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find Author "王胜军" 5 results
  • 腹腔镜下乳头式输尿管膀胱再植术的临床应用

    【摘要】 目的 探讨腹腔镜下乳头式输尿管膀胱再植术的方法和疗效。 方法 应用腹腔镜下乳头式输尿管膀胱再植术治疗8例单纯输尿管末端狭窄、4例输尿管末端狭窄合并结石、2例妇科腹腔镜下输尿管末端损伤患者。 结果 14例均获得成功。手术时间40~180 min,平均80 min;术中出血40~120 mL,住院3~7 d。随访3~12个月,B型超声和静脉肾盂造影显示,肾输尿管积水消失或好转,膀胱造影检查未见输尿管返流。 结论 腹腔镜下乳头式输尿管膀胱再植术不仅操作简便、创伤小,且患者恢复快、抗返流效果好。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 立体定向脑电图引导下射频热凝术治疗局灶性癫痫研究进展

    射频热凝术是一种微创局部热疗技术。早在19世纪60年代, 射频热凝就用于行为性疾病的治疗; 后应用于药物难治性颞叶癫痫, 但效果并不如传统的手术治疗。近几年随着立体定向脑电图的应用, 射频热凝得到改进, 可热凝毁损致痫灶以达到治疗目的。现将归纳立体定向脑电图引导的射频热凝的适应证、方法、研究结果及优点等。

    Release date:2016-10-02 06:51 Export PDF Favorites Scan
  • 电刺激癫痫动物模型的研究进展

    癫痫以脑神经元异常放电引起反复痫性发作为特征。建立癫痫动物模型对研究癫痫的发病机制及治疗具有重要意义。近年来建立了多种动物模型, 主要包括化学点燃和电点燃模型等。经典的癫痫电点燃是对大脑边缘结构进行重复的电刺激, 导致逐渐增强的后放电和行为学上的癫痫发作。电点燃形成后, 即使不再给予刺激, 异常的痫性放电可以持续很长时间, 甚至终生。电刺激癫痫动物模型具有诱导致痫的优点, 而且与人类癫痫发生和形成极为相似。现就电点燃模型、电刺激的部位、参数, 动物点燃的行为表现、点燃方法及病理机制进行综述

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  • Neuroprotective effects and mechanisms of selective histone deacetylases inhibitor MS-275 on lithium-pilocarpine induced seizures in rats

    ObjectiveTo investigate the neuroprotective effects and mechanisms of selective histone deacetylases inhibitor MS-275 on rats after seizures. MethodsA total of 75 rats were randomly divided into 5 groups for treatment:control group,pilocarpine group, treatment group Ⅰ(administered with MS-275, 20mg/kg, once a day,intraperitoneally in 7 consecutive days), treatment group Ⅱ(administered with MS-275, 40mg/kg, once a day, intraperitoneally in 7 consecutive days), MS-275 pretreatment group. We used lithium and pilocarpin to induce seizures. Behaviors of rats in each group were observed. At 72 hours after seizures, Nissl staining and immunohistochemical were respectively used to evaluate the loss of neurons and histone acetylation levels of hippocampal CA1 and CA3 regions in each group. Escape latency in the control group, treatment group Ⅰ, treatment group Ⅱ and MS-275 pretreatment group were longer than pilocarpine group(P<0.05). ResultsCompared with the pilocarpine group, rats in MS-275 pretreatment group could delay pilocarpine-induced seizures and reduce mortality (P<0.05). Degree of neuronal loss and degeneration in both treatment group Ⅰ and treatment group Ⅱ were reduced compared with the pilocarpine group (P<0.05) and the level of histone acetylation in hippocampal CA1 and CA3 regions of the rats were increased compared with the pilocarpine group (P<0.05). ConclusionHDACs inhibitors MS-275 can improve the neuronal damage, histone deacetylation of rats' brain and rats cognitive decline, which can exert an neuroprotective effect on rats after seizures, whose mechanism may be related to its antiinflammatory effect.

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  • Clinical and electroencephalogram features of dyssynergia cerebellaris myoclonica

    ObjectiveWe report two family and one sporadic case with dyssynergia cerebellaris myoclonica, investigate the clinical and neural electrophysiological features. MethodsThe proband and sporadic patient was examined by clinical, neuroimaging, video-EEG and synchronous electromyography. ResultsThere were 6 patients with dyssynergia cerebellaris myoclonica of the 27 family members in the first family(3 male and 3 female). There were 4 patients with dyssynergia cerebellaris myoclonica of the 20 family members in the second family(2 male and 2 female). All patiens had disproportionately myoclonus, epilepsy and progressive cerebellar ataxia. EEG showed bursts of spike-slow wave, polyspilke-slow wave distributing in the bilateral brain both in ictal and interictal period, sometimes it is especially in central, parietal and frontal area. EEG showed bursts of spike-slow wave, polyspilke-slow wave distributing in the central, parietal and frontal area in interictal period. Pathology of the skin and muscles are normal. ConclusionThe diagnosis of dyssynergia cerebellaris myoclonica was mainly based on typical clinical manifestations, brain MRI and EEG changes.Long time video EEG and synchronous EMG is important for the diagnosis. Skin and muscles pathology can be normal.

    Release date:2016-10-02 06:51 Export PDF Favorites Scan
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