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find Author "王罗俊" 2 results
  • 钙离子通道基因突变与癫痫

    引起癫痫发作的神经元阵发性同步异常放电与离子通道密切相关。因此,编码钙离子通道的基因成为癫痫病因的候选基因之一。现有的抗癫痫药物(AEDs)被证明其作用机制包括抑制钙通道活性。但目前还缺乏高选择性的钙离子通道阻断剂。了解不同发作类型的癫痫患者不同类型的钙离子通道编码基因突变,对理解癫痫的发病机制和今后的精准诊疗很有必要。现对钙离子通道及其分型、编码基因和已发现在癫痫患者中的突变作一综述。

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  • Clinical analysis of 20 patients with electrical status epilepticus during sleep

    ObjectiveTo improve the clinicians’ understanding and treatment level of electrical status epilepticus during sleep by analyzing the clinical data of patients with ESES retrospectively.MethodsWe collected 20 cases from 2018 to 2019 diagnosed in our hospital by clinical and 24-hour video EEG confirmed and analyzed the clinical manifestations, EEG features, seizure type, classification of epilepsy syndrome as well as the imaging findings.ResultsAmong the 20 patients, there were 12 males and 8 females, the mean age was (10.96±2.68) years old, and the first onset age was (8.90±1.93) years old. Epilepsy seizure as the first symptom is most common, the EEG showed a broad or localized sustained discharge, generalized tonic clonic seizure is the main form of seizure type in most patients, ECSWS is the most prominent in the epilepsy syndrome, for small lesion through MR can be found early.ConclusionMost patients have partial or generalized seizures, which have a range of cognitive impairment, mental decline or other issues. It is important to improve the cognitive function, behavior, neuropsychology of patients by long term video EEG monitoring in the early stage.

    Release date:2021-10-25 01:58 Export PDF Favorites Scan
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