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find Author "王贵和" 6 results
  • MTS1/p16基因在原发性胆囊癌中的表达及临床意义

    Release date:2016-09-08 02:00 Export PDF Favorites Scan
  • Relationship Between Topical Reactive Lymphoid Hyperplasia and Postoperative Recurrence and Survival Time of Gastric Cancer Patients

    ObjectiveTo investigate the relationship between topical reactive lymphoid hyperplasia and postoperative recurrence and survival of gastric cancer patients. MethodsThe clinical and pathological data of gastric cancer patients who underwent D2 radical gastrectomy from January 2007 to July 2009 were retrospectively analyzed. Based on the number of reactive lymph nodes, cases were divided in to topical reactive lymphoid hyperplasia group (RLH, n=18) and non-RLH group (n=43) by using a median method. The postoperative disease-free survival (DFS) and overall survival (OS) rates of patients in different groups were compared using Kaplan-Meier method and log-rank test, respectively. ResultsThere were no significant difference between the two groups in age, gender, pathological stage, surgical approach, extent of surgery or methods of postoperative chemotherapy (P > 0.05). The median disease-free survival time was 50 months in RLH group, and the median disease-free survival time was 39 months in non-RLH group. DFS of patients in RLH group was significant higher than non-RLH group (66.7% vs. 34.9%, P=0.048). The median survival time was 53.6 months and 52.3 months, respectively, in RLH group and non-RLH group. No difference was found in OS between the two groups (72.2% vs. 60.5%, P=0.338). ConclusionTopical reactive lymphoid hyperplasia reactive the immunity of gastric cancer patients and contact postoperative DFS rate.

    Release date:2016-10-25 06:10 Export PDF Favorites Scan
  • Effects of Vitamin K2 Plus 5-Fluorouracil on Proliferation,Migration,and Invasiveness of Hepatocellular Carcinoma Cells

    ObjectiveTo investigate effects of vitamin K2 in combination with 5-fluorouracil (5-FU) on proliferation, migration, and invasiveness of hepatocellular carcinoma cells in vitro. MethodsHuman hepatocellular carcinoma PLC/RAF/5 cells were cultured in vitro and exposed to vitamin K2 (10 μmol/L) and 5-FU (10 μg/mL) alone or in combination for 24 h. The cell proliferation, migration, and invasiveness were measured by CCK-8 assay, wound-scratch assay, and Matrigel invasion chamber assay, respectively. ResultsThe abilities of proliferation, migration, and invasion of PLC/RAF/5 cells were significantly decreased after either alone vitamin K2 or 5-FU treatment (all P<0.05) as compared with the control cells, and above effects were further enhanced by the vitamin K2 in combination with 5-FU treatment as compared with either alone drug treatment (all P<0.05). ConclusionCombination use of vitamin K2 and 5-FU might be an effective method for inhibiting growth, migration, and invasiveness of hepatocellular carcinoma cells.

    Release date:2016-11-22 10:23 Export PDF Favorites Scan
  • 局部晚期不可切除胃癌转化治疗方案的初步研究

    目的初步研究替吉奥、甲磺酸阿帕替尼联合经导管动脉灌注化疗栓塞(SATA 方案)对局部晚期不可切除胃癌转化治疗的安全性及疗效。方法对 2018 年 9 月至 2019 年 10 月期间铜陵市人民医院胃肠外科收治的采用 SATA 方案进行转化治疗的 7 例局部晚期不可切除胃癌患者的临床病理资料进行回顾性分析。结果本研究 7 例患者均按计划完成了转化治疗,无严重不良事件发生。7 例患者转化治疗效果评估均为部分缓解,其中 6 例患者接受了手术治疗,结合术中及术后病理检查结果评估其中 5 例患者达到了根治性切除(R0+D2/D2+),有 1 例患者为 R1 切除。结论本研究初步研究结果证实了对局部晚期不可切除胃癌采用 SATA 方案进行转化治疗安全、可靠,转化成功率高,但仍需进一步扩大样本量并开展随机对照研究进行进一步验证。

    Release date:2021-02-08 07:10 Export PDF Favorites Scan
  • 两种机械吻合方式在腹腔镜辅助右半结肠癌术中的回顾性对照研究

