目的 初步探讨影响男性乳腺癌患者预后的因素。 方法 收集2003年1月－2011年12月经病理确诊、接受治疗、临床资料较完整的36例男性乳腺癌患者的临床资料。采用对数秩检验和Cox回归分析影响男性乳腺癌患者预后的因素。 结果 36例患者无进展生存期（PFS）为3～95个月，中位PFS为45个月。单因素分析显示：肿瘤直径（P=0.001）、阳性淋巴结（P=0.001）、TNM分期（P＜0.001）、手术方式（P=0.001）是影响预后的因素。多因素分析显示：阳性淋巴结（P=0.024）和TNM分期（P=0.022）是影响预后的主要因素。 结论 阳性淋巴结和TNM分期是影响预后的主要因素，以手术为主的综合治疗模式是提高男性乳腺癌患者生存率的重要措施。
目的 对19例男性乳腺癌的发病情况及诊治过程和结果进行回顾性总结。方法 选择我院1973年至1997年收治的19例男性乳腺癌患者，并对其发病特点及诊治情况、预后进行分析。结果 男性乳腺癌发病率低(1.2%)，发病年龄高，平均55岁，病程长，平均3.75年，病理类型均为浸润型。治疗均采用手术切除，加术后放、化疗及内分泌治疗。结论 男性乳腺癌较少见，病程长，恶性程度高，预后差。由于其在临床表现上无特异性，故极易被忽视或误诊。由于上述特点，要提高男性乳腺癌的存活率，早期诊断及治疗就显得尤为重要。
The sonographic features of male breast lesions, which underwent ultrasound examination in our hospital for the past 10 years, were retrospectively analyzed. Sonographic features of these lesions were standardized as BI-RADS image lexicon. The differences in ultrasonic malignant signs were assessed between the benign and the malignant diseases. Between the two groups, incomplete boundary was statistically different. The specificity was above 95% within the two groups in terms of speculated margin, echogenic halo, calcification, axillary lymphadenopathy, thickening of skin and eccentric of mass to the nipple. High-frequency sonographic examination has a high level of differential diagnosis for male breast lesions.
ObjectiveTo summarize the progress of diagnosis and treatment in male breast cancer. MethodsThe literatures about the research progress of diagnosis and treatment in male breast cancer were reviewed. ResultsThe diagnosis of male breast cancer relied mainly on clinical manifestations and imaging manifestations, the main treatment of male breast cancer was modified radical operation, combining with radiotherapy, chemotherapy, endocrine therapy, and targeted therapy. ConclusionsThe treatment of male breast cancer is mainly reference the treatment of female breast cancer, which is lack of a clear standard of treatment. Indepth study on the molecular genetic level will provide more accurate care decisions for the treatment of male breast cancer.
ObjectiveTo summarize the research progress of the cause, treatment, and other aspects in male breast cancer (MBC). MethodsThrough reading the related literatures, relevant literatures of MBC were reviewed. ResultsFamily history, BRCA1/2 mutation, the imbalance of level of estrogen and androgen, and other factors were risk factors of the MBC. Sentinel lymph node biopsy (SLNB) was feasible in the MBC. Radiotherapy could control local recurrence of MBC, and chemotherapy may be beneficial for long-term survival rate of MBC. The endocrine therapy principle for MBC was not exact as female breast cancer (FBC). ConclusionsMBC has many risk factors. Radiotherapy, chemotherapy, and endocrine therapy are benefit to MBC patients, but it still needs to be confirmed by many high-quality clinical researches of large sample.
Objective To investigate the relationship between skin/pectoral muscle invasion and the prognosis of male breast cancer. Methods Clinical data and follow-up information of 79 male breast cancer patients who received treatment between September 2008 to April 2020 in West China Hospital were retrospectively reviewed, to analyze the clinicopathological features of male breast cancer and prognostic value of skin/pectoral muscle invasion. Results Among 79 male breast cancer patients, a total of 23 patients (29.1%) were with skin/pectoral muscle invasion at diagnosis. All the patients were followed up, with a median follow-up period of 63.3 months (1.0–204.5 months). Within follow-up period, 8 patients (10.1%) suffered from relapse, 19 patients (24.7%, 19/77) suffered from metastasis, and 4 patients (5.1%) died. Multivariate Cox proportional risk regression model suggested that patients with skin/pectoral muscle invaded had poor disease free survival [RR=4.48, 95%CI (1.08, 18.52), P=0.038]. Conclusions Skinor pectoral muscle invasion might be a valuable prognostic factor for male breast cancer patients. However, limited by sample size, the conclusion should be proved by further high-level studies.