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find Author "石宇" 3 results
  • Efficacy and safety of iguratimod versus methotrexate in the treatment of rheumatoid arthritis: a meta-analysis

    ObjectivesTo systematically review the efficacy and safety of iguratimod compared with methotrexate in the treatment of rheumatoid arthritis.MethodsPubMed, EMbase, The Cochrane Library, VIP, CBM, WanFang Data and CNKI databases were electronically searched to collect randomized controlled trials (RCTs) of the efficacy and safety of iguratimod compared with methotrexate in the treatment of rheumatoid arthritis from inception to June 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 10 RCTs involving 970 patients were included. The results of meta-analysis showed that: there was no statistical difference between iguratimod and methotrexate in ACR20 (RR=1.06, 95%CI 0.91 to 1.23, P=0.49), ACR50 (RR=0.93, 95%CI 0.73 to 1.19, P=0.55), ACR70 (RR=0.92, 95%CI 0.62 to 1.39, P=0.70), morning stiffness time (MD=0.45, 95%CI –0.26 to 1.16, P=0.22), tender joint count (MD=0.07, 95%CI –2.31 to 2.45, P=0.95), swollen joint count (MD=–0.30, 95%CI –1.44 to 0.84, P=0.61), health assessment questionnaire (MD=0.01, 95%CI –0.05 to 0.07, P=0.73) and the rate of adverse effects (RR=0.66, 95%CI 0.41 to 1.07, P=0.09). Meta-analysis of 2 RCTs using double-blind method showed that, iguratimod was superior to methotrexat in the patient (MD=4.11, 95%CI 0.11 to 8.10, P=0.04) and physician (MD=4.81, 95%CI 0.93 to 8.69, P=0.01) global assessment of disease activities.ConclusionsCurrent evidence shows that the efficacy and safety of iguratimod in the treatment of rheumatoid arthritis are similar to methotrexate. And iguratimod is superior in global assessment of disease activities by patients and doctors. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

    Release date:2019-06-24 09:18 Export PDF Favorites Scan
  • 尺桡骨双折合并早期骨筋膜室综合征的手术治疗

    目的总结尺桡骨双折合并早期骨筋膜室综合征的治疗方法及疗效。 方法2009年6月-2014年4月,采用切开复位内固定、封闭式负压引流(vaccum sealing drainage,VSD)覆盖创面、二期植皮治疗尺桡骨双折合并早期骨筋膜室综合征16例。其中男10例,女6例;年龄18~51岁,平均32岁。致伤原因:摔伤7例,高处坠落伤5例,交通事故伤4例。受伤至手术时间2~8 h,平均4 h。术后1年采用Anderson评价系统评价疗效。 结果术后患者切口均Ⅰ期愈合,无感染、植皮坏死等并发症发生。16例均获随访,随访时间12~30个月,平均24个月。患肢无肌肉挛缩现象,手指血运、感觉正常。随访期间无内固定物断裂,无骨不连发生。尺桡骨骨折均愈合,愈合时间3~9个月,平均5个月。术后1年患侧肘关节、腕关节及前臂功能恢复良好。按Anderson评价系统评价疗效,获优12例,良4例。 结论尺桡骨双折合并早期骨筋膜室综合征行切开复位内固定、VSD覆盖创面、二期植皮治疗,手术操作简便,利于早期功能锻炼,疗效满意。

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  • 近指间关节复合组织缺损的显微外科修复

    目的总结近指间关节复合组织缺损显微外科修复的疗效。 方法2005年3月-2011年3月,对12例示、中指近指间关节复合组织缺损患者采用游离带关节的第2足趾复合组织移植修复。男9例,女3例;年龄17~38岁,平均24.6岁。致伤原因:电锯伤3例,交通事故伤4例,机器绞伤5例。软组织缺损范围3.0 cm × 1.0 cm~5.5 cm × 2.5 cm。伤后至手术时间3 h~4 d,平均32 h。 结果12例均获随访,随访时间5个月~4年,平均2.5年。术后48 h 1例发生皮瓣静脉危象,行静脉皮瓣移植修复成活;余11例移植复合组织均顺利成活。移植骨均愈合良好,愈合时间5~12个月,平均8个月。随访期间无关节退行性变。11例术后14个月按照中华医学会手外科学会上肢部分功能评定试用标准评价,获优3例,良4例,可4例。 结论对于近指间关节复合组织缺损,通过显微外科方法修复可以最大程度恢复手指外观、感觉及功能。

    Release date:2016-08-31 04:22 Export PDF Favorites Scan
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