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find Author "王雨婷" 2 results
  • Efficacy and safety of ciprofloxacin for non-cystic fibrosis bronchiectasis: a meta-analysis

    ObjectivesTo systematically review the efficacy and safety of ciprofloxacin for non-cystic fibrosis bronchiectasis.MethodsDatabases including PubMed, EMbase, The Cochrane Library, CBM, VIP, CNKI and WanFang Data were electronically searched from inception to August 2018 to collect randomized controlled trials (RCTs) on ciprofloxacin in the treatment of non-cystic fibrosis bronchiectasis. Two reviewers independently screened literature, extracted data, and assessed risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 9 RCTs involving 1 666 patients were included. The results of meta-analysis showed that: compared with control group, the ciprofloxacin more efficiently eradicate bacteria from sputum (RR=4.34, 95%CI 2.04 to 9.23, P=0.000 1), decrease risk of the exacerbations (RR=0.81, 95%CI 0.71 to 0.93, P=0.002) and the mean bacterial load (MD=–4.08, 95%CI –6.29 to –1.87, P=0.001). However, there were no significant differences between two groups in clinical efficiency and adverse events.ConclusionsThe current evidence shows that, ciprofloxacin can decrease the mean bacterial load and risk of the exacerbation, and more efficiently eradicate bacteria from sputum in non-cystic fibrosis bronchiectasis patients. Due to limited quality and quantity of the included studies, more studies are required to verify the conclusions.

    Release date:2019-06-24 09:18 Export PDF Favorites Scan
  • 支气管镜联合消化内镜成功治疗食管癌术后气管食管瘘和胃底胸膜瘘一例

    目的 探索气管食管瘘及胃底胸膜瘘的临床救治方法。方法 回顾分析我院呼吸与危重症医学科经支气管镜联合消化内镜成功治疗食管癌术后气管食管瘘和胃底胸膜瘘1例。结果 患者男,64岁,因“进食后胸痛3周余”于2021年6月21日入胸外科,23日胃镜示食管中段新生物,病理为中分化鳞癌,25日行胸腔镜下右胸腹两切口食道癌根治术。术后第4天患者出现胸痛伴发热,7月5日胸部CT示左侧液气胸,胸腔镜探查术置管引流后脱机困难,10日转入呼吸与危重症医学科,数字减影血管造影下介入和气管镜检查明确诊断气管食管瘘和胃底胸膜瘘,保守治疗1个月效果不佳,经多学科讨论后先行气管镜引导下气道Y型覆膜支架植入封堵术,后行胃镜下氩离子束凝固术烧灼+气管食管瘘和胃底胸膜瘘钛夹夹闭术。患者术后痰量减少,无发热,复查CT两肺感染和胸腔积液明显吸收,消化道造影未见钡餐外溢现象,患者顺利脱机堵管,拔除气切套管后康复出院,门诊随访病情稳定。结论 食管癌术后短期内同时出现气管食管瘘和胃底胸膜瘘,实属罕见,救治难度较大。该患者的成功救治说明支气管镜联合消化内镜是治疗气管食管瘘和胃底胸膜瘘的有效方法,值得借鉴和推广。

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