【摘要】 目的 探讨顽固性癫痫外科术前与术中癫痫病灶定位的异同及手术方式的选择。 方法 2002年7月-2009年10月收治复杂、部分发作的顽固性癫痫78例。术前癫痫病灶定位主要采用头MRI及24 h视频脑电图检查，癫痫病灶局限于颞叶31例，颞叶、额叶47例。术中行24导皮层脑电图监测进一步定位癫痫病灶，并在其指导下联合多种癫痫术式完成手术。 结果 术前视频脑电图检查定位癫痫病灶与术中皮层脑电图监测定位具有高度一致性，但后者定位范围较前者有扩大。 结论 术中皮层脑电图监测证实并进一步精确定位癫痫病灶范围，以及在指导手术切除癫痫病灶范围，癫痫术式选择方面具有重要意义。【Abstract】 Objective To evaluate the preoperative and intraoperative epileptogenic focus location variation, and indication of surgical options for elevating outcome of refractory epilepsy patitents. Methods All of 78 refractory epilepsy patitents were complex partial seizure. Magnetic resonance imaging and 24 hour video electroencephalogram (VEEG) were used to orientate epileptogenic focus preoperatively. Thirty-one patiens were limited to temporal and forty-seven patients were both temporal and frontal. Twenty-four lead electrocorticogram (ECoG) was used to orientate epileptogenic focus intraoperatively and directed multiple operative patterns. Results Thereisa certain coherence between Preoperative VEEG and intraoperative ECoG epileptogenic focus location, but larger rangein latter. Conclusion Intraoperative e ECoG may orientate epileptogenic focus further accurately, for the suitable surgical options and appropriate surgical excision.
This paper presents a feature extraction method based on multivariate empirical mode decomposition (MEMD) combining with the power spectrum feature, and the method aims at the non-stationary electroencephalogram (EEG) or magnetoencephalogram (MEG) signal in brain-computer interface (BCI) system. Firstly, we utilized MEMD algorithm to decompose multichannel brain signals into a series of multiple intrinsic mode function (IMF), which was proximate stationary and with multi-scale. Then we extracted and reduced the power characteristic from each IMF to a lower dimensions using principal component analysis (PCA). Finally, we classified the motor imagery tasks by linear discriminant analysis classifier. The experimental verification showed that the correct recognition rates of the two-class and four-class tasks of the BCI competitionⅢand competitionⅣreached 92.0% and 46.2%, respectively, which were superior to the winner of the BCI competition. The experimental proved that the proposed method was reasonably effective and stable and it would provide a new way for feature extraction.
ObjectiveTo explore the clinical characteristics and surgical effect of low-grade glioma (LGG) secondary epilepsy.Methods45 cases of low-grade glioma secondary epilepsy were retrospectively studied during December 2010 and December 2020.There were 27 males and 18 females in this group. Their ages ranged from 10 to 69 years [mean (42.8±15.61) years]. And the illness duration ranged from 3 months to 5 years [mean (12.5±4.12) months]. The initial manifestation of all LGG was seizure attack.All the patients underwent CT and MRI examination before the operation. The LGG was located in the frontal lobe in 17 cases, temporal lobe in 8 cases, parietal lobe in 4 cases, frontal-temporal lobe in 7 cases, frontal-parietal lobe in 5 cases. Meanwhile the LGG was located in the left side in 31 cases, right side in 14 cases. The long-term video-EEG monitoring showed the epileptogenic lesion was located in the ispilateral frontal lobe in 20 cases, temporal lobe in 8 cases, frontal-temporal lobe in 12 cases, frontal-parietal lobe in 5 cases.All the patients were performed operation under the intra-operative electrocorticography (ECoG) monitoring.If necessary, enlarged epileptogenic cortical resection, cortical coagulation or MST was added.After the operation, all the patients were followed-up for half a year to 10 years [mean (4.7±1.83) years] to observe the surgical effect.Results42 cases of LGG underwent gross total resection and 3 subtotal resection intra-operatively. Anterial temporal lobectomy (ALT) was added in 19 cases whose LGG were invovled with temporal lobe.13 cases were added cortical cogulation and 5 cases MST.The post-operative pathology showed astrocytoma grade Ⅰin 20 cases, astrocytoma grade Ⅱ in 12 cases, oligodendroglioma in 11 cases and dysembryoplastic neuroepithelial tumor (DNET) in 2 cases. The post-operative follow-up showed that 30 cases lived well, 12 cases recurred and received re-operation, 3 cases died. Meanwhile, 42 cases were seizure free and 3 cases had occasional seizure attack during the follow-up.ConclusionsTo the patients with LGG secondary epilepsy, if pre-operative long-term EEG monitoring is in accordance with imaging examination, early LGG resection combined with epileptogenic lesion resection should be performed under the guidance of ECoG monitoring.And the post-operative effect is satisfactory.