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find Author "王飞" 42 results
  • 支气管类癌的诊断与治疗

    目的 探讨支气管类癌的临床特点、病理特征、诊疗和预后。 方法 分析首都医科大学附属北京友谊医院1999年1月至2012年1月治疗12例支气管类癌(bronchial carcinoid) 患者的临床资料,其中男7例,女5例;年龄33~69 (49.3±12.4) 岁。主诉为咳嗽、咳痰4例,胸痛3例,痰中带血1例,刺激性干咳1例,另外3例系体检发现;病灶位于右肺7例,左肺5例;中心型病变7例,周围型病变5例。12例中肺叶切除术10例,全肺切除术2例。 结果 全组患者无严重手术并发症,无围手术期死亡。术后免疫组织化学确诊典型类癌8例,不典型类癌4例;12例中8例获得有效随访,随访时间1~76个月,其中典型类癌患者5例,均生存;不典型类癌3例,2例生存,1例死于远处转移。 结论 支气管类癌行支气管镜检查半数可见肿物多隆起于支气管表面,边界清楚、表面光滑,行正电子发射断层扫描(PET)可见病灶处放射性浓聚;术后行免疫组织化学检查可确诊;手术切除可获长期生存,预后主要与病理类型、有无远处转移等有关。

    Release date:2016-08-30 05:51 Export PDF Favorites Scan
  • Ⅰ型神经纤维瘤病合并腹腔恶性外周神经鞘瘤一例

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  • 巨淋巴结增生症的临床特点及外科治疗

    目的 探讨巨淋巴结增生症(castleman’s disease,CD)的临床特点及外科治疗方法。 方法 分析2005年10月至2010年3月首都医科大学附属北京友谊医院收治9例巨淋巴结增生症患者的临床资料,其中男7例、女2例,平均年龄51.8岁。出现临床症状2例,包括咳嗽、胸闷、发热、乏力、盗汗等,其他为体检发现。9例患者术前均行胸部X线片、胸部CT、单光子发射计算机断层成像术(SPECT) 和腹部B超检查。接受手术切除治疗。 结果 在临床分型中,单中心型CD 5例,多中心型CD 4例;病理分型中,透明血管型6例,浆细胞型1例,混合型2例。由于瘤体血供丰富,术中出血较多,平均出血量514.4 ml,最多2 500 ml。5例单中心型CD患者均生存,无复发;多中心型CD 4例,随访3~5年,4例均生存,其中2例分别于术后1年、3年后复发,再次行手术切除,术后病理结果与第1次手术相同。 结论 CD的诊断主要依靠影像及病理学,而最后确诊还应以病理学为准。无论哪种类型的CD外科切除均为有效的治疗方法,单中心型CD手术切除病变可达到彻底治愈的目的,而多中心型CD手术切除后仍有复发可能,应适当联合化疗、放疗等其他治疗手段。

    Release date:2016-08-30 05:45 Export PDF Favorites Scan
  • 纵隔巨大脂肪瘤一例

    Release date:2016-08-30 05:57 Export PDF Favorites Scan
  • 乙醛脱氢酶1与肿瘤干细胞相关性研究

    【摘要】 乙醛脱氢酶(acetaldehyde dehydrogenase,ALDH)广泛存在于不同组织中,是一类具有高度氧化活性的胞浆酶类。随着肿瘤干细胞理论的提出,ALHD1被发现为多种肿瘤干细胞的表面标志,在肿瘤的诊断、治疗、判断预后等方面发挥一定作用。现就ALDH1在不同肿瘤的具体作用及在放化疗耐药方面的机制作一综述。

    Release date:2016-09-08 09:24 Export PDF Favorites Scan
  • 循证医学与知识转化

    循证医学研究的结论日益增多,如何对其结论进行综合利用是研究者面临的问题。知识转化是指知识在研究者和用户构成的一个相互作用的复杂系统内,进行交换、合成和合乎伦理的应用,通过改善健康、改进服务、提高产品质量以及加强卫生保健系统来加速各方从研究中获益的过程。循证医学与知识转化关系紧密,现对其进行简要阐述。

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  • 清热化痰法治疗慢性阻塞性肺疾病急性加重期的研究进展

    慢性阻塞性肺疾病(COPD)是临床多发病,急性加重期的有效防控是疾病预后的关键所在。中医对COPD有较好的治疗效果,其中清热化痰法是主要的治疗方法,现就清热化痰法近年在COPD的治疗研究作一综述。

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  • ARTHROSCOPIC TREATMENT OF PIGMENTED VILLONODULAR SYNOVITIS OF ANKLE