    目的比较体外机械性侧侧吻合与端侧吻合在腹腔镜辅助右半结肠癌根治术中的应用效果。方法回顾性分析笔者所在医院 2015 年 6 月至 2018 年 6 月期间采用机械吻合进行消化道重建的 89 例腹腔镜辅助右半结肠癌根治术患者的临床资料,其中机械性侧侧吻合 32 例,机械性端侧吻合 57 例;比较 2 组患者的一般资料、手术时间、术中出血量、术后首次肛门排气时间、耐受流质饮食时间和术后住院时间;并比较术后并发症发生情况。结果2 组患者的一般资料、术中出血量、耐受流质饮食时间和术后住院时间的差异均无统计学意义(P>0.05);端侧吻合组手术时间短于侧侧吻合组 [160.0(150.0,177.5) min 比 170.0(156.3,203.8)min],差异有统计学意义(P=0.049);端侧吻合组首次肛门排气时间短于侧侧吻合组 [(2.5±0.9)d 比(3.0±1.0)d],差异有统计学意义(P=0.021);2 组患者术后各并发症发生率差异无统计学意义(P>0.05)。结论腹腔镜辅助右半结肠癌根治性切除手术中相比机械性侧侧吻合,机械性端侧吻合的手术时间及术后首次肛门通气时间较短,其并发症无统计学差异,提示机械性端侧吻合可能更具优势。

    Release date:2019-06-26 03:20 Export PDF Favorites Scan
  • Effects of parenteral nutrition supplemented with omega-3 fish oil fat emulsion on nutrition, stress, and liver function in patients with gastric cancer after operation

    ObjectiveTo evaluate the value of omega-3 fish oil fat emulsion in parenteral nutrition support after radical resection of gastric cancer patients.MethodsThe clinical data of 80 patients in Tongling Peopl’s Hospital undergoing radical resection of gastric cancer from March 2018 to September 2019 were enrolled by retrospective method. Of them, 40 patients were treated with routine parenteral nutrition (control group) and 40 patients were treated with extra 100 mL omega-3 fish oil fat emulsion after operation (observation group). Nutritional and stress indicators included blood total albumin (TP), albumin (ALB), c-reactive protein (CRP), and procalcitonin (PCT) on one day before operation, and 1st, 3rd, and 7th day after operation were collected. The collected indexes of liver function included blood cholesterol (CHO), triglyceride (TG), total bilirubin (TBIL), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma glutamyl transpeptidase (γ-GT) on one day before operation, and 3rd and 7th days after operation.Results① Nutritional indicator. There was no significant differences in TP and ALB levels between the two groups on one day before operation, and on the 1st, 3rd, and 7th day after operation (P>0.05). In the same group compared with one day before operation, the average TP level of the control group and the observation group decreased on the 1st, 3rd, and 7th day after operation (P<0.05), and in the control group and the observation group, the ALB level decreased on the 1st day after operation (P<0.05), and increased on the 7th day after operation (P<0.05). ② Stress index. There was no significant difference in CRP and PCT levels between the two groups on one day before and one day after operation (P>0.05), and the CRP and PCT levels in the observation group were lower than those in the control group on the 3rd day and 7th day after operation (P<0.05). Compared with the CRP and PCT levels on the one day before operation, the average CRP and PCT levels in the observation group and the control group increased on the 1st, 3rd, and 7th day after operation (P<0.05). ③ Liver function index. There was no significant differences in CHO, TG, and γ-GT levels between the two groups on one day before operation and the 3rd day after operation (P>0.05), but the above indexes of observation group were lower on the 7th day after operation than those of the control group (P<0.05). There was no significant differences on TBIL, ALT, and ALP levels between the postoperative observation group and the control group (P>0.05). Compared with one day before operation in the same group, there was no significant difference on CHO and ALP levels on 3rd and 7th day after operation in both the observation group and control group (P>0.05). There was no significant differences in TG and TBIL levels in the observation group on 3rd and 7th day after operation (P>0.05), but the TG and TBIL levels in the control group were increased on 7th after operation (P<0.05), and the ALT and γ-GT levels in the observation group and the control group on 7th day after operation were increased in the same group compared with one day before operation (P<0.05).ConclusionParenteral nutrition with omega-3 fish oil fat emulsion do not improve the recent postoperative nutritional status, but reduce the inflammatory stress response and protecte liver function in patients with gastric cancer after operation.

    Release date:2020-08-19 12:21 Export PDF Favorites Scan
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