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find Author "石紫燕" 2 results
  • 基于雨课堂的翻转课堂模式在长程脑电图教学实践中的探索

    长程脑电图(Long-term electroencephalogram,LT-EEG)教学是神经专科教学的重要组成部分,其专业性强,理论抽象,图形复杂,学生学习难度大,传统的教学模式难以理解和掌握。翻转课堂作为一种新型的教学模式,能够有效提高学生的学习主动性和参与度。雨课堂作为一款智慧教学平台已被各大高校应用于多种教学领域。本文探讨了基于雨课堂平台的翻转课堂模式在 LT-EEG教学的应用实践。通过详细描述教学设计、实施过程及效果评估,本文旨在探索如何利用雨课堂平台以及优化长程脑电图的教学效果,提升学生的学习效果和实践能力,激发学员学习兴趣,提高脑电图教学质量,促进学科的应用和发展,为神经专科和相关专业培养合格医疗人才奠定坚实的基础。

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  • Myasthenia gravis with both acetylcholine receptor antibody and muscle-specific tyrosine kinase antibody positivity: clinical analysis of 13 cases

    ObjectiveTo explore the clinical features of myasthenia gravis (MG) harboring both acetylcholine receptor antibody (AChRAb) and muscle-specific tyrosine kinase antibody (MuSKAb) positivity.MethodsWe searched PubMed, Web of Science, Embase and China National Knowledge Infrastructure databases (from inception to November 2016), to collect the case reports of MG with both AChRAb and MuSKAb positivity. Along with one case discovered in Department of Neurology, West China Hospital, the clinical data of the cases were retrospectively analyzed.ResultsA total of 13 double-seropositive MG patients were enrolled in this study, demonstrating a marked female predominance (including 1 male and 12 females) and a younger age at onset [(31.07±24.77) years]. During the disease course, 10 of the included patients presented severe bulbar involvement, dyspnea and neck weakness, with myasthenic crisis in 6 individuals. Among the 11 patients with detailed records, abnormal thymus glands comprised 4 thymus hyperplasia and one thymoma. While the response to oral pyridostigmine was unsatisfactory in 11 double-seropositive MG patients, ranging from mild benefit to overt intolerance; the patients treated with plasma exchange (3/3), rituximab (1/1) or corticosteroid (7/12) improved dramatically, with other immumosuppressants and intravenous immunoglobulin partially responsive. Moreover, 5 patients undergoing thymectomy improved markedly or partially.ConclusionsCompared with MG patients with MuSKAb positivity merely, the condition of the double-seropositive MG patients seem to be more severe and further inclined to myasthenic crisis. The incidence of abnormal thymus, such as thymus hyperplasia, is higher. Thymectomy may be an effective treatment for such patients.

    Release date:2018-06-26 08:57 Export PDF Favorites Scan
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