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find Author "田飞" 2 results
  • Research of TAP Induction The Pancreatic Acinar Cells to Release HMGB1 in Rat

    Objective To explore the secretion law of high mobility group box 1(HMGB1)in rat pancreatic acinar cells induced by trypsin activation peptide(TAP)and release of HMGB1 affected by ethyl pyruvate(EP). Methods The experiment was performed in 12 SD rats. The pancreatic acinar cells of rats were taken out and then separated into three groups:control group, TAP group, and EP group. TAP was added into TAP group and EP group(keep TAP at a final concentration of 3 nmol/L), respectively, but EP was added into EP group only (keep EP at a final concentration of 28 mmol/L). The expressions of HMGB1 mRNA and protein were detected by using real-time quantitative reverse transcription polymerase chain reaction(RT-PCR)or Western blot at 3 h, 6 h, 12 h, and 24 h time point, respectively. The relationship between HMGB1 and TAP action time was explored by rank correlation. Results Compared with control group, the expressions of HMGB1 mRNA and protein were increased with prolongation of the TAP action in TAP group and EP group(P<0.05). Compared with TAP group, the expressions of HMGB1 mRNA and protein were decreased in EP group(P<0.05). The expressions of HMGB1 mRNA and protein were increased with prolongation of the TAP action(P<0.05), and were highest at 12 h time point(P<0.01)in TAP group. There were positive correlation between the expressions of HMGB1 mRNA and protein and TAP action time(rs=0.971, P<0.01;rs=0.966, P<0.01).Conclusions TAP can induce the release of HMGB1 in pancreatic acinar cells. There is positive relationship between TAP in early stage and HMGB1 in later period of acute pancreatitis. EP can inhibit the release of HMGB1.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • 尼达尼布治疗放射性肺损伤一例并文献复习

    目的探讨放射性肺损伤的发病机制、临床表现、影像学特点、可能的治疗手段及预后。方法分析 1 例确诊为肺鳞癌合并放射性肺损伤并接受尼达尼布治疗患者的临床资料,结合相关文献复习,总结其临床特点、治疗过程及预后。结果本例为 72 岁男性肺鳞癌患者,经同步放化疗和放射性粒子植入术后并发放射性肺损伤,主要症状为活动后气促,胸部 CT 表现为双肺磨玻璃影和网格影,右下肺显著。经尼达尼布规范化治疗 4 个月后,临床症状以及影像学都明显缓解,随访 1 年,病情持续稳定,未见明显不良反应。文献复习发现,放射性肺损伤患者临床上多表现为干咳、发热及呼吸困难,重症患者可危及生命,影像学多表现为放射靶区的片状影,多以肺实变伴支气管充气征为主。最常用的治疗药物为糖皮质激素,也有少部分患者对激素治疗反应不佳,新的治疗手段仍在探索之中。结论放射性肺损伤是恶性肿瘤患者放疗过程中较常见的并发症,但目前治疗手段有限,尼达尼布作为一种新型的小分子靶向药,可能对放射性肺损伤具有一定的修复作用。

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