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find Author "王菊莉" 6 results
  • Research progress of executive function in temporal lobe epilepsy

    Temporal lobe epilepsy is the most common type of epilepsy in clinic. In recent years, many studies have found that patients with temporal lobe epilepsy have different degrees of influence in executive function related fields. This influence may not only exist in a certain field of executive function, but may be affected in several fields, and may be related to the origin site of seizures. However, up to now, there is no unified standard for the composition of executive function, and it is widely accepted that the three core components of executive function are working memory, inhibitory control and cognitive flexibility/switching. In addition, the International League Against Epilepsy proposed a new definition in 2010, and epilepsy is a brain network disease. There is a close relationship between brain neural network and cognitive impairment. According to the cognitive field, the brain neural network can be divided into six types: default mode network, salience network, executive control network, dorsal attention network, somatic motor network and visual network. In recent years, there has been increasing evidence that four related internal brain networks are series in a range of cognitive processes. The executive dysfunction of temporal lobe epilepsy may be related to the changes of functional connectivity of neural network, and may be related to the left uncinate fasciculus. This article reviews the research progress related to executive function in temporal lobe epilepsy from working memory, inhibitory control and cognitive flexibility, and discusses the correlation between the changes of temporal lobe epilepsy neural network and executive function research.

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  • 癫痫的饮食干预研究进展

    癫痫是一种以具有持久性的致痫倾向为特征的脑部疾病,对于不适合手术的难治性癫痫患者,饮食疗法是一个很好的辅助疗法。饮食疗法包括经典生酮饮食(Ketogenic-diet,KD)、改良阿特金斯氏饮食(Modifified atkins diet,MAD)、低血糖指数饮食(Low glycemic index treatment,LGIT)、中链甘油三酯饮食(Medium-chain triglyceride diet,MCTD)以及益生菌饮食。文章就不同饮食方案对癫痫的疗效证据、不良反应和潜在的病理生理机制作一综述,以期为 KD 治疗癫痫的临床应用提供一定参考。

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  • ARID1B基因导致Coffin-Siris综合征伴癫痫一例并文献复习

    Release date:2022-02-24 02:04 Export PDF Favorites Scan
  • SLC13A5 基因突变致早发幼儿癫痫性脑病 25 型一例并文献复习

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  • Clinical study of pirenpanet as add-on therapy for intractable epilepsy

    Objective To observe the efficacy and adverse reactions of pirenpanet in patients with refractory epilepsy treated with add-on therapy. MethodsForty-one patients with medically refractory epilepsy were selected from January 2021 to December 2021 in the Department of Epilepsy of Jiamusi Central Hospital, among which 25 males and 16 females. The self-control study was conducted before and after the treatment with pirenpanet. The observation period was 1 year, and the clinical efficacy, platelet, liver and kidney function and EEG discharge index were observed at 6 months and 12 months respectively. Changes in seizure frequency after treatment were divided into the following 3 groups: effective control: no seizure; effective: seizures reduced by 50% ~ 99%; Ineffective: < 50% reduction in seizures or exacerbation. Results Among the 41 patients with drug-refractory epilepsy, 8 (8/41, 19.51% P < 0.05) were seizure-free, 17 (17/41, 41.46% P < 0.05) were effective, and the total effective rate was (25/41, 60.98%); Sixteen cases (16/41, 39.02%) were ineffective. There were 31 children in 41 cases (31/41, 75.61%), of which 18 cases (18/31, 58.06%) were effective, 16 cases (16/31, 51.61%) had mental and motor retardation, and 8 cases (8/16, 50%) were effective; There were 10 adults (10/41, 24.39%) and 7 effective patients (7/10, 70%). After one year's treatment, the EEG changes of the patients were observed, and the abnormal discharge of 6 patients was reduced according to the discharge index, 2 patients had no abnormal discharge, and the other patients had no obvious EEG changes. Conclusion Pirenpanet is effective and safe as an add-on therapy for medically refractory epilepsy.

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  • PCDH19簇集性癫痫一例

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