    ObjectiveTo investigate the effectiveness of arthroscopic treatment of pigmented villonodular synovitis (PVNS) of the ankle. MethodsTwelve patients who were initially diagnosed as having PVNS of the ankle were treated between January 2005 and May 2012.There were 6 males and 6 females,aged 20-50 years (mean,35.4 years).Disease duration ranged from 6 months to 12 years (median,3.6 years).One case of recurrence was included.The preoperative American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score was 55.5±7.6.According to degree and range of the PVNS lesions,4 cases of local PVNS were treated with arthroscopic debridement,and 8 cases of diffuse PVNS were treated with arthroscopically assisted arthrotomy;and local radiotherapy was given in all patients after operation. ResultsPrimary healing of incision was obtained in all patients.The mean follow-up time was 2.8 years (range,1-6 years).At 12 months after operation,no obvious pain,swelling,and limited range of motion of the ankle were observed.The AOFAS score was increased to 84.3±3.4 at 12 months,and it was significantly higher than that at preoperation (P<0.05) and at 3 months after operation (82.8±3.8)(P<0.05).There was no recurrence during follow-up. ConclusionArthroscopic arthrotomy combined with postoperative radiotherapy are recommended for PVNS of the ankle according to the PVNS lesion degree and range.And arthroscopically assisted surgery has many advantages of less traumas and hemorrhage,fast recovery,and less complications.

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  • Clinical research progress on brain natriuretic peptide and amino-terminal pro-brain natriuretic peptide

    Brain natriuretic peptide (BNP) and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were the main members of the natriuretic peptide family. BNP has the effects of diuretic sodium, reducing sympathetic nervous system activity, dilating blood vessels, and improving the pathological remodeling of heart. Plasma BNP/NT-proBNP levels have been widely used in the diagnosis, severity assessment, prognosis prediction and treatment guidance of heart failure. In recent years, BNP/NT-proBNP has become a research hotspot in the diagnosis and and prognosis judgment of atrial fibrillation, recurrence of atrial fibrillation after radiofrequency ablation and cardioversion and congenital heart disease in infants and children, prediction of postoperative complications, and drug development. This article reviews the latest advances in clinical application and research progress on BNP/NT-proBNP.

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  • APPLICATION OF PHOTOSHOP CS16.0 SOFTWARE IN PREOPERATIVE OSTEOTOMY DESIGN OF ANKYLOSING SPONDYLITIS KYPHOSIS

    ObjectiveTo introduce the application of Photoshop CS16.0 (PS) software in preoperative osteotomy design of ankylosing spondylitis kyphosis (ASK), and to investigate applied values of the preoperative design. MethodsBetween March 2009 and March 2013, 21 cases of ASK were treated through preoperative osteotomy design by using PS software. There were 16 males and 5 females, aged from 23 to 50 years (mean, 34.2 years). The deformity included thoracolumbar kyphosis in 14 cases, thoracic kyphosis in 2 cases, and lumbar kyphosis in 5 cases. The ultimate osteotomy angle of preoperative plans and the location and extent of osteotomy were determined by the osteotomy design, which guided operation procedures of the surgeon. The actual osteotomy angle was obtained by measuring Cobb angle of osteotomy segment before and after operation. The sagittal parameters of spine and pelvis including global kyphosis (GK), lumbar lordosis (LL), sagittal vertical axis (SVA), pelvic incidence (PI), pelvic tilt (PT), and chin brow-vertical angle (CBVA) were measured at preoperation, at 1 week after operation, and last follow-up. The clinical outcomes were assessed by simplified Chinese Scoliosis Research Society-22 (SRS-22) questionnaire and Oswestry disability index (ODI). ResultsNo complications occurred in the other cases except 1 case of dural tear during operation and 1 case of nerve injury after operation, and primary healing of incision was obtained. All patients were followed up 14 to 45 months (mean, 26.3 months). The SRS-22 and ODI scores at 1 week after operation and last follow-up were significantly improved when compared with preoperative scores (P<0.05), but no significant difference was found between at 1 week and last follow-up (P>0.05). The preoperative planned osteotomy angle and the postoperative actual osteotomy angle were (34.2±10.5)° and (33.7±9.7)° respectively, showing no significant difference (t=0.84, P=0.42). The CBVA, GK, SVA, PT, and LL were significantly improved when compared with the preoperative values (P<0.05), but no significant difference was found between at 1 week and last follow-up (P>0.05). At last follow-up, no failures of internal fixation was found, and bony fusion was obtained. ConclusionThe preoperative osteotomy design by using PS software can precisely recover the spinal sagittal balance and horizontal angle of view, so it can effectively avoid excessive correction and insufficient correction of the deformity and obtain good effectiveness in treating ASK.

    Release date:2016-08-25 10:18 Export PDF Favorites Scan
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