ HTRA1 (high temperature essential protein A1) , C2, complement factor B, complement factor H, and elastin genes. The response to therapy and prognosis are also different between different types. It is important to further study the clinical classification of PCV, to explore the genetic characteristics, influencing factors and treatment or prognosis features of different types of PCV. The results will improve the differential diagnosis of PCV, and the effectiveness of individualized treatment.
Objectives To analyze the risk factors of uterine rupture in pregnancy in Chengdu Women’s and Children’s Central Hospital in recent years. Methods The clinical data of pregnant uterine rupture patients who were hospitalized in Chengdu Women’s and Children’s Central Hospital from January 2011 to December 2017 were collected. The risk factors of uterine rupture in pregnancy were analyzed compared with the maternal delivery during the same period. The SPSS 23.0 software was used for statistical analysis. Results A total of 69 patients with uterine rupture were included, involving 14 cases of complete uterine rupture and 55 cases of incomplete uterine rupture. Compared with the pregnant females who were hospitalized during the same period, the incidence of uterine rupture in patients with scar uterus after cesarean section, history of laparoscopic hysterosalping surgery, placental implantation, twins and uterine malformation was higher, and the difference was statistically significant (P<0.05). Among them, the risk of uterine rupture was greater in the interpregnancy interval (IPI)>24 months after cesarean section in patients with scar uterus. There was no significant difference in the incidence of uterine rupture between the elderly and the multiple pregnant females and the maternal delivery during the same period (P>0.05). Conclusions Scar uterus (postoperative cesarean section), history of laparoscopic hysterosalping surgery, placental implantation, twins, and uterine malformation are possible risk factors for uterine rupture in pregnancy. Among them, patients with scar uterus have a greater risk of uterine rupture with IPI>24 months.
Objective To analyze and compare the domestic quality standard and foreign quality standard of sodium hyaluronate (HA), and to expatiate on the critical process monitoring parameters. Methods Different quality standards of HA were compared by translating and sorting, and some experimental data were analyzed as well as the manufacturing practice was elaborated. Results Differences exist in raw materials standard or specifications of products between domestic and foreign, but the basic control points are concordant. Conclusion The company should set up reasonable and controllable quality standard based on quality requirements and related process characteristics so as to assure the safety and effectiveness of the clinical application.
Objective To review the eradication rate for Helicobacter Pylori (H. pylori) eradication therapy with Ranitidine bismuth citrate (RBC). Methods A systematic review of all the relevant randomized controlled trials (RCTs) was performed according to International Cochrane Collaboration. Data Source RCTs were identified from specialized trials register of Cochrane U GDP Group, the Cochrane library, additional electronic search (including MEDLINE and CBM), handsearching, and personal contact with pharmaceutical companies. Data Selection Randomized clinical trials comparing RBC or RBC in combination with other antibiotics such as proton pump inhibitor, H2-receptor antagonist, other bismuth or placebo were included. No language and blinding limitations were applied. Inclusion criteria Data were extracted independently by two reviewers. The methodological quality of trials was assessed by the Jadad-scale plus allocation concealment. Statistics analysis was managed by using RevMan 4. 1. Results Fifteen randomized clinical trials including 3 638 patients were included, with eight trials of high methodological quality. Meta-analysis indicated that odds ratio was 3.06 (95%CI 2.62 to 3. 58, P lt; 0. 000 01) comparing RBC to controls. But the heterogeneity was significant (P lt; 0. 000 01), so we choose random effects model. Then the odds ratio was 2.05 (95%CI 1. 29 to 3. 25, P=0.002). No serious adverse effects were found. Sensitivity analysis showed that the specimens and the quality of RCT haven’t affected researching result. Conclusion RBC is more effective in Helicobacter Pylori eradication therapy than others.
【摘要】 目的 探讨超声在诊断颈部转移性与淋巴瘤性淋巴结中的应用价值。 方法 2007年1月-2008年12月对经病理证实的102例患者120个颈部淋巴结，应用二维超声、能量多普勒显像（PDI）分为两组:转移性淋巴结68个，淋巴瘤性淋巴结52个。对淋巴结长短比（L/S）、结构及血流分布状态进行分析。 结果 两组淋巴结门消失、局部液化灶、中央血流率比较差异有统计学意义（Plt;0.05），两组出现淋巴结形态不规则、皮质回声减低、淋巴门型血流、周围型血流率比较差异有统计学意义（Plt;0.05）。两组的L/S≤2淋巴结无统计学差异（Pgt;0.05）。 结论 超声检查对颈部转移性淋巴结与淋巴瘤性淋巴结的鉴别诊断有较高价值。【Abstract】 Objective To explore the application value of the ultrasound in diagnosis of metastatic and lymphoma lymph nodes of the neck. Methods From January 2007 to December 2008, 120 neck lymph nodes of 102 patients confirmed by pathology were divided into two groups, including 68 metastatic lymph nodes and 52 lymphoma lymph nodes. The reports of two groups were performed using two-dimensional ultrasonography and power Doppler imaging (PDI). The long-short axis ratio (L/S), structure, blood flow pattern of lymph nodes were studied. Results The rate of the lymph door disappearance, inner liquefacient position and central blood stream in two groups had statistical difference (Plt;0.05). The rate of irregular form, diminution of cortical resonance, blood stream of lymph door and peripheral flow in two groups had statistical difference (Plt;0.05), but the difference of their L/S≤2 had no statistical significance (Pgt;0.05). Conclusion The ultrasonography is a valuable method for diagnosing between neck metastatic nodes and lymphoma lymph nodes.
Objective To investigate the association between polymorphism of S2 locus allele in ADAM33 gene and bronchial asthma in Xinjiang Uygur population.Methods PCR-RFLP was used to determine polymorphismof S2 locus allele in ADAM33 gene in 131 Uygur patients with bronchial asthma ( asthma group) and 90 Uygur healthy individuals ( control group) .Results The comparison of three genotypes and allele frequency of the S2 in the ADAM33 gene had statistical significance in the asthma group and the control group ( X2 =6. 065, P lt;0. 05;X2=5. 255, P lt;0. 025) . The G allele of S2 site increased the risk of asthma( OR =1. 616, P lt;0. 05) . The CG genotype also increased the risk of asthma ( OR= 1. 351,P lt;0. 05) . The FEV1% pred and FVC% pred had significant difference between three genotypes of the S2 site in the ADAM33 gene in the asthma group ( F = 6. 248, P lt; 0. 01; F = 7. 067, P lt; 0. 01) .Conclusion The polymorphism of the S2 site in the ADAM33 gene has significant correlation with asthma in Xinjiang Uygur population, and can increase risk of asthma in the Uygur population.
ObjectiveTo summarize the relationship between microRNAs (miRNAs) and the digestive tract cancer, and to investigate the applicative value of miRNAs in the diagnosis, treatment, and prognosis evaluation of the digestive tract cancer. MethodsDomestic and international papers focusing on the relationship between miRNAs and the digestive tract cancer were retrieved and reviewed. ResultsmiRNAs participated in cell proliferation, differentiation, and apoptosis through gene regulation. The patients with digestive tract cancer were often accompanied with some abnormal expression of miRNAs in circulation, that was closely related to the occurrence and development of tumor. These miRNAs in blood contributed to not only the diagnosis of tumor, but also identification of the primary tumor site, even the clinical and pathological staging. Thus, we could predict the progress, recurrence, and the metastasis of tumor, or perform the evaluation of therapeutic effects. ConclusionCirculating miRNAs can be used as molecular microsensors for the noninvasive early diagnosis, treatment, and prognosis of the digestive tract cancer.