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find Author "白江博" 3 results
  • EXPERIMENTAL STUDY ON HUMAN AMNIOTIC MEMBRANE FOR REPAIRING TENDON SHEATH DEFECT

    Objective To investigate the feasibility and effect of human amniotic membrane in prevention of tendon adhension after tendon sheat defect repair. Methods The amniotic membrane in size of 1.5 cm × 1.0 cm was harvested from human placenta which was voluntary donated from maternal after cesarean. Forty healthy male Leghorn chicken (aged 3-6 months) were selected, weighing (1.86 ± 0.04) kg. The model of flexor digitorum profundus tendon and tendon sheath defects was established at the third toe. After repair of the flexor digitorum profundus tendon, the human amniotic membrane was used to repair the tendon sheath defect in the right foot (group A), but tendon sheath defect was not repaired in the left foot (group B) . At 1, 2, 4, and 6 weeks after operation, the gross and histological observations were done; the degree of tendon adhesions was graded according to Tang’s tendon adhesion general observation grading standards; and the biomechanical properties (tendon slip length and total flexion angle) were tested. Results All animals survived after operation and incisions healed. Gross and histological observations showed that the new tendon sheath formed with time passing after operation in groups A and B; new tendon sheath was more maturer and smoother in group A than in group B. The degree of tendon adhesions in group A was significantly less than that in group B (P lt; 0.05) at 1 and 6 weeks after operation. The biomechanical test results showed there was no significant difference in the tendon slip length between 2 groups at 1 and 2 weeks after operation (P gt; 0.05), but the tendon slip length of group A was significantly longer than that of group B at 4 and 6 weeks after operation (P lt; 0.05). The total flexion angle of group A was significantly smaller than that of group B at 1, 2, 4, and 6 weeks after operation (P lt; 0.05). Conclusion It is effective in the prevention of tendon adhesion to use the amniotic membrane for repairing the tendon sheath defect, which is beneficial to recovery of the tendon sliding function.

    Release date:2016-08-31 04:07 Export PDF Favorites Scan
  • EFFECT OF TRIPTOLIDE ON ALLOGENIC TENDON TRANSPLANTATION IN REPAIRING TENDON DEFECT IN CHICKEN

    Objective Tri ptol ide can suppress immunological rejection reaction. To investigate the effect of tri ptol ide on allogenic tendon transplantation in repairing tendon defect in chicken. Methods The defect model of the third toes tendon was establ ished in 64 healthy-cleaning male Leghorn chickens (4-month-old, weighing 1.9-2.3 kg), which underwent allogenic tendon transplantation for repairing and were divided into 2 groups randomly (n=32). Tri ptol ide feeding[100 μg/(kg·d)] was given for 3 weeks in the experimental group and normal feeding in the control group. General condition of the chickens was observed after operation. The transplanted tendons were harvested from 4 chickens in each group for gross observation at 1, 2, 3, and 4 weeks after operation; the histological observation was performed at 1 and 3 weeks, and transmission electron microscope observation at 2 and 4 weeks. The blood and tendon were harvested from another 8 chickens in each group for flow cytometry and biomechanical tests respectively at 3 and 6 weeks. Results All chickens survived to the experiment end. Gross observation: with time extending, hyperemia and edema around transplanted tendon were rel ieved. Rarefaction adhering zone was seen in experimental group, and pyknotic adhering zone in control group. Histological observation: inflammatory reaction in experimental group was sl ighter than that in control group at 1 and 3 weeks. Transmission electron microscope observation: at 2 and 4 weeks, fibroblasts had big cell nucleus, more euchromatin, and l ittle heterochromatin in experimental group; however, there were small amount of rough endocytoplasmic reticulums with gentle expanded capsular space in control group, which contained sparse content. Flow cytometry test: at 3 and 6 weeks, peri pheral blood contained less CD4+ and CD8+ T lymphocytes in experimental group than in control group, and the ratio of CD4+ to CD8+ T lymphocyte significantly decreased in experimental group when compared with control group (P lt; 0.05). Biomechanical examination: at 3and 6 weeks, the maximum tensile strength in experimental group was bigger than that in control group, and tensile adhesion power in experimental group was smaller than that in control group. There were significant differences in the indexes between 2 groups (P lt; 0.05). Conclusion Tri ptol ide can suppress immunological rejection reaction, strengthen tendon healing strength, and reduce tendon adhesion in allogenic tendon transplantation.

    Release date:2016-08-31 04:23 Export PDF Favorites Scan
  • 微型钢板治疗掌指骨骨折的疗效分析

    目的 回顾性分析微型钢板治疗掌、指骨骨折的效果,评价其临床应用价值。 方法 2003 年1 月-2007 年6 月,采用微型钢板治疗掌、指骨骨折134 例174 处。男101 例,女33 例;年龄15 ~ 48 岁,平均27.8 岁。掌骨骨折105 处,指骨骨折69 处。闭合性骨折71 处,开放性骨折103 处。其中粉碎性骨折68 处,斜形或螺旋形骨折46 处,横形骨折32 处,粉碎性骨折合并骨质缺损13 处,病理性骨折(内生软骨瘤)合并骨质缺损15 处。合并伸屈肌腱损伤或神经损伤18 处,皮肤缺损11 处,累及关节的骨折16 处。伤后至手术时间2 ~ 72 h,平均6 h。 结果 术后伤口除1 例感染外,均Ⅰ期愈合。皮瓣供区Ⅰ期愈合。患者均获随访,随访时间6 ~ 12 个月,平均8.2 个月。X 线片示骨折线于术后6 ~ 11周消失。伤指外观无明显成角及旋转畸形。术后因疼痛不愿活动致关节僵硬3 指,累及关节的骨折致创伤性关节炎1 指,延迟愈合2 指,伤口感染1 指。无骨不连及畸形愈合。按照TAM 系统评定法,优115 处,良39 处,可12 处,差8 处,优良率88.5%。 结论 微型钢板治疗掌指骨骨折是一种有效的内固定方法

    Release date:2016-09-01 09:05 Export PDF Favorites Scan
